DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myo31DF

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	1131	Identity:	245/1131 - (21%)
Similarity:	429/1131 - (37%)	Gaps:	241/1131 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMP 627
            |:|...|..::....:..||:|:.:..|:|..|...:.:||...:::|..:.:..::|.:..:..
  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73

  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAY-NNFINAEKVNALC 691
            ||::::|.:|||.|.:.::|..::..|.||:||:.:.|..:.|:|....|. .|.|...| |.|.
  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVK-NVLI 137

  Fly   692 ---TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIM 753
               .|||.|||.||..|.|::|..:.:.::||.........:...|.|:.|..::...|.:||..
  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202

  Fly   754 TRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGI 818
            .:||.||.....::..|:..|.:    :..|:|...|.....:|:..|..||:||......|:.|
  Fly   203 YQLLRGANDNELRQYELQKETGK----YHYLNQGSMDILTEKSDYKGTCNAFKTLGFSTDEVQTI 263

  Fly   819 WSILAAIYHLGIAGVTKLGTGSTARTQF---------ANPTAARKASGLLGVNLEDLSSAAFGLT 874
            |..:||:.|||             ..:|         :|....:..:.||.|...:||:|   ||
  Fly   264 WRTIAAVLHLG-------------NVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTA---LT 312

  Fly   875 QPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQIC-----TSSHTIAS 934
            :.....||....|...: |..|:.   .:||...:|......:::.|||.|.     |.:...:.
  Fly   313 KRVIAAGGNVMQKDHNA-TQAEYG---KDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSV 373

  Fly   935 IMLIDTPGFQNPASCGQQVGATLADLRH------NYLQERLQMLFHHTTLVAPRDRYAQELVE-- 991
            |.::|..||:            :.|...      ||..|:||.||....|...::.|.:|.:|
  Fly   374 IGVLDIYGFE------------IFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWT 426

  Fly   992 -IEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNS-NDDTFLER 1054
             ||..                  .|.::    .||.|...:|::.::||..:.... .|||.|..
  Fly   427 NIEYF------------------NNKII----CDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGA 469

  Fly  1055 L------FSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQ 1113
            :      ..||..|:.....::......|.:.|..|  .|:|.::|::.        :|..:|.|
  Fly   470 MDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAG--DVIYNINGFIE--------KNKDTLYQ 524

  Fly  1114 DSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTV 1178
            |     ..||...|.......|       ..||.|.:::.:  :|..|...:.:.|:.
  Fly   525 D-----FKRLLHNSKDANLSEM-------WPEGAQDIKKTT--KRPLTAGTLFQRSMA------- 568

  Fly  1179 DGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVL 1243
             .::.||.:....:|.|.                .|:........:||.|     ..|:|...:|
  Fly   569 -DLVVTLLKKEPFYVRCI----------------KPNDLKSSTVFDEERV-----EHQVRYLGLL 611

  Fly  1244 EAARLHRLGFPESVPLLEFVRRFGLLA----GDLASNKDVSVEQILAVNELDVASYRIGPSQILF 1304
            |..|:.|.||.......:|:.|:.:::    .:..:..|....::|...:......:.|.::|..
  Fly   612 ENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDVKYGHTKIFI 676

  Fly  1305 RS-GVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPW 1368
            || ..|..||.:|:.::...:..||...||::.|:...:.:.             |...||.:..
  Fly   677 RSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKA-------------AITIVRAYKA 728

  Fly  1369 WRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEE 1433
            ::|...|..|.|..|..:|::...:.:...:..|            ..:|:||||..: .|....
  Fly   729 YKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPL------------AGRKVEAKLHRM-FDFWRA 780

  Fly  1434 RSTAH--------------IATERLEAETAERLKLEKELGD-----QTN--------KVKNLQ-- 1469
            ....|              ||...|........:..:.:||     |.|        .:||::
  Fly   781 NMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNH 845

  Fly  1470 ----ETTEKLEMELICAK-------SDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRR 1523
                ||.:::.......|       ::...|..|......||:     |.|::.:.|.::.  |.
  Fly   846 PADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGI-----KNKFKDMKRTIKI--RE 903

  Fly  1524 LHT-QHEHDLEQLVAL----KKHLEMKLSDAYEEVVEQR--QVVGQWKRKAQKMTNEMNDLRMLL 1581
            |.: ......:||:..    .|.|...|...|..:.|.|  :|||...:|...:|.  .:||:
  Fly   904 LTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRIGEVVGIVCKKYHDLTG--TELRV-- 964

  Fly  1582 EEQNARNNL---LEKKQRKFDAECQS 1604
               |...|:   |:.|.|....|..|
  Fly   965 ---NVTTNISCRLDGKARIITVEAAS 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	179/792 (23%)
		MYSc_Myo18	575..1305	CDD:276837	171/767 (22%)
		GBP_C	<1540..1750	CDD:303769	20/70 (29%)
		COG1340	1565..1833	CDD:224259	11/43 (26%)
		coiled coil	1723..1734	CDD:293879
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	179/792 (23%)
		MYSc_Myo1	21..677	CDD:276829	171/767 (22%)
		Myosin_TH1	801..983	CDD:283635	40/195 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930