DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Myh1

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_109604.1 Gene:Myh1 / 17879 MGIID:1339711 Length:1942 Species:Mus musculus


Alignment Length:1807 Identity:454/1807 - (25%)
Similarity:788/1807 - (43%) Gaps:380/1807 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   542 GEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAP 606
            |..:||.:|.|...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:|...:.|||...
Mouse    67 GTTVTVKDDQVYPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

  Fly   607 LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL 671
            |.:|:.:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:||:.:.|..:.|.
Mouse   132 LPVYNAEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

  Fly   672 ALAAGAYNNFINAEKVNALCT-----------------ILEAFGNTKTCLNSNATRMTQLLSLDF 719
            |..|      :..||.....|                 :||||||.||..|.|::|..:.:.:.|
Mouse   197 ATIA------VTGEKKKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF 255

  Fly   720 DQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISL 784
            ..||::|||.::..|.|:.|...:|..|.|:||..::::.....|.:.|.:  .|:...:.|:|.
Mouse   256 GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLI--TTNPYDYAFVSQ 318

  Fly   785 SQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQ 845
            .:    .::|:    .:.|.|..|.:.|...:.....|:.:..|:.|.|     .:......|.:
Mouse   319 GEITVPSIDDQ----EELMATDSAIDILGFTSDERVSIYKLTGAVMHYG-----NMKFKQKQREE 374

  Fly   846 FANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVI 907
            .|.|   ..|.||:.|..:|..||..|   |..|....|....:|..|.    :..:..:.||..
Mouse   375 QAEPDGTEVADKAAYLQNLNSADLLKA---LCYPRVKVGNEYVTKGQTV----QQVYNSVGALAK 432

  Fly   908 GLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQER 968
            .:|.:....:|..||:|:.|.......|.::|..||:    |          :|..|..|:..|:
Mouse   433 AVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLCINFTNEK 487

  Fly   969 LQMLFHHTTLVAPRDRYAQELVEIE-----MDLASECHPGPLISLIDKAPQNHVVRSSQRDLREH 1028
            ||..|:|...|..::.|.:|.:|.|     ||||: |     |.||:|.                
Mouse   488 LQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAA-C-----IELIEKP---------------- 530

  Fly  1029 DRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAG--PRQFVLHHLQGTNPVLY 1090
              .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|  ...|.|.|..||  |.|
Mouse   531 --MGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAHFSLVHYAGT--VDY 591

  Fly  1091 AVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQ----SLR 1151
            .:.||:..::: |.....|.|.|.||.:.:..|:.|:   .:.|....|...|.:|.:    |.:
Mouse   592 NIAGWLDKNKD-PLNETVVGLYQKSSMKTLAYLFSGA---AAAAEAESGGGGGKKGAKKKGSSFQ 652

  Fly  1152 RVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSS 1216
            .||::.|.                 .::.::..||.|..|||.|.:                |:.
Mouse   653 TVSALFRE-----------------NLNKLMTNLRSTHPHFVRCII----------------PNE 684

  Fly  1217 AAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGDLAS 1275
            .....:.|.|:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|....
Mouse   685 TKTPGAMEHELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFID 744

  Fly  1276 NKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR--- 1337
            :|..| |::|...::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||||||   
Mouse   745 SKKAS-EKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGYLARVEY 808

  Fly  1338 KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKL 1402
            :||.:||.   ::.|||.||:||:.|:.|||.:|..::.|||....||:::....||....:..|
Mouse   809 QKMVERRE---SIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKAKENL 870

  Fly  1403 EKIECDRSEVK--------------------------AENQ---------KLEAKLSELTVDLAE 1432
            .|.|..|.|::                          ||.:         :||||:.|:| :.||
Mouse   871 AKAEAKRKELEEKMVALMQEKNDLQLQVQSEADSLADAEERCDQLIKTKIQLEAKIKEVT-ERAE 934

  Fly  1433 ERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAE 1496
            :.       |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..::|:    
Mouse   935 DE-------EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE---- 988

  Fly  1497 NEDGVGGGVYKLKYERVA---------RELE--------FTKRRLHTQHEHD-----LEQ----- 1534
             ..|:...:.||..|:.|         .:|:        .||.::..:.:.|     |||     
Mouse   989 -MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIR 1052

  Fly  1535 --LVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRK 1597
              |...|:.||..|..|.|..::......|...|.:|...||::|:..:|::.|....|:||.::
Mouse  1053 MDLERAKRKLEGDLKLAQESTMDVENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKIKE 1117

  Fly  1598 FDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEFKEEKLASLQ--- 1655
            ..|..:.|::.:..||.::.:..:::..|..|...:.:.|.:    |...:|..:::.|..|   
Mouse  1118 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1182

  Fly  1656 RELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQ 1704
            |:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|::|..::::.:
Mouse  1183 RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMEVISK 1247

  Fly  1705 AKLRLEMTLETMRKE-----ARRESQQR-DEELEEVRGNGYKKIKALECQLETEHEERTLLLREK 1763
            :|..||....|:..:     .:.|.||| ..||...||           :|:||..|.:..|.||
Mouse  1248 SKGNLEKMCRTLEDQVSELKTKEEEQQRLINELTAQRG-----------RLQTESGEYSRQLDEK 1301

  Fly  1764 HELERRLSS-----MEDRDRVDRDAEEALN---------QKLRRD---LRKYKALLKDAQTQLER 1811
            ..|..:||.     .:..:.:.|..||.:.         |..|.|   ||:.....::|:.:|:|
Mouse  1302 DSLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQR 1366

  Fly  1812 LKADTPGKTLIRQLRNQLE-DA--------ESARSLAMK---ARQTAEAELTEVQAMFDESHRAR 1864
              |.:...:.:.|.|.:.| ||        |:.:.||.:   |.:..||...:..::.....|.:
Mouse  1367 --AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1429

  Fly  1865 NDAE------ERANAA---------HRDR--AELQAQIEENEEELGELMKKYSATVKQLNTEQIN 1912
            |:.|      ||.|||         :.|:  ||.:.:.||...|| |..:|.|   :.|:||...
Mouse  1430 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAEL-EASQKES---RSLSTELFK 1490

  Fly  1913 VSEA-EFKLNEMEA----------ERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKEL 1966
            :..| |..|:.:|.          |.::|.||:||...|:..:|.:        .|::|....||
Mouse  1491 IKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI--------KKQIEQEKSEL 1547

  Fly  1967 ESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQ-KSLRDMREEFHAVS 2030
            ::.||..:|:....|.::.|.:..|.::::|:.:....:.:..|.:|::. :.:..|:....|..
Mouse  1548 QAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEI 1612

  Fly  2031 SREQESLTRRKDLEKKVEQMESE--------GAALKN-----------------------DLR-- 2062
            ....:::..:|.:|..:.:||.:        ..||:|                       ||:  
Mouse  1613 RSRNDAIRLKKKMEGDLNEMEIQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQ 1677

  Fly  2063 LAL-QRIADLQQAMEEEGEEELSESDESLS-SVGSISDLEDRLRPVHVKRSS 2112
            ||: :|.|:|.||..||....|.:::.|.. :...:.|..:|::.:|.:.:|
Mouse  1678 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 211/806 (26%)
MYSc_Myo18 575..1305 CDD:276837 199/775 (26%)
GBP_C <1540..1750 CDD:303769 53/238 (22%)
COG1340 1565..1833 CDD:224259 74/322 (23%)
coiled coil 1723..1734 CDD:293879 6/11 (55%)
Myh1NP_109604.1 Myosin_N 35..73 CDD:367160 2/5 (40%)
MYSc_Myh1_mammals 100..773 CDD:276875 199/775 (26%)
Actin-binding. /evidence=ECO:0000250 662..684 8/37 (22%)
Actin-binding. /evidence=ECO:0000250 764..778 3/13 (23%)
Myosin_tail_1 853..1930 CDD:366712 205/915 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1156..1175 3/18 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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