DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Ush1c

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_006229284.1	Gene:	Ush1c / 308596	RGDID:	1303329	Length:	910	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	106/512 - (20%)
Similarity:	189/512 - (36%)	Gaps:	162/512 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1238 RGSQVLEAARLHRLGFPESVPLLEFVR---RFG-------LLAGDLASNKDVSV-EQILAVNELD 1291
            |.|:.|:..||.|| .||.:.|  .||   .||       |:.|..|.:..:.| ::|:.:|...
  Rat    80 RRSRKLKEVRLDRL-HPEGLGL--SVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYS 141

  Fly  1292 VASYRIGPSQILFRSGVLSELEAKRDVLLS----------------------DRIIQLQAFCRGY 1334
            ::|        .....|::.:..|:.|.:.                      |:.:......||.
  Rat   142 ISS--------CTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPEEPLKWQYVDQFVSESGGVRGG 198

  Fly  1335 LA--------RKKMSQRRVQELAVRC------IQR------NVKAFLAVRDWPWWRLLVRVTPLL 1379
            |:        .||:....|....:.|      ||:      |||.
  Rat   199 LSSPGNRTTKEKKVFISLVGSRGLGCSISSGPIQKPGIFVSNVKP-------------------- 243

  Fly  1380 NVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERL 1444
            .....|..|:|.::.:     ::..|:....:.|.....|::..| ||:.:..........|:|.
  Rat   244 GSLSAEVGLETGDQIV-----EVNGIDFTNLDHKEAVNVLKSSRS-LTISIVAGAGRELFMTDRE 302

  Fly  1445 EAETA-------ERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVG 1502
            ..|.|       :.|.::|.|..::||:...|:..|:...:.|..|:         ..|||.
  Rat   303 RLEEARQHELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKA---------AEENER--- 355

  Fly  1503 GGVYKLKYERVARELEFTKRRLHTQHEHD---LEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWK 1564
               |:.:.|:::.|.|..|:    |.|.|   .|||: |.|.:   .::.:...:.:.:..|.:.
  Rat   356 ---YRKEMEQISEEEEKFKK----QWEEDWGSKEQLI-LPKTI---TAEVHPVPLRKPKSFGWFY 409

  Fly  1565 RKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQ---AKERYGREKDVL 1626
            |...|.             ...|....|||:.|:|    ||||..:.:::   .::.|..::::|
  Rat   410 RYDGKF-------------PTIRKKAKEKKKAKYD----SLQDLRKNKKELEFEQKLYKEKEEML 457

  Fly  1627 QAEK----FTLEQTLADT-RLDLEFKE--------------EKLASLQRELEEMTFG 1664
            :.||    ..|.|.:::| |.|||..|              ::::|.:.|:.|||.|
  Rat   458 EKEKQLKINRLAQEVSETEREDLEESEKTQYWVERLCQTRLQQISSAENEITEMTTG 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	23/89 (26%)
		MYSc_Myo18	575..1305	CDD:276837	21/77 (27%)
		GBP_C	<1540..1750	CDD:303769	32/147 (22%)
		COG1340	1565..1833	CDD:224259	30/122 (25%)
		coiled coil	1723..1734	CDD:293879
Ush1c	XP_006229284.1	harmonin_N	2..80	CDD:259819	106/512 (21%)
		PDZ_signaling	85..165	CDD:238492	22/90 (24%)
		PDZ_signaling	209..289	CDD:238492	18/105 (17%)
		Cgr1	<316..>358	CDD:281823	13/56 (23%)
		PDZ_signaling	751..838	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900