DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and AgaP_AGAP000209

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_310924.4	Gene:	AgaP_AGAP000209 / 1272056	VectorBaseID:	AGAP000209	Length:	1068	Species:	Anopheles gambiae

Alignment Length:	976	Identity:	192/976 - (19%)
Similarity:	294/976 - (30%)	Gaps:	334/976 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 KRGILKGSRSNMTNVHEEI-SFAGSAGGAGGTPEMLLRNT--FQNESLYEGAARGAGSIGSNSSQ 225
            |:|:...|.:..:.|.... :..|..||.||.   :|..|  |.|        .|.|...||.|.
Mosquito     7 KKGVAASSGTTTSCVSSSTGTLKGGGGGGGGG---MLSKTCKFSN--------GGNGGSSSNQSS 60

  Fly   226 HGTSFTSVESLRSDGEQTG--GQQRAMTLPAN---ARYGALPQGNSQ-GSHLHVLTSPSPSADS- 283
            :|:|.:|..|..|:|..:.  ....|.|...|   ...|.|||..:| ||......||:.|.||
Mosquito    61 NGSSSSSSNSSNSNGHSSSVLDDSSAETSFINHHQGTNGTLPQDGAQPGSASDRAMSPAQSEDSG 125

  Fly   284 LTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQKSPRQ 348
            |.....:::||                         :.:|....|:       .:|:    :.|.
Mosquito   126 LAADRGTTYAT-------------------------ISIPRDSGQI-------GIVL----AERN 154

  Fly   349 DFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNG-TPVGELPREIIIE 412
            |..|.       ...||::.|:              |..|.||||:.:|:| :.:|...::|...
Mosquito   155 DLSFP-------PMVESISGPV--------------ADLLAPGDRIHQVDGVSTIGLSNQQIFSI 198

  Fly   413 MIRNSGEAVTVEVQ-PVAELVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHE 476
            :....|.|| :|:: ...|.:..:..|:....|.:             |:.|            |
Mosquito   199 LCHGEGPAV-IEIEYSFPEYISQNSLCVTTKIAQI-------------TVER------------E 237

  Fly   477 NG------NGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLS 535
            ||      .||||                   .|..|..|...|       |...:|:.:.....
Mosquito   238 NGCLGLTLRGGGE-------------------YPLVVTNVRMNG-------PVFKTGQIKPGDRV 276

  Fly   536 LRLLHNGEQLTVDEDDV---EKQNSPALDLVEDICELKYLN-----EASVLHCLRQRYASNLIHT 592
            ||:           |:|   .|..|.|..:::|:....|.|     :.||:         ..:..
Mosquito   277 LRV-----------DNVSLLNKSLSEAQHILKDVHASGYTNLMIEYDVSVM---------QTVEL 321

  Fly   593 KAGPTLL-VVNPMAP-----LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLI 651
            ..||.|| :..||..     ||.||..|              ::..:..::|: |.|.:.|...|
Mosquito   322 SMGPLLLEIERPMNEKLGLILSNYSSAV--------------NLNDIYHSSYK-LNEVQPDGIFI 371

  Fly   652 -------FMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKV-NALCTILEAFGNTKTCLNSNA 708
                   ...|.|              ||..|.....|:...| |.:||:.||    ...|::|.
Mosquito   372 ASILPASIADRCG--------------ALTVGDQILSIDESVVDNGVCTLEEA----TALLDANC 418

  Fly   709 TR-MTQLLSL---------------------DFDQTGQIASASLQVLLPERQRAGRRLGHEHSFH 751
            .: .|||..|                     ..|....:||..       ..:..|||..:.|..
Mosquito   419 VKGYTQLHILPAHMFVRRRGISCSSPRYGFNTVDSRKNLASGG-------NSKHARRLLRKSSLP 476

  Fly   752 IMTR--LLAGAAGLLQKE-LHLENITSEDSHPFIS--------------LSQKLEDRHRAANDFM 799
            ....  ||..:.||.:.| :||....|..|...:.              |...:.:|........
Mosquito   477 QTAEDGLLQSSGGLCRAEKIHLILDCSAGSGICLGPKTACGRGFLIAQILPDSVAERSGCLQKGD 541

  Fly   800 RTVQAFETLNIDAKAVRGIWS-----ILAAIYHLGIAGVTKLGTGSTA-----RTQFANPTAARK 854
            |.:...:..::|..|.|.:..     .:|..||         ....|:     ..:|....|...
Mosquito   542 RLIAINKLRDLDVNAARQLLGDYGPVTVANHYH---------NQAPTSHWVELEVEFDMADAVVP 597

  Fly   855 ASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGH------------------------ 895
            |||:..:.|...|....|:|.....:|....|:.......|
Mosquito   598 ASGVFNIKLRKQSRCGLGITVNGNAHGSFLISEVKPGSAAHRTGSLRAGDLLMAVDNRPLQHYNL 662

  Fly   896 -----EWAWECLEALV----------------IGLYSEALAAVV----ALINRQICTSSHTIASI 935
                 |...||:...|                .|||..|..:..    .::.....|.|:.|...
Mosquito   663 DLLLKESKNECITLTVKRNSLPDFLYDAQQKPAGLYGSAEESGAYTDGTMLKMNSSTESYAIEDQ 727

  Fly   936 M----LIDTPGFQN-PASCGQQVGATLADLRHNYLQERLQMLFHH--TTLVAPRDRYAQELVEIE 993
            :    ...||.:.. |...||..|...|..:.....|.|.:...|  |....|.|....:::..:
Mosquito   728 LRRPVWSSTPSYDGAPMGTGQGTGTLKAPTQPGGSAEHLPLPPAHLLTMDSEPADDRYDDILHYK 792

  Fly   994 M 994
            |
Mosquito   793 M 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	21/87 (24%)
		MYSc	556..1317	CDD:214580	104/563 (18%)
		MYSc_Myo18	575..1305	CDD:276837	99/539 (18%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
AgaP_AGAP000209	XP_310924.4	PDZ	136..212	CDD:214570	24/133 (18%)
		PDZ_signaling	231..310	CDD:238492	25/140 (18%)
		PDZ_signaling	325..414	CDD:238492	27/121 (22%)
		PDZ_signaling	496..561	CDD:238492	10/64 (16%)
		PDZ_signaling	601..679	CDD:238492	10/77 (13%)
		PDZ_signaling	844..925	CDD:238492
		PDZ_signaling	983..1063	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900