DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pbp45 and Snapc1

DIOPT Version :9

Sequence 1:	NP_650499.1	Gene:	Pbp45 / 41920	FlyBaseID:	FBgn0038371	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_848479.1	Gene:	Snapc1 / 75627	MGIID:	1922877	Length:	389	Species:	Mus musculus

Alignment Length:	349	Identity:	69/349 - (19%)
Similarity:	129/349 - (36%)	Gaps:	76/349 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVQRFQRLVNDGENCEFEVFCRCWRELQLQHLFTAQTNHTEVIATTLAALHVAKRLSCSRRTTGD 76
            |:.|||.:    ::..||.|...||.::...:|..:..:.:....|..||.:|.|.
Mouse    33 LLSRFQEM----DSVRFEDFTELWRSMKFATIFCGKMRNLKKNMFTKEALALAWRY--------- 84

  Fly    77 VFPASRAQ-RIGGFFLLYVIYYKQPTHNFIKIEVSPRTWQELTDYALDLRKDSPERKDTHQIAYM 140
            ..|....| |:|..:|||.:|..|......||.|:.:.|.|:..:..||.  :.:..|.   |::
Mouse    85 FLPPHTFQIRVGALYLLYGLYNTQLCQPKQKIRVALKDWDEVIRFQQDLM--NAQHFDA---AFV 144

  Fly   141 LWRLTQEQAFRFTALDYCQGLDNLVDYDRVETVAGAKEQRQSALMQKQQRANGVSLTYELEGLRA 205
            ..:|..::||.|||:            .::.:....|:.:|:.:.||.:..|.          |.
Mouse   145 FRKLRLDRAFHFTAM------------PKLLSCRMKKKVQQTEVTQKFKDPND----------RV 187

  Fly   206 LDQASQPLCELEAAYNAQKKQLAAGHEHALPPSQIFGHLREVFADIQSVLGARKSTPDENCTTTS 270
            :...:..:  ||...|.        |:|              :.:::..:.|.||.||...:...
Mouse   188 MKLITSDV--LEEMLNV--------HDH--------------YQNMKHAISADKSMPDRALSLVK 228

  Fly   271 TGNQLEVRQRVRNKAMYGVEEREP------QNQADELEVQLEVNETYQRRMSSATV----FQREL 325
            ......::..|.....:..|.:.|      ::..:..|...|..|..:|.:|.|.:    |...:
Mouse   229 EDFFENIKNIVLEHQEWHKERKNPSLKPKLKDGEENGEGSSEEPERCERAVSLAKIKAKAFSAVV 293

  Fly   326 PADVQQEYEMIEF-SDDEEMEVGE 348
            |....:.:...:. |.|.:...|:
Mouse   294 PVSKSRRHRQSKLDSSDSDSGSGQ 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pbp45	NP_650499.1	SNAPc_SNAP43	5..214	CDD:286846	45/202 (22%)
Snapc1	NP_848479.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		SNAPC3-binding. /evidence=ECO:0000250	20..187		44/193 (23%)
		SNAPc_SNAP43	26..210	CDD:286846	50/240 (21%)
		SNAPC4-binding. /evidence=ECO:0000250	183..287		21/137 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..276		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..389		4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850879
Domainoid	1	1.000	46	1.000	Domainoid score	I12098
eggNOG	1	0.900	-	-		E1_KOG4746
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006114
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107544
Panther	1	1.100	-	-	LDO	PTHR15131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3936
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.730