Protein Alignment Rbf2 and rb1

DIOPT Version :10

• Sequence 1: NP_524372.1
• Gene: Rbf2 / 41941
• FlyBaseID: FBgn0038390
• Length: 783
• Species: Drosophila melanogaster
• Sequence 2: NP_001269454.1
• Gene: rb1 / 100493114
• XenbaseID: XB-GENE-1018165
• Length: 900
• Species: Xenopus tropicalis
• Alignment Length: 894
• Identity: 190/894 - (21%)
• Similarity: 339/894 - (37%)
• Gaps: 231/894 - (25%)

  Fly    17 FSVSCEQLELEARIQQSALSTYHRLDAVNGLSTSEADAQEWL--CCAVYSELQRSKMR-DIRESI 78
            |:|.||.|::...::..|..||.::.: :|....||..:..|  .|...:.:...:|. ...|.:
 Frog    30 FNVLCETLKISNNVRDKAWKTYEKIFS-SGYMMREATKKTELLGLCLYIASVDCEEMTFTFTELL 93

  Fly    79 NEANDSVAKNCCWNVSLTRLLRSFKMN-----------VSQFLRRMEHWNWLTQN-ENTFQLEVE 131
            .....||::  |:     ||||...:|           :|:..::.|....|.|. :.||::..|
 Frog    94 KTLTLSVSR--CF-----RLLREMDINMDVLSNKVDNAISKLKKKYETMCLLYQKFQRTFEIIFE 151

  Fly   132 ELRCRLGI--TSTLLRHYKHIFRSLFVHPGKGADPGAANHYQALYEFGWLLFLVIRNELPGFAIT 194
            |....|..  |:::|               ||.               |:.||:.|.::.... .
 Frog   152 EQHNTLASVDTASIL---------------KGT---------------WITFLLARGKILQMD-D 185

  Fly   195 NLINGCQVLVCTMDLLF---------------VNALEV---PRSVVIRREFSGVPKNWDTEDFNP 241
            :|:..||:|:|.:|...               :|||.|   |||  .||.     :|.:|.. :|
 Frog   186 DLVISCQLLLCVLDYFIKLSPPSVLKEPYKSALNALSVNTPPRS--SRRS-----QNRNTRS-SP 242

  Fly   242 ILLNKYSVLEALGELIPELPAK----GVVQMKNAFFHKALIMLYMDHSLVGDDTHMREIIKEGML 302
            .......|||.|        .|    .:.::||.:....:..|    :..|..:      .||..
 Frog   243 QSETDIKVLEIL--------CKENHCPMDEVKNVYCTSFVDFL----ASAGISS------SEGFP 289

  Fly   303 DINLENLNRKYTNQVADISEMDERVLL--------SVQGAIETKGDSPKS---------PQLAFQ 350
            .:  |:::::|........::|.|:.|        .||.:::.:....|.         ||..|:
 Frog   290 KV--ESISQQYEELYHKYKDLDARLFLENEETLKADVQDSLDLERTPRKDESEEVSIVPPQTPFR 352

  Fly   351 TSSSPSHRKLSTHDLPASLPLSIIKAFPKKEDADKIVNYLDQTLEEMNRTFTMAVKDF------- 408
            .:.:..|:...|.:..:..|            :||:.:|.:..........|..|:.|
 Frog   353 AAMNTIHQLTVTLNSASDNP------------SDKLNSYFNNCTVNPKTKVTERVEHFGHVFKEK 405

  Fly   409 -------LDAELSGKRFRQARGLYYKYLQKILGPELVQKPQLKIGQLMKQRKLTAALLACCLELA 466
                   ..||:..||::....|||:.::.||..|..:.......:|:........||||.:|:.
 Frog   406 FASSVGQACAEIGYKRYKLGVRLYYRVMEAILKTEEERLSVHNFSKLLNNDIFHMCLLACAVEVV 470

  Fly   467 L--------HVHHKLVEGLRFPFVLHCFSLDAYDFQKILELVVRYDHGFLGRELIKHLDVVEEMC 523
            :        ..:......|.||::|..|.:.|:||.|::|..::.:.. |..::||:|:..|...
 Frog   471 IDSYTRNTAQAYFSSRTNLSFPWILRVFEIKAFDFYKVIECFIKAEPS-LTSDMIKYLERCEHQI 534

  Fly   524 LDSLIFRKSSQLWWELNQRLPRYKEVD-------------------------------------- 550
            ::||.::..|.|:..:.|...|...||
 Frog   535 MESLAWQSDSPLFDLIRQTREREGLVDHPELVSTLQQPVQHNHTAADLYLSPSRSSHQCPVTSVR 599

  Fly   551 ---------AETEDKENFSTGSSICLRKFYGLANRRLLLLCKSLCLVDSFPQ----IWHLAEHSF 602
                     :.::..:..||..|:..:|.|.||.:||..||.|  |:...|:    ||.|.:|:.
 Frog   600 TSSVTNGQVSPSQPVQQKSTSLSLFYKKVYLLAYKRLSSLCSS--LLSDHPELEQVIWTLLQHTL 662

  Fly   603 TLESSRLLRNRHLDQLLLCAIHLHVRLEKLHLTFSMIIQHYRRQPHFRRSAYREVSLGNGQTADI 667
            ..| ..|:|:|||||:::|:::...:.:.:.|.|..|:..|:...:..:..::.|.:.:||...|
 Frog   663 QHE-YELMRDRHLDQIMMCSMYGICKAKNIDLRFKTIVTAYKGLTNTNQETFKHVLIRDGQHDSI 726

  Fly   668 ITFYNSVYVQSMGN----YG--RHLECAQTRKSLEESQSNVGILTETTSNELSMRANISISSPPP 726
            |.|||.|::|.:.:    ||  ||...:.. ..:..|....|       |...:..||.:|....
 Frog   727 IVFYNLVFMQKLKSHILQYGSARHPTLSPI-PHIPRSPYRFG-------NSPKVPGNIYVSPLKT 783

  Fly   727 PRVCQSGSCSSHPPSSPAASPLSLQS---SPNVKRAASSNDLMREIKRP 772
            |.....|..|....:...:..:||..   ||:  |....|.::...:||
 Frog   784 PYKTTDGLLSPSKMTPKTSFLISLGETFRSPD--RFQKINQMLNSCERP 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbf2	NP_524372.1	DUF3452	83..213	CDD:463402	31/158 (20%)
		RB_A	<384..536	CDD:460364	40/173 (23%)
		RB_B	<593..679	CDD:460363	27/89 (30%)
rb1	NP_001269454.1	DUF3452	99..202	CDD:463402	31/140 (22%)
		RB_A	349..550	CDD:460364	45/213 (21%)
		CYCLIN_RB	619..745	CDD:410302	40/128 (31%)
		Rb_C	742..897	CDD:462639	21/99 (21%)