DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Gopc

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001101101.2	Gene:	Gopc / 309774	RGDID:	1309512	Length:	463	Species:	Rattus norvegicus

Alignment Length:	416	Identity:	89/416 - (21%)
Similarity:	169/416 - (40%)	Gaps:	88/416 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1402 LEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAE-----------TAERLKLE 1455
            |.:|:.|::::..|.::....||.....|..:..|......:|||:           .||::.||
  Rat    53 LGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLRSELTETQAEKVVLE 117

  Fly  1456 KELGDQTNKVKNLQ-----ETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVAR 1515
            ||:.||..::.:.|     :|.:.::...|.||..::.: ||.:.|.|   .....|:|..|:..
  Rat   118 KEVHDQLLQLHSTQLQLHAKTGQSVDSGAIKAKLSVHSM-EDLERELE---ANKTEKVKEARLEA 178

  Fly  1516 ELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAY----------EEV---VEQRQVVGQWKRKA 1567
            |::..::      |::     ||::|:.:..::.|          :|:   |:|.|::|
  Rat   179 EVKLLRK------ENE-----ALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLG------ 226

  Fly  1568 QKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFT 1632
            :.|....:|  .|..:..|..:|  .:.:.....|:..|| :::..||..  |.::|.|:.
  Rat   227 RDMKGPAHD--KLWNQLEAEIHL--HRHKTVIRACRGRQD-LKRPMQAPP--GHDQDSLKK---- 280

  Fly  1633 LEQTLADTRLDLEFKEE-----------KLASLQRELEEMTFG------GGTEEEFAQLR-RSKN 1679
             .|.:...|..|..||:           |...:...:.|:..|      ||.....|.|. ...|
  Rat   281 -SQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAVLAVNGVN 344

  Fly  1680 ETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDE-ELEEVRGNGYK--- 1740
            ..:.:.||....|.:..|:|: .|...:..|:..:....|...||..|.. .|:|:.|.|..
  Rat   345 LRDTKHKEAVTILSQQRGEIE-FEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNSGAS 408

  Fly  1741 -KIKALECQLETEHEERTLLLREKHE 1765
             |..:.|.::...:.::|  :|:.||
  Rat   409 CKDSSGEMKVLQGYNKKT--VRDAHE 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	50/245 (20%)
		COG1340	1565..1833	CDD:224259	47/224 (21%)
		coiled coil	1723..1734	CDD:293879	4/11 (36%)
Gopc	NP_001101101.2	SMC_prok_B	<35..>215	CDD:274008	37/176 (21%)
Gopc	NP_001101101.2	PDZ_signaling	287..369	CDD:238492	18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900