DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and gopc

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_956851.1	Gene:	gopc / 326887	ZFINID:	ZDB-GENE-030131-5086	Length:	455	Species:	Danio rerio

Alignment Length:	487	Identity:	103/487 - (21%)
Similarity:	174/487 - (35%)	Gaps:	135/487 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1482 AKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQ---HEHDLEQL-VALKKHL 1542
            |.|..:|:|....|    ..|.|:...::..|. |.||.|..:...   .|.|.:|. :..:...
Zfish     8 AGSPGSGLSAGPAA----ATGSGMSMFRWLEVL-EKEFDKAFVDVDLLLGEIDPDQADITYEGRQ 67

  Fly  1543 EM-KLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQ 1606
            :| .||..:.::..:.|.:.|...|.:.   ::.|||..|.:..|...::||:..:     |.||
Zfish    68 KMTSLSSCFAQLCHKAQTIFQLNHKLEA---QLVDLRSELTDVQAEKVVVEKEVHE-----QLLQ 124

  Fly  1607 -DAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFGGGTEEE 1670
             .|::.:.|||.....:.|.::            .|:.:...|||...|:...:|.......|.|
Zfish   125 LHAMQLKLQAKGGQAVDSDSIK------------DRMPVPSVEEKEKELEASKKEKVKEVKLEAE 177

  Fly  1671 FAQLRRSKNETERR---------------AKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEA 1720
            ...|:: :||..||               ||..::||.....|||||.:
Zfish   178 VKMLKK-ENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGR---------------- 225

  Fly  1721 RRESQQRDEELEEVRGNGYKKIKALECQLETE---HEERTLL--LREKHELERRLSSMEDRDRVD 1780
                        :::|..:.|   |..|||.|   |..:|::  .|.:::.::.|.|     .|.
Zfish   226 ------------DMKGPAHDK---LWNQLEAEIHLHRHKTVIRACRGRNDPKKPLPS-----PVG 270

  Fly  1781 RDAEEALNQKLRRDLRKYKALLKDAQ-----------------------TQ-LERLKADTPGKTL 1821
            .|.:.....:....:||.....:|.:                       || .||......|..:
Zfish   271 HDTDSLKKTQGVGPIRKVVLTKEDHEGLGISITGGKEHGVPILISEIHPTQPAERCGGLHVGDAI 335

  Fly  1822 IRQLRNQLEDAESARSLAMKARQTAEAEL-------------TEVQAMFDESHRAR---NDAEER 1870
            :......|.||:...::.:.::|..|.|.             ..|:...|..||.|   ::.||.
Zfish   336 LAVNNINLRDAKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDDSGHRYRLYLDELEEA 400

  Fly  1871 ANAAHR----DRAELQA---QIEENEEELGEL 1895
            :.|.|.    |.|.|||   .:..|..|.|::
Zfish   401 SAANHNNGTADPASLQAVGKHLVNNRTENGDV 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	47/226 (21%)
		COG1340	1565..1833	CDD:224259	62/312 (20%)
		coiled coil	1723..1734	CDD:293879	0/10 (0%)
gopc	NP_956851.1	PDZ_signaling	285..367	CDD:238492	14/81 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900