DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myo18b

DIOPT Version :10

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_017945491.2 Gene:myo18b / 100496668 XenbaseID:XB-GENE-876492 Length:2294 Species:Xenopus tropicalis


Alignment Length:1989 Identity:614/1989 - (30%)
Similarity:1035/1989 - (52%) Gaps:255/1989 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   325 PPVQLVKLPPPRQLVIRRQKSPR-------QDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAG 382
            ||   ||...|::.:    :||.       |.|.|.....:.::..|.:.|   :..:|.. |..
 Frog    60 PP---VKQEHPQESI----RSPGKLSESLVQQFVFKDENILAVEEEEEMAS---KNNLFMN-GLN 113

  Fly   383 GGATGLLPG---DRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVE--------LSK 436
            |...   ||   ::..|:|..         :.::.:.:.:||:.|.:|..|:.|        ||.
 Frog   114 GDKH---PGQATEKTSKINLN---------LNDITKVAKKAVSPEPKPSTEVAETLKEAAETLSS 166

  Fly   437 RCMAPSTATVEEID------------HSITNGNCNTLRRSASKRFKRQSRHENG-----NG-GGE 483
            .|.:|....:|.:.            ..|.......|.:..:...:....|:|.     || ..:
 Frog   167 TCRSPDLVQIENMQAAEDTVPEVIAGDDIQEKKVERLEQDTNNISEETFLHDNKVELKINGDDDD 231

  Fly   484 EGGAKGVGHDLEADVADAS--------QPERVWLVHRGGFTAAIRL------PTASSGR-----D 529
            |..||..|   |.::.|:.        :.|:||.:|..|||.|..|      |..::|:     |
 Frog   232 EAEAKNQG---EQEMTDSEKVPGDVWYETEQVWYIHNDGFTLATELKPDVGTPELAAGKVRIRID 293

  Fly   530 EENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKA 594
            |||::          |.|||:::.:.|....|..||:..|..|||:||::.||.||.|.||||.|
 Frog   294 EENRV----------LEVDEENIHRTNPSKFDYAEDLTTLISLNESSVINTLRHRYQSQLIHTSA 348

  Fly   595 GPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSG 659
            ||.|:|:.|.:|::.:|.||   |:| |.:.||||:.|:||.||.:::..|:||:::.:||||||
 Frog   349 GPNLIVLKPSSPVANFSTKV---FQG-KKDSMPPHICSVAQKAYWNMLTQRQDQTILPLGRSGSG 409

  Fly   660 KSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFG--NTKTCLNSNATRMTQLLSLDFDQT 722
            |:|..:.||.|||.|||..:|.:..||:.|:.|:|::||  .|:.|  ||:||.:.::||||:..
 Frog   410 KTTCCQSALEYLAAAAGTVDNRVTVEKIQAMFTVLKSFGCVTTREC--SNSTRFSMVMSLDFNAA 472

  Fly   723 GQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPF-ISLSQ 786
            |:|.:..||.:..||.|..::...|.:|::.|:||.||...|:.||:|..:.  |:|.| ::...
 Frog   473 GRITAGHLQTMFLERIRVAQQPQGESNFNVFTQLLGGAETDLRSELYLHQMA--DNHSFGMAPCV 535

  Fly   787 KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTA 851
            |.|::.:|:..|::...|.|.|...|...:.||.:||.|||||.||..::|     |.||.....
 Frog   536 KPEEKQKASAAFVQLQSAMEVLGFTAIEQKAIWHVLAGIYHLGAAGACRVG-----RKQFMRFEW 595

  Fly   852 ARKASGLLGVNLEDLSSAAF---------GLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVI 907
            |..|:.:||.:.|:||::.|         .:|..:........:||....||    .||:|.:..
 Frog   596 ANNAANVLGCDCEELSTSVFKHHLKQIIQQVTSGSRGGNQEDDTKSGPKMTG----VECVEGMAA 656

  Fly   908 GLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQML 972
            |||.|..||:|.||||.:.::..|:||||::|..|||||.....:..||..:|.|||:|||||.|
 Frog   657 GLYEELFAAIVTLINRCLSSTLLTLASIMVVDITGFQNPRHQKLERAATFEELCHNYVQERLQCL 721

  Fly   973 FHHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLIDK-APQNHVVRSSQRDLREHDRRGMLWL 1036
            |:..|.:...:|:.:|.:|:..|...:. |...:|:||: :.|.:|..|:|.:    :::|:||:
 Frog   722 FYSRTFLHTLERFQEENIEVAFDPPQDI-PFVTVSVIDQISSQINVQSSNQME----EKKGLLWI 781

  Fly  1037 LDEEAIYPNSNDDTFLERLFSHY---GDREHHS-LLRKCAGPRQFVLHHLQGTNPVLYAVDGWVR 1097
            ||||.:...|.|...|:||.|::   |:.::.| ..|||....||.:.|..|.:||.|.|..|:.
 Frog   782 LDEEVLIQGSTDSNVLDRLCSYFEMKGEDKYESGAFRKCEQSLQFEILHQLGKDPVRYDVTNWIN 846

  Fly  1098 HSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEG--TQSLRRVSSIRRSF 1160
            .::.:....||:.:||.|..:.:..|:   ..|....:: |.|.:|:||  .|:|:|:|.:|::|
 Frog   847 KAKLNQSAENAIQVLQQSRLDFVKDLF---APRAKFPLI-CRSVSGMEGKSQQALQRISCVRKTF 907

  Fly  1161 TT--AGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQ----------HNAGKHTKYTANGS 1213
            .:  |.|:|.|:..|:|..:|.:|:.|:|:..|||||.:.:          |...|.|.    |.
 Frog   908 ASSFAAVRRRSVCGQIKLQMDALINLLKRSQIHFVHCMVPRLGMDGSECKIHPLCKGTA----GD 968

  Fly  1214 PSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLAS--- 1275
            |.:|         :::||.:|.||..:|:|:|.||.|:|:|:.:...||..||.:||.:...   
 Frog   969 PINA---------VIDVPSVRIQLASAQLLDAMRLCRIGYPDRIGFTEFRLRFQVLASEAMKKYN 1024

  Fly  1276 ------NKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGY 1334
                  ::..:||::..:.:|:..|..:|.||:..:||||..||.:|:..:|.|::.|||.|||:
 Frog  1025 STYEPVDERKAVEELFQLLDLEKKSVVMGRSQVFLKSGVLPRLEKQREKTISQRMVLLQAACRGF 1089

  Fly  1335 LARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLR 1399
            |.|:|....::|.:|::|:|:|::.|..||.||||:::....|.|:|:..||:.|...||:.:|.
 Frog  1090 LCRQKYKNLKIQLIALKCLQKNIRKFYLVRHWPWWKIICHFRPSLSVNIDEEKFKAKQEEITVLS 1154

  Fly  1400 AKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNK 1464
            .|.:|.|..|:|::.....||:|:::||.:|::||....:..:.||.|..|||:..:|:.:...|
 Frog  1155 LKFKKSEKSRNELRQNVDLLESKITDLTTELSDERFKGEVTCQVLEVERGERLRASREIKEMQAK 1219

  Fly  1465 VKNLQETTEKLEMELICAKSDLNGISEDEDAENE-------DGVGGGV--YKLKYERVARELEFT 1520
            .:.:|:..:.:..:|             |||:.:       .|..|..  ::::::....|::|.
 Frog  1220 YEQMQKNLDSVSKQL-------------EDAQQQIQLRELNAGSSGRADEWQIRFDCAQTEIDFL 1271

  Fly  1521 KRRLHTQHEHDLEQLVALKKHLEMKLSD---AYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLE 1582
            ::|: ||.|..||...:.:|.||.|||.   |||..   ::...|..||.:.:|:::.|.|:|:|
 Frog  1272 RKRV-TQFEERLESEKSYRKDLEQKLSQLQGAYENA---KRAAQQATRKCKHLTSDLEDTRVLME 1332

  Fly  1583 EQNARNNLLEKKQRKFDAE-CQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEF 1646
            .|..||:.|||:|||||.: .|::.:|      |.|:..|||  :..|..:....:...|..||.
 Frog  1333 NQQIRNHDLEKRQRKFDMQLAQAIGEA------AFEKSLREK--VTQENTSCRWEVGKLRQSLEK 1389

  Fly  1647 KEEKLASLQRELEEM--------TFGGGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLE 1703
            ||.:.|:|.|:||.:        |..|......|.|:....|.|....||.::|.|.|..|||||
 Frog  1390 KELETANLTRQLEVLGNRVKELSTSSGLDNNSVASLKTKVWELETSVAEQNQQLTEQANAIQLLE 1454

  Fly  1704 QAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELER 1768
            |.:||.||.:|.|::...:|.:.::||||::|.:..::::..|.|||.|:||:.::|.||.:||.
 Frog  1455 QTRLRFEMEIERMKQIHLKELEDKEEELEDIRQSCQRRLRQFEMQLEQEYEEKQMVLHEKQDLEG 1519

  Fly  1769 RLSSM-EDRDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPG--KTLIRQLRNQLE 1830
            .:.:: |.....|.|.|    ::|||||::..|||.|.|..|..:....|.  :..:.::..|||
 Frog  1520 LIGTLCEQIGHRDFDVE----KRLRRDLKRTHALLADLQLLLASMGDSGPSVDRGELEKVHIQLE 1580

  Fly  1831 DAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGEL 1895
            ::|:..:.|:|.:::...||..:....:...|.:|.|:|:.....|::.||..:|:|::|:|.||
 Frog  1581 ESEAKCADALKCQKSLSMELDSLHMELENLSRNKNMADEQLFQLQREKTELLKRIDEDQEDLNEL 1645

  Fly  1896 MKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMS--KR 1958
            |||:.|.:.|...:...:.:.:.||.:.:.|:..|:|::...|.|:|.:|:    ||...|  .|
 Frog  1646 MKKHKALIAQSANDITQIRDLQTKLEDTKKEKQILQEKLQVAQSRIDYLEH----SMVERSIVSR 1706

  Fly  1959 LELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMR 2023
            .|....:|||:||.::|...|.||.:.|.::::.|:..|:..:...|.:.::..|..|..:.:|:
 Frog  1707 QEAVICDLESKLEFQRAQIKRFEVLILRLRDSMIKMGEELENAADSEAREKENAKYYQIRMEEMK 1771

  Fly  2024 EEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEE-EGEEELSESD 2087
            .|.:.:..||.|:..||.:||.:|.::.:....|:.||..:::||||||.|:|| |..::.....
 Frog  1772 VEMNELLQREMEACRRRVELETQVYELSAVRQTLQADLETSIRRIADLQAALEEVESSDDSDTER 1836

  Fly  2088 ESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGG---GGSV--------VSSTRTV------- 2134
            ::.|::||:..:..       ..|.:..:|.|....   ||||        .|.|:::       
 Frog  1837 DNESTIGSVMSMGQ-------TESVRSWVNSSASWASPTGGSVDGRLSRQSASDTQSLQSLRLKE 1894

  Fly  2135 VFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANKPDTK 2173
            :.::|.:.|..:::|....:...:........|.:||.|
 Frog  1895 MKDEDISRPSSSLSSRGKLYGSNVTAVESENTAKQPDLK 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_canonical 337..426 CDD:483948 17/98 (17%)
COG5022 541..2019 CDD:227355 515/1543 (33%)
MYSc_Myo18 575..1305 CDD:276837 270/769 (35%)
myo18bXP_017945491.2 MYSc_Myo18 329..1060 CDD:276837 270/769 (35%)
Myosin_tail_1 <1140..1810 CDD:460256 212/702 (30%)

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