DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Il16

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001347016.1	Gene:	Il16 / 16170	MGIID:	1270855	Length:	1424	Species:	Mus musculus

Alignment Length:	1487	Identity:	285/1487 - (19%)
Similarity:	448/1487 - (30%)	Gaps:	514/1487 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GDEDKERRKREKKLRKEAKGTSGGPGMGGVTGVTGSMSTDELLRLDEVRRSLKIRGRR------K 68
            |::::::|.....||.|..|.||              .:.:..:...:.|||.:...:      .
Mouse    88 GEQERKKRGLTSSLRMEPHGHSG--------------KSRKSTKFRSISRSLILCNAKTSDDGSS 138

  Fly    69 EKEKLPSGITADYS-------------ADFF-AALN--ADANGGSNGGAVGAADPEQDRGNEEIV 117
            ..||.|........             ||.| |.|:  .|....|:...:.||.  .|||..
Mouse   139 PDEKYPDPFETSLCQGKEGFFHSSMQLADTFEAGLSNIPDLALASDSAQLAAAG--SDRGKH--- 198

  Fly   118 ASVMTHIESRASNGAGVSVNYSEVTHSLLSGGLKNRFLPPIPPKPPKRGILKGSRSNMTNVHE-- 180
            ...|..::..:|..:.......|...|        .||.|       :...:.:|||.|:|:.
Mouse   199 CRKMFFMKESSSTSSKEKSGKPEAQSS--------SFLFP-------KACHQRTRSNSTSVNPYS 248

  Fly   181 --EISFAGSAGGAGGT---PEMLLRN-------------------------------------TF 203
              ||.|..:...|..|   |..|..|                                     ..
Mouse   249 AGEIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDYPILGTARPTRSLSTAQLGQLSGGLQASVI 313

  Fly   204 QNESLYEGAARGAG--SIGSNSSQHGTSFTSVES-------------------LRSDGEQTGG-- 245
            .|..|.:|.|:|.|  .:|...|.:|.....|:|                   |..:||...|
Mouse   314 SNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESMAGLT 378

  Fly   246 -----------QQRAMTLPANARYGALPQGNSQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSL 299
                       ::..:||....|....|   |..|||    || |...||:.:|..:..:.||||
Mouse   379 HQDALQKFKQAKKGLLTLTVRTRLTTPP---SLCSHL----SP-PLCRSLSSSTCGAQDSSPFSL 435

  Fly   300 SPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTE 364
                                 |.|..|....|  |..::::  :.|.:::.|..|...:|
Mouse   436 ---------------------ESPASPASTAK--PNYRIMV--EVSLKKEAGVGLGIGLC----- 470

  Fly   365 SLTSPIFRPV--IFA---EPGAGGGATGLLP-GDRLIKVNGTPVGEL-------------PREII 410
              :.|.|:.:  ||.   .||:.....|.|. ||.::::|.:||..|             |..:.
Mouse   471 --SIPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEINDSPVHCLTLNEVYTILSHCDPGPVP 533

  Fly   411 IEMIRNSGEAVTVE--VQPVAELVE------------------LSKRCMAPSTATVEEIDHSITN 455
            |.:.|:....|:.:  .:.||:.||                  |........|...|...||...
Mouse   534 IIVSRHPDPQVSEQQLKEAVAQAVEGVKFGKDRHQWSLEGVKRLESSWHGRPTLEKEREKHSAPP 598

  Fly   456 GNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIR 520
                  .|.|.|...|.|...:...|...|.....|       |:....||....|.
Mouse   599 ------HRRAQKIMVRSSSDSSYMSGSPGGSPCSAG-------AEPQPSEREGSTHS-------- 642

  Fly   521 LPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICEL--------------KY 571
             |:.|.|.::|....:......|...:.| .:|:::.|.|.|.:....|              ||
Mouse   643 -PSLSPGEEQEPCPGVPSRPQQESPPLPE-SLERESHPPLRLKKSFEILVRKPTSSKPKPPPRKY 705

  Fly   572 L-NEASVLHCLRQRYASNLIHTKAGPTLLV----VNPMAPLSLYSEKVVSMFRGCKTEDMPPHVY 631
            . |::.....|.::   ..:...:|.||..    ...:.||.|..:   :..|...|....|...
Mouse   706 FKNDSEPQKKLEEK---EKVTDPSGHTLPTCSQETRELLPLLLQED---TAGRAPCTAACCPGPA 764

  Fly   632 SLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEK--------VN 688
            :..||:..:..|:||..|.......|       ||.| ....|...|:..|.||.        :.
Mouse   765 ASTQTSSSTEGESRRSASPETPASPG-------KHPL-LKRQARMDYSFDITAEDPWVRISDCIK 821

  Fly   689 ALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIM 753
            .|.:.:.:..::.|.|..|    |.|...|..|.           .||   .|  |....:.:..
Mouse   822 NLFSPIMSENHSHTPLQPN----TSLGEEDGTQG-----------CPE---GG--LSKMDAANGA 866

  Fly   754 TRLLAGAAGLLQKE---------------LHLENITSEDSHP-----FISLSQKLED----RHRA 794
            .|:...|.|...|:               ..|.|...:...|     .|..:....|    :.:|
Mouse   867 PRVYKSADGSTVKKGPPVAPKPAWFRQSLKGLRNRAPDPRRPPEVASAIQPTPVSRDPPGPQPQA 931

  Fly   795 ANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLL 859
            ::...:.:.:||.........||:..:             .|...|...|:|.......:.||||
Mouse   932 SSSIRQRISSFENFGSSQLPDRGVQRL-------------SLQPSSGETTKFPGKQDGGRFSGLL 983

  Fly   860 G-----------VNLEDLSSAAFGLTQ------PNAPNGGLSPSKSPTSDTGHEWAWECLEALVI 907
            |           ..:|.:|:.....::      |.:|..|..||
Mouse   984 GQGATVTAKHRQTEVESMSTTFPNSSEVRDPGLPESPPPGQRPS--------------------- 1027

  Fly   908 GLYSEALAAVVALINRQICTSSHTIASIMLIDT--PGFQNPASCGQQVGATLADLRHNYLQERLQ 970
               ::||:....|  |.:.|.|.        ||  ||.:.|:...:....|           |.|
Mouse  1028 ---TKALSPDPLL--RLLTTQSE--------DTQGPGLKMPSQRARSFPLT-----------RTQ 1068

  Fly   971 MLFHHTTLVAPRDRYAQELVEIEMDLASE------CHPGPL----ISLIDK---APQNHVVRSSQ 1022
            ..  .|.|:   |..|.:|..|...|:|.      |.|..:    |:.|.|   :|::....||.
Mouse  1069 SC--ETKLL---DEKASKLYSISSQLSSAVMKSLLCLPSSVSCGQITCIPKERVSPKSPCNNSSA 1128

  Fly  1023 ------------------RDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLR 1069
                              .:|||:         .|....|...:            ||.|.|
Mouse  1129 AEGFGEAMASDTGFSLNLSELREY---------SEGLTEPGETE------------DRNHCS--- 1169

  Fly  1070 KCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGA 1134
            ..||  |.|:..|.               :.|...:...|.:|.:::.::::.:::..|.:..||
Mouse  1170 SQAG--QSVISLLS---------------AEELEKLIEEVRVLDEATLKQLDSIHVTILHKEEGA 1217

  Fly  1135 --------------------MVFCGSFAGLEGT-QSLRRVSSIRRSFTTAGVKRN---SIMLQVK 1175
                                .||....|..||| |....|.||... :..|...|   :|:.|.:
Mouse  1218 GLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK-SLKGATHNDALAILRQAR 1281

  Fly  1176 FTVDGIIDTLRRT--GTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNV 1230
            .....:|.|.|.|  .||.::            ..|.:.:.:|||..:|.|.:...|
Mouse  1282 DPRQAVIVTRRTTVEATHDLN------------SSTDSAASASAASDISVESKEATV 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	22/107 (21%)
		MYSc	556..1317	CDD:214580	151/802 (19%)
		MYSc_Myo18	575..1305	CDD:276837	144/768 (19%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Il16	NP_001347016.1	PDZ_signaling	316..391	CDD:238492	14/74 (19%)
		PDZ_signaling	454..536	CDD:238492	20/88 (23%)
		Atrophin-1	<620..931	CDD:331285	66/361 (18%)
		PDZ_signaling	1206..1283	CDD:238492	17/77 (22%)
		PDZ_signaling	1328..1409	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900