DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myh11

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_006521906.1	Gene:	Myh11 / 17880	MGIID:	102643	Length:	1979	Species:	Mus musculus

Alignment Length:	1930	Identity:	517/1930 - (26%)
Similarity:	864/1930 - (44%)	Gaps:	374/1930 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 ADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDL 562
            ||....:.||: ..:.||.|      ||...::.:::.:.|:.||:::||.:||::|.|.|....
Mouse    28 ADWVAKKLVWVPSEKQGFEA------ASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSK 86

  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMP 627
            |||:.||..||||||||.||:||.|.||:|.:|...:||||...|.:||||:|.|::|.|..:||
Mouse    87 VEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKYLPIYSEKIVDMYKGKKRHEMP 151

  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYN-----------NF 681
            ||:|::|.|||||:::.|.|||::..|.||:||:.:.|..:.|||:.|.::.           :|
Mouse   152 PHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITQGPSF 216

  Fly   682 INAEKVNALC---TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRR 743
            ...|....|.   .|||||||.||..|.|::|..:.:.::||.||.|..|:::..|.|:.||.|:
Mouse   217 AYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQ 281

  Fly   744 LGHEHSFHIMTRLLAGAAGLLQKELHLENITSED--SHPFISLSQKLEDRHRAANDFMRTVQAFE 806
            ...|.:|||...|||||...::.:|.||:..|..  |:.|:.:....:|..     |..|::|..
Mouse   282 ARDERTFHIFYYLLAGAKEKMKSDLLLESFNSYTFLSNGFVPIPAAQDDEM-----FQETLEAMS 341

  Fly   807 TLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAF 871
            .:..:.:....|..:::::..||  .:......:|.:....:.|||:|...|:|:|:.|.:.|
Mouse   342 IMGFNEEEQLAILKVVSSVLQLG--NIVFKKERNTDQASMPDNTAAQKVCHLVGINVTDFTRA-- 402

  Fly   872 GLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIM 936
             :..|....|.....|:.|.    |.|...:|||....|......:::.:|:.:..:....||.:
Mouse   403 -ILTPRIKVGRDVVQKAQTK----EQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFL 462

  Fly   937 -LIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVE 991
             ::|..||:    |          :...|..||..|:||.||:||..:..::.|.:|     .::
Mouse   463 GILDIAGFEIFEVN----------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFID 517

  Fly   992 IEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF 1056
            ..:||.      |.|.||:               |.::..|:|.|||||..:|.:.|.:|:|:|.
Mouse   518 FGLDLQ------PCIELIE---------------RPNNPPGVLALLDEECWFPKATDKSFVEKLC 561

  Fly  1057 SHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEIN 1121
            |..|:.......::.....:|.:.|..|  .|.|....|:..:.: |...|..|||..||.:
Mouse   562 SEQGNHPKFQKPKQLKDKTEFSIIHYAG--KVDYNASAWLTKNMD-PLNDNVTSLLNASSDK--- 620

  Fly  1122 RLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLR 1186
              ::..|.:....:|      ||:....:...|....|.|..|:.|....| .|..:..::.|||
Mouse   621 --FVADLWKDVDRIV------GLDQMAKMTESSLPSASKTKKGMFRTVGQL-YKEQLGKLMTTLR 676

  Fly  1187 RTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLH 1249
            .|..:||.|.:..|  .:||                       ::..|:..|||.:.|||..|:.
Mouse   677 NTTPNFVRCIIPNHEKRSGK-----------------------LDAFLVLEQLRCNGVLEGIRIC 718

  Fly  1250 RLGFPESVPLLEFVRRFGLLAGD-----LASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVL 1309
            |.|||..:...||.:|:.:||.:     ....|...:..|.|: |||...||||.|:|.||:|||
Mouse   719 RQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKAL-ELDPNLYRIGQSKIFFRTGVL 782

  Fly  1310 SELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVR 1374
            :.||.:||:.::|.|:..||.||||||||..::|:.|..|::.||||..|:|.:|:|.||||..:
Mouse   783 AHLEEERDLKITDVIMAFQAMCRGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTK 847

  Fly  1375 VTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLE-----------------AK 1422
            |.|||.|.|.||:::...||:..::.:.:|.|.:..|::.::.:|.                 |:
Mouse   848 VKPLLQVTRQEEEMQAKEEEMQKIKERQQKAETELKELEQKHTQLAEEKTLLQEQLQAETELYAE 912

  Fly  1423 LSELTVDLA----EERSTAHIATERLEAE-------TAERLKLEKELGDQTNKVKNLQETTEKLE 1476
            ..|:.|.||    |.....|....|||.|       .|||.|:.:::.|...:::..:...:||:
Mouse   913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977

  Fly  1477 MELICAK-------------------------------SDL--NGISEDEDAENEDGVGGGVYKL 1508
            :|.:.|:                               |||  |...|:|.|:|...:     |.
Mouse   978 LEKVTAEAKIKKLEDDILVMDDQNSKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKL-----KS 1037

  Fly  1509 KYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNE 1573
            |:|.:..|||...::    .|...::|..||:.||...||.:|::.:.:..:.:.|.:..|...|
Mouse  1038 KHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098

  Fly  1574 MNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREK----DVLQAEKFTLE 1634
            :......|:|:.|:.|...||.|:.:.....||:.:..||.|:.:..::|    :.|:|.|..||
Mouse  1099 LQAALARLDEEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163

  Fly  1635 QTLADTRLDLEF---KEEKLASLQRELEEMTFGGGTE----------------EEFAQLRRSKNE 1680
            .||..|....|.   :|:::..|::.|:|.|.....:                |:..|.:|:|..
Mouse  1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKAN 1228

  Fly  1681 TERRAKEQEEELDEMAGQIQLLEQA-------KLRLEMTLETMR------KEARRESQQRDEELE 1732
            .::..:..|:|..::||::::|.||       |.:||:.|:.::      :.||.|...:..:|:
Mouse  1229 LDKSKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQ 1293

  Fly  1733 -----------EVRGNGYKKIK---ALECQLETEHE---ERTLLLREKHELERRLSSMED----- 1775
                       |..|...|..|   :|..||:...|   |.|   |:|..:..:|..:||
Mouse  1294 NEVESVTGMLNEAEGKAIKLAKDVASLGSQLQDTQELLQEET---RQKLNVSTKLRQLEDERNSL 1355

  Fly  1776 RDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLE--------------RLKADTPGKTLIRQLR 1826
            :|::|.:.|  ..|.|.|.:......|.|::.:|:              ||:.:..|      |.
Mouse  1356 QDQLDEEME--AKQNLERHVSTLNIQLSDSKKKLQDFASTIEVMEEGKKRLQKEMEG------LS 1412

  Fly  1827 NQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERAN----------------AAH 1875
            .|.|:..:|.....|.:...:.||.::....|...:..::.|::..                |..
Mouse  1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAEEKNISSKYADE 1477

  Fly  1876 RDRAELQAQIEENE--------EELGELMKKYSATVKQLNTEQ-----------INVSEAEFKLN 1921
            |||||.:|:.:|.:        ||..|..::...|.|.|..|.           .||.|.|....
Mouse  1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542

  Fly  1922 EMEAERNNLKEQVAELQHRLDNVENLG---DPSMAMMSKRLELRTKELESRLELEQATRARLEVQ 1983
            .:|.:...:|.|:.||:..|...|:..   :.:|..:..:.|   ::|::|.|..:..|.:|:.|
Mouse  1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQ 1604

  Fly  1984 VNRHKEALE--------------KLQNEVTQSKMREMQAQDVIK----------KSQKSLRDMRE 2024
            ::.::..||              ||:.::   |..|:||...||          |.|..::|.:.
Mouse  1605 LHEYETELEDERKQRALAAAAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

  Fly  2025 EFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLA--LQRIADLQQAMEEEGEEELSESD 2087
            |.....:...|.....|:.|||.:.:|::...|:.||..|  .::.|||:   :||..|||:
Mouse  1667 ELDDARASRDEIFATSKENEKKAKSLEADLMQLQEDLAAAERARKQADLE---KEELAEELA--- 1725

  Fly  2088 ESLSSVGSISD----LEDRLRPVHVKRSSQQSLNGSIGGGGGSVVSSTR----TVVFEKDDN--- 2141
            .|||...::.|    ||.|:..:..:...:|         |.....|.|    |:..|:..|
Mouse  1726 SSLSGRNTLQDEKRRLEARIAQLEEELEEEQ---------GNMEAMSDRVRKATLQAEQLSNELA 1781

  Fly  2142 SPRITVTSPSSPHIHKLALAAKAIPANKPDTKPAASTRMELTVPA 2186
            :.|.|.....|.. .:|....|.:.:...:.:.|...:::.||.|
Mouse  1782 TERSTAQKNESAR-QQLERQNKELRSKLQEVEGAVKAKLKSTVAA 1825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	240/793 (30%)
		MYSc_Myo18	575..1305	CDD:276837	223/762 (29%)
		GBP_C	<1540..1750	CDD:303769	60/259 (23%)
		COG1340	1565..1833	CDD:224259	78/339 (23%)
		coiled coil	1723..1734	CDD:293879	2/21 (10%)
Myh11	XP_006521906.1	Myosin_N	33..71	CDD:367160	10/43 (23%)
		MYSc_class_II	99..778	CDD:276951	223/762 (29%)
		Myosin_tail_1	855..1935	CDD:366712	226/1013 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810