DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and AgaP_AGAP000121

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_311023.5	Gene:	AgaP_AGAP000121 / 1272145	VectorBaseID:	AGAP000121	Length:	861	Species:	Anopheles gambiae

Alignment Length:	435	Identity:	98/435 - (22%)
Similarity:	144/435 - (33%)	Gaps:	152/435 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GGPGMGGV-----TGVTGSMST------------DELLRL-DEVRRSLKIRGRRKEKEKLPSGIT 78
            ||...||:     :|.|...|.            ||||.| ||....|:.....:|:|.....:.
Mosquito   465 GGYECGGIEPELESGTTFDSSVFALENGTEVASGDELLLLDDEPHAELEQEEEEEEEEDGEELLG 529

  Fly    79 ADY-----------------------SADFFAALNADANGGSNGGAVGAADPEQDRGNEEIVASV 120
            |.|                       :.|..:.....|.|.|.|...|  ||...|.:.|:..|.
Mosquito   530 ARYANGTMGLPPPPPSPPPPIRTSPPTGDSDSCDTRTARGRSAGDEPG--DPTVQRWSREVPHSQ 592

  Fly   121 MTHIESRASNGAGVSVNYS-EVTHSLLSGGLKNR---FLPPIPPKPP--KRGILK-GSRSNMTNV 178
            :...:.|...|.|:|:..: ||     .||::.|   ::..|....|  :.|.|| |......|.
Mosquito   593 IVVADIRKLAGLGISLEGTVEV-----EGGVEVRPHHYIRSILEDGPVGRDGQLKPGDELLQVNE 652

  Fly   179 H--------------EEISFAGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGSIGSNSSQHGTS 229
            |              :|:........|.|:....:.||.:|...:|..:..||.:
Mosquito   653 HRLQGLKHIEVVKILKELPAQVRVICARGSSPPTVINTSRNAEAFEARSLLAGGL---------- 707

  Fly   230 FTSVESLRSDGEQTGGQQRAMTLPANARYGALPQGNSQGSHLHVLTSPSPSADSLTDTTNSSFAT 294
             .|::||:                     |.|.:..|:.|   :.||   |..:|||...|
Mosquito   708 -QSLQSLQ---------------------GILTKAQSESS---LYTS---STATLTDQQRS---- 740

  Fly   295 PPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAIC 359
                 ..|.:..|:..|.....:.|:|                      |:.| .||||:
Mosquito   741 -----KSVEQVSGLALWTHEVLYCDIE----------------------KTER-GFGFSI----- 772

  Fly   360 LDRTESL----TSPIFRPVIFAEPGAGGGATG-LLPGDRLIKVNG 399
            ||..:.|    |..:.|.:|   ||.....|. :.|||||:.|||
Mosquito   773 LDYQDPLDTDGTVIVVRGLI---PGGSAETTNFIFPGDRLVSVNG 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	23/66 (35%)
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
AgaP_AGAP000121	XP_311023.5	PDZ_signaling	17..89	CDD:238492
		PDZ	264..350	CDD:214570
		PDZ	593..682	CDD:214570	19/93 (20%)
		PDZ	755..844	CDD:214570	25/91 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900