DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and AgaP_AGAP008221

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_555244.3	Gene:	AgaP_AGAP008221 / 3291681	VectorBaseID:	AGAP008221	Length:	1719	Species:	Anopheles gambiae

Alignment Length:	522	Identity:	105/522 - (20%)
Similarity:	171/522 - (32%)	Gaps:	176/522 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ADANGGSNGGA-------VGAADPEQDRGNEEIVASVMTHIESRASNGAGVSVNYSEVTHSLLSG 148
            |..|||.|||.       ..|.|..|:.|   |..:|:..:::..:|     .|:.   |.||
Mosquito   186 AQTNGGLNGGGRKLTKSLSEAGDRLQENG---IDPNVLQPVDTGTAN-----ANFD---HELL-- 237

  Fly   149 GLKNRFLPPIPPK-------PPKRGI-----LKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLRN 201
               :|.....|||       ||...:     |..||::....|.:           ||.....||
Mosquito   238 ---HRTQSEEPPKSPFTITSPPATHVGPHFELPSSRTSSQLSHSD-----------GTHLTHSRN 288

  Fly   202 TFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDGEQTGGQQRAMTLPANARYGALPQ--- 263
                                :|....||:.|     :||.:|..:      .|:..|.|||:
Mosquito   289 --------------------HSQDSATSYRS-----TDGSRTSYE------TASYPYDALPRRTC 322

  Fly   264 --GNSQGSHLHVL-------------------TSPSPSADSLTDTTNSSFATPPFSLSPVGESQG 307
              ...:..|.|.|                   :.|:..|......:|.|......|...:..:..
Mosquito   323 IHHKPEEFHTHTLPRRDHGHAHHHHDIVYRDQSHPALPAPEHLILSNGSVNQDVRSFDSMPTATA 387

  Fly   308 IDRWARVHAFEDVELPLPPVQLVKLPPPRQLV-IRRQKSPRQDFGFSLRKAICLDRTESLTSPIF 371
            ::|....||   :..|..|  |||..||.... ...|.:|..          |     .:|.|..
Mosquito   388 LNRRMSAHA---ITQPFQP--LVKPQPPTLTSHYTSQTAPPS----------C-----PVTPPNI 432

  Fly   372 RPVIFAE--PGAGGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVEL 434
            :|:...:  ..:..|:......|...:::|.| || .|||.|:.        ...|.||.
Mosquito   433 QPLDMQDDTKSSSEGSCSTCDSDSEQELDGMP-GE-EREIFIDF--------KPRVSPVP----- 482

  Fly   435 SKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNG-------GGEEGGAKGVGH 492
                 :|.....:::..:.:.|.   |..:.::|  :.|...:|:|       |.::.|...:..
Mosquito   483 -----SPGAVKKKKLQKAQSEGE---LMHADARR--KASVTADGDGGSSTVPTGSDDEGRSTMRE 537

  Fly   493 DLEA---------DVADASQPE---RVWLVHRGGF---TAAIRLPTASSGRDEENKLSLRLLHNG 542
            ...|         |.:::|.|:   :|....:..|   :.::..||:....|||.:     .|||
Mosquito   538 QCAAPKLPKPDYRDASESSVPDDEPQVKDRRKESFRKRSVSLDQPTSCEQEDEEER-----EHNG 597

  Fly   543 EQ 544
            .|
Mosquito   598 TQ 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	16/89 (18%)
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
AgaP_AGAP008221	XP_555244.3	NESP55	<387..583	CDD:115071	44/240 (18%)
		PDZ_signaling	1421..1496	CDD:238492
		PH-like	1507..1609	CDD:302622
		PH	1514..1608	CDD:278594
		PH-like	1633..1719	CDD:302622
		PH	1635..1719	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900