Protein Alignment alpha-Man-IIb and man2a1

DIOPT Version :10

• Sequence 1: NP_650494.2
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_001103497.3
• Gene: man2a1 / 560219
• ZFINID: ZDB-GENE-060526-31
• Length: 1150
• Species: Danio rerio
• Alignment Length: 1144
• Identity: 393/1144 - (34%)
• Similarity: 593/1144 - (51%)
• Gaps: 190/1144 - (16%)

  Fly   148 WDRGFEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMT 212
            |.:||:..:...:.|.:  ||::.|||||||||||||||.:|::..::.|||.:|.|:.|.:...
Zfish   146 WKQGFDISYQENEWDNE--PLQVFVVPHSHNDPGWLKTFDDYYRDQTQHILNNMVVKLHEDSRRK 208

  Fly   213 FIWSEISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLK 277
            .||||||:...|||.....||.|::||::.|::|:.||||||.||||.|.:.|:|||:||||||:
Zfish   209 MIWSEISYFAKWWDSIDGQKQDAVRRLVENGQLEVATGGWVMPDEANAHYFAMIDQLVEGHQWLE 273

  Fly   278 NNLNVTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRK 342
            .||.|.||.||::|||||.:|..|||..|.....:|||:||:.|:.|:.|::.:|.|:..|
Zfish   274 RNLGVKPKTGWAVDPFGHTATQAYLLKLAGLSNMLIQRVHYSVKKHFSSQKTLEFFWRQNW---- 334

  Fly   343 DKDSEAGSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTE--YSVKAQFITDDNLESKA 405
            |:||.. .:|.|.|||..|.:..:|||.|.||..|||:::||....  :.:..|.|||:|::.:|
Zfish   335 DQDSST-DILCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRISCPWRIPPQAITDNNVQERA 398

  Fly   406 QLLLEQYARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTP 470
            |.||:||.:.:.||...|.|.|:||||||.:..|.|||::||:||.|::.::..|: ...:|||.
Zfish   399 QTLLDQYRKKSKLFRTKVLLAPLGDDFRYTEAVEWDQQFENYQKLFDYMNSHPELH-VKAQFGTI 462

  Fly   471 SDYFEAIKERMKDHTPG-------FPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELE 528
            ||||:|:::.......|       .|...||||.|:|....    |||||||:|||||.:...||
Zfish   463 SDYFQALRKSTGMDPVGMNVGHLALPVVSGDFFTYADRDDH----YWSGYFTSRPFYKRMDRMLE 523

  Fly   529 HQLRSAEIVFTLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYA 593
            ..||:||::::|.....::..:.:.....| ||:|:..||||||||||||||.||.|..|:.||.
Zfish   524 SYLRAAEVLYSLTLANIQKYGQPSDYPAGE-NYKLLTEARRNLGLFQHHDAIAGTGKDWVVVDYG 587

  Fly   594 MRLFESTQNMVKMQESCLELLLQKGQPRHH-----GFLLSEFERDNFNKLPRKMPIQMANGDEST 653
            .|||.|..|:.::..|....|:.|.:..:|     .||..:..:.:.:.||||..:::
Zfish   588 TRLFHSILNVKRVIVSSAHWLVLKDKQTYHNDPSKAFLQMDDVQQSQDALPRKNVLEV------- 645

  Fly   654 PTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWN 718
                           .|.....|:.|.|.|.|..:||:.|..|||::::..| ::...|::.||.
Zfish   646 ---------------HGKPRLLVVSNPLEQARTSMVTVYVNTPNVRVLSALG-QVVRAQVSAVWK 694

  Fly   719 ITDTYEQGLGTSVSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIYCDDCT 783
            ...                 ..:...|::.|||...||.||.|  |:.||...|..|:.|. ...
Zfish   695 DAS-----------------HATADVFQLSFVAHAAPLGLSVY--QLIEVMEPRTDASKYM-FLQ 739

  Fly   784 ESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPL 848
            |.:..|.|..|...    ..::..|.|   :.:||||:||.....:|.|:.:..|..:.|    .
Zfish   740 EGRQLSDSKLEHFR----QFYQDDGAP---VVIENPHLRLSISGATGLLEKMMLKEDESE----H 793

  Fly   849 QCNIKFAAY--RSAQFHSGAYLFKTDPE---QSEAEKEVLEGYTDMRIIITSGPIASDVTVIYGP 908
            |..::|..|  .|::..||||||..|.|   .|.::..|:.        :|.|.:.|:||..:.
Zfish   794 QMKVEFVWYGTTSSKDKSGAYLFLPDKEATIYSPSQPPVIR--------VTKGTLFSEVTTTFA- 849

  Fly   909 FLAHTVRIFNTRTHLDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDA 973
            .:.||:|::||:.....::.:.|.:|.. ...||  |:.||..:::::       :|.
Zfish   850 HITHTLRLYNTQGVEGQSVEICNTVDIR-GETNR--EIAMRITSDLNS-------KDR------- 897

  Fly   974 ATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPG 1038
                    |::|.||:|...|..:..:.::.|::|:||..::|||..||:|||..:.||||.:.|
Zfish   898 --------FFTDLNGYQVQPRKTMAKLPLQANFYPMTSMLYLQDSSARLSLLTAQSLGAASLKSG 954

  Fly  1039 QLEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVEDLPGGQHVTQPPSYKVLSQQAQQLANAL 1103
            ||||::|||...||.||:|:||:|:::|.:.|.||:|              |.:|.:..:.....
Zfish   955 QLEVIMDRRLNQDDNRGLGQGVLDNKITANSFRLLLE--------------KRISVEENEATAPY 1005

  Fly  1104 RYPPNLYFVS--NLEQPELAAAL---LPLVRLLPKGPL----PCDVHLTTLRTLSDPELQLFPSA 1159
            .||..|..:|  .|..|.::.|:   |....::|..||    |||:||..||.:...|.....|.
Zfish  1006 SYPSILSHMSYMYLNHPLISMAVSQHLEAPSVVPYSPLKASFPCDMHLVNLRAIQSKEEGGAASE 1070

  Fly  1160 SALLVLHRQGFDCSVS-----------AGR--------ELSMEAICPLSSKGLGNVQLGRLSL-H 1204
            .|.|:|||:||||..|           .|:        :|.:::|.|:|           ||| |
Zfish  1071 QAALILHRKGFDCGFSNRNTGLLCTSTRGKIDLEKLLTDLKVKSITPVS-----------LSLMH 1124

  Fly  1205 TIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNL 1243
            |:.:.|..                .||||:.||:||:.|
Zfish  1125 TLSSESRP----------------QEISLKAMEIRTYRL 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_650494.2	PLN02701	148..1246	CDD:178304	393/1144 (34%)
man2a1	NP_001103497.3	None