DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and PDZD2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_005248326.1 Gene:PDZD2 / 23037 HGNCID:18486 Length:2873 Species:Homo sapiens


Alignment Length:2336 Identity:416/2336 - (17%)
Similarity:720/2336 - (30%) Gaps:829/2336 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   172 RSNMTNVHEEISFAGSAGGA---------GGTPEMLLRNTFQNE--SLYEGAARGAGSIGSNSSQ 225
            |..:.:::.::.......||         ||...:::...|:::  |.|.|.:       ||||:
Human   139 RDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFKHKAHSTYNGNS-------SNSSE 196

  Fly   226 HGTSFTSVESLRSDGEQTGGQQRAMTL----PANARYGALPQGNSQGSHLHVLTSPSPSADSLTD 286
            .|.  |....|.....:.|.:.|...:    |||    ..|:.:...:...|.:.||...::..|
Human   197 PGE--TPTLELGDRTAKKGKRTRKFGVISRPPAN----KAPEESKGSAGCEVSSDPSTELENGPD 255

  Fly   287 TTNSS-----FATPPFSLSPVG----ESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRR 342
            ....:     ....|.||..|.    |...:||... |.....:.||......:         |.
Human   256 PELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTE-HRIPKTDAPLTTSNDKR---------RF 310

  Fly   343 QKSPRQDFGFSLRKAICLDRTE-------------------------SLTSPIFRPVIFAEPGAG 382
            .|..:.||    :.:.||.|.|                         |..||  ..::..:...|
Human   311 SKGGKTDF----QSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSP--HAIVVTQVKEG 369

  Fly   383 GGA--TGLLP-GDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEV----QPVAELVELSKRCMA 440
            |.|  .|.|. ||.|:.:||..:..|..|..:.::|::...|.:.|    ....:|:.|:.:.:.
Human   370 GAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLP 434

  Fly   441 PSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGV-----GHDLEADVAD 500
            ..|::||::.....|                  ..:..:|..:||.:..|     |.|...||..
Human   435 DLTSSVEDVSSWTDN------------------EDQEADGEEDEGTSSSVQRAMPGTDEPQDVCG 481

  Fly   501 ASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVED 565
            |.:       .:|..         .|.:...||:.|:...:|        .|.:     |:.||:
Human   482 AEE-------SKGNL---------ESPKQGSNKIKLKSRLSG--------GVHR-----LESVEE 517

  Fly   566 ICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHV 630
            ..||...|.                                                    .|.:
Human   518 YNELMVRNG----------------------------------------------------DPRI 530

  Fly   631 YSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILE 695
                     .::|..||      ||         ||:|..|..::.|...:...:|         
Human   531 ---------RMLEVSRD------GR---------KHSLPQLLDSSSASQEYHIVKK--------- 562

  Fly   696 AFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIM--TRLLA 758
                        :||  .|.:...:...::...|:..::...:..|:.||    |.|.  ...:.
Human   563 ------------STR--SLSTTQVESPWRLIRPSVISIIGLYKEKGKGLG----FSIAGGRDCIR 609

  Fly   759 GAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILA 823
            |..|:..|.:......:||.                     |..:..|.|:::...::|:     
Human   610 GQMGIFVKTIFPNGSAAEDG---------------------RLKEGDEILDVNGIPIKGL----- 648

  Fly   824 AIYHLGIAGVTKLGTG---STARTQFANPT---------AARKAS-------GLLGVNLEDLSSA 869
             .:...|....::.:|   .|.||:..:|:         .:|.||       |......::.||:
Human   649 -TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSS 712

  Fly   870 AFGLTQPNAPNG---GLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHT 931
            :.|...|...:.   .::.:|.|....|.......||....|:|..:||                
Human   713 SLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLA---------------- 761

  Fly   932 IASIMLIDTPG----FQNPASCGQQV-GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVE 991
                     ||    .::..|.|.|: .....::||..|.:      .|..|             
Human   762 ---------PGSVAKMESNLSRGDQILEVNSVNVRHAALSK------VHAIL------------- 798

  Fly   992 IEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSN--------- 1047
                  |:|.|||:..:|.:.|...|   |::::.|...|...    :|:...||:         
Human   799 ------SKCPPGPVRLVIGRHPNPKV---SEQEMDEVIARSTY----QESKEANSSPGLGTPLKS 850

  Fly  1048 ------DDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVL-YAVDGWVRHSREHPG- 1104
                  |....|...|                  |:..|.:.|  |:. :.|.|  ....:||| 
Human   851 PSLAKKDSLISESELS------------------QYFAHDVPG--PLSDFMVAG--SEDEDHPGS 893

  Fly  1105 ---------IRNAVSLLQDSSREEINRLYIGSLTRGSG---AMVFCGSFAGLEGT-QSLRRVSSI 1156
                     :..:.|..::..:...|.|......|.||   ..|.....|.|.|: |:|      
Human   894 GCSTSEEGSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQAL------ 952

  Fly  1157 RRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGS----PSSA 1217
                      ||.::.|.|                 |.|| ..::|....::...|.    |.:.
Human   953 ----------RNPLLRQRK-----------------VGCY-DANDASDEEEFDREGDCISLPGAL 989

  Fly  1218 AGQVS--SEEEMVNVPLLRSQLRGSQV---LEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNK 1277
            .|.:.  ||::...|.:  |..:|..|   .|..|...:....|.|||               ..
Human   990 PGPIRPLSEDDPRRVSI--SSSKGMDVHNQEERPRKTLVSKAISAPLL---------------GS 1037

  Fly  1278 DVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEA---------KRDVLLSDRIIQLQAFCRG 1333
            .|.:|:.:....:|.|||         .:.:....||         |:::..|....:|:     
Human  1038 SVDLEESIPEGMVDAASY---------AANLTDSAEAPKGSPGSWWKKELSGSSSAPKLE----- 1088

  Fly  1334 YLAR-----------KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQ 1387
            |..|           ....|::.:.|..|                 .|.:.||:|  :..|:|.:
Human  1089 YTVRTDTQSPTNTGSPSSPQQKSEGLGSR-----------------HRPVARVSP--HCKRSEAE 1134

  Fly  1388 LKTANEELLMLRAKLEKIECD-RSEVKAENQKL------------EAKLSELTVDLAEERSTAHI 1439
            .|.:..:.:.|..:... .|| .|.|:|.:.|:            :..|.:||...|...::..:
Human  1135 AKPSGSQTVNLTGRAND-PCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCEL 1198

  Fly  1440 AT--ERLEAE--TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENED- 1499
            |:  ..|:|.  |....|...|||.|              .|..:.:.|||......:.|.:.| 
Human  1199 ASALSHLDASHLTENLPKAASELGQQ--------------PMTELDSSSDLISSPGKKGAAHPDP 1249

  Fly  1500 ---GVGGG---------------VYKLKY---------------ERVARELEFTKRR--LHTQHE 1529
               .|..|               |.|.|.               |:.|...:::|.|  ..|...
Human  1250 SKTSVDTGQVSRPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTP 1314

  Fly  1530 HDLEQLVALKKHLEMKLSDAYEEVV--------------EQRQVVGQWKRKAQKMTNEMNDLRML 1580
            |:..::.||:     ......|.:.              ||||.......||.:||.      :.
Human  1315 HNTRRVAALR-----GAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTG------IH 1368

  Fly  1581 LEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYG-----------REKDVLQAEKFTLE 1634
            ..|.:...:|||..........|:....:......||..|           ||..|...:.|..|
Human  1369 APESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKE 1433

  Fly  1635 QTLADTRLDLEFKEEKLASLQRELEEMTFGGGTEEEFAQ-----------------LRRSKNETE 1682
                   ||        ||..|.....|...|::|..||                 :...:..:.
Human  1434 -------LD--------ASAARSPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSP 1483

  Fly  1683 RRA-KEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALE 1746
            ||| ........:.|.|..:|:........|:.                 :....|..:...:. 
Human  1484 RRAWAAGAPAYPQWASQPSVLDSINPDKHFTVN-----------------KNFLSNYSRNFSSF- 1530

  Fly  1747 CQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAE-EALNQKLR---RD----LRKYKALLK 1803
                  ||:.|.|.......|..||||.. |..|..:: |:|.:..|   ||    .|...:|.|
Human  1531 ------HEDSTSLSGLGDSTEPSLSSMYG-DAEDSSSDPESLTEAPRASARDGWSPPRSRVSLHK 1588

  Fly  1804 D--AQTQLERLK--------------ADTPGKTLIRQLRNQLEDAESARSLAMKARQTAE--AEL 1850
            :  ::::.|:::              |..|.:..|        ...||:.|::|.....|  |..
Human  1589 EDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAI--------CPASAKVLSLKYSTPRESVASP 1645

  Fly  1851 TEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSE 1915
            .|..|....|:.:..|:.:.::.     .|:.:|..|...:: ...:.:..:..:..||..:.|.
Human  1646 REKAACLPGSYTSGPDSSQPSSL-----LEMSSQEHETHADI-STSQNHRPSCAEETTEVTSASS 1704

  Fly  1916 AEFKLNEMEAERNNLKEQVAE-----------------LQHRLDNVENLG------DPSMAMMSK 1957
            |      ||   |:...:||.                 |:|.|.:.|.|.      :.:.::.|.
Human  1705 A------ME---NSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSF 1760

  Fly  1958 RLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKM--------------REMQA 2008
            .::: .|..||.||             |.|....:.|.:.:.:.||              :..|.
Human  1761 SVDV-PKNGESVLE-------------NLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQG 1811

  Fly  2009 QDVIKKSQKS-----LRDMREEFHAVSSREQESLT------------RRKDLEKK--VEQMESEG 2054
            ..:..|::|.     .|....:...|||.:::.:|            ..|||.||  .|.:.:.|
Human  1812 THLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNG 1876

  Fly  2055 AALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSV---GSISDLEDRLRPVHVKRSSQQSL 2116
            ...|...:|         :.:..:|:.:::....:.::|   |:     |..:|:...::|.::|
Human  1877 QKAKCGPKL---------KRLSLKGKAKVNSEAPAANAVKAGGT-----DHRKPLISPQTSHKTL 1927

  Fly  2117 NGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANKPDTKPAAS 2177
            :.::         |.|..|.:.:| ..|.|..:|.||   :..|.:|...|.....||:.|
Human  1928 SKAV---------SQRLHVADHED-PDRNTTAAPRSP---QCVLESKPPLATSGPLKPSVS 1975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 26/118 (22%)
MYSc 556..1317 CDD:214580 139/837 (17%)
MYSc_Myo18 575..1305 CDD:276837 130/797 (16%)
GBP_C <1540..1750 CDD:303769 40/252 (16%)
COG1340 1565..1833 CDD:224259 58/320 (18%)
coiled coil 1723..1734 CDD:293879 0/10 (0%)
PDZD2XP_005248326.1 PDZ_signaling 335..416 CDD:238492 17/82 (21%)
PDZ_signaling 589..670 CDD:238492 17/111 (15%)
PDZ_signaling 726..810 CDD:238492 24/133 (18%)
PDZ_signaling 2623..2694 CDD:238492
PDZ 2785..2867 CDD:214570
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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