Protein Alignment alpha-Man-IIb and LManII

DIOPT Version :10

• Sequence 1: NP_650494.2
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Alignment Length: 1220
• Identity: 290/1220 - (23%)
• Similarity: 468/1220 - (38%)
• Gaps: 339/1220 - (27%)

  Fly   168 LKIIVVPHSHNDPGWLKTFTNYF--------QSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLW 224
            |.:.:|.|:|:|.|||||...|:        ::..:.|::.:|..:....:..||:.|.:|...|
  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111

  Fly   225 WDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVT------ 283
            |.:..|..|.|:|.|::.||:|...|.|.|.|||..|...::||.    .|....||.|
  Fly   112 WKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQF----SWGLRLLNDTFGECGR 172

  Fly   284 PKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEA 348
            |:|||.||||||...:..:.:...|:|....|:.|..|......::.:.||.......::.|..:
  Fly   173 PRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFS 237

  Fly   349 GSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFITDDNLESKAQLLLEQYA 413
            |:|..:....|.:.....|...|.|    |.:..|              |:|::.:....|: :|
  Fly   238 GALYNNYQAPDGFCFDILCNDAPII----DGKHSP--------------DNNVKERIDTFLD-FA 283

  Fly   414 RTAS-LFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNA---DIRFGTPSDYF 474
            :|.| .:..|..::.:|.||.|   :.....|:|..|||.:  .|.|..|.   ::.:.|||.|.
  Fly   284 KTQSQYYRTNNIIVTMGGDFTY---QAAQVYYKNLDKLIRY--GNERQANGSNINLLYSTPSCYL 343

  Fly   475 EAIKERMKDHTPG--FPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIV 537
            :::      |..|  :||...|||.|    :....|||:||||:||..|....:..|.|:..:.:
  Fly   344 KSL------HDAGITWPTKSDDFFPY----ASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQL 398

  Fly   538 FTLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLF----- 597
            ..||.....:         ::.:...:   |..||:.|||||||||.|..|..|||.|:.
  Fly   399 SALAPKKPEE---------FDPHLTFM---RETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRA 451

  Fly   598 --ESTQNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMAN----GDESTPTV 656
              .:|:|.:.      :|.:|              .:||......|...:...    ...|.|..
  Fly   452 CGATTRNALN------QLTVQ--------------SKDNVKDTSAKYVFEFKTCALLNITSCPVS 496

  Fly   657 PAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITD 721
            .|.:..|           ..|||.||....|.|.:.|.:.|.:|:::|||.|.. |..|:..:..
  Fly   497 EANDRFA-----------LTLYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLES-QAVPIPQVLI 549

  Fly   722 TYEQGLGTSVSGTVGRIRTSTRQFEVMFVA-ELEPLSLSTYRVQVDEVNFKRNIATIYCDDCTES 785
            ..:.             |.||.::|::|:| .:..|...||.|:.              .|.||.
  Fly   550 DIKH-------------RNSTAKYEIVFLATNIPALGYRTYYVEK--------------LDSTEG 587

  Fly   786 QPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQC 850
            ...|.:.|:...|...              :.|.|::|.|| .:|||..:|...    |.:.:..
  Fly   588 NTRSKALPKRTSSVTV--------------IGNSHIQLGFD-TNGFLSEVTADG----LTRLVSQ 633

  Fly   851 NIKF---AAYRSAQF---HSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDVTVIYGPF 909
            ...|   |...:|:|   .||||:|:.:      |.::......:.|.:..|.:..:|...:..:
  Fly   634 EFLFYEGAVGNNAEFLNRSSGAYIFRPN------ENKIHFATDQVEIEVYKGDLVHEVHQKFNDW 692

  Fly   910 LAHTVRIFNTRTH-----LDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKE 969
            ::..||::|..::     |...|.:::.|.         .|:..||.::|.:..
  Fly   693 ISQVVRVYNKDSYAEFEWLVGPIPIDDGIG---------KEVITRFNSDIASDG----------- 737

  Fly   970 PVDAATMPELPVFYSDQNGFQYHER---------IKVPAIGIEGNYFPITSGAFIQDSRLRLTLL 1025
                       :|.:|.||.:..:|         :|:.. .:.|||:|||:...::|...|:.:|
  Fly   738 -----------IFRTDSNGREMIKRKINHRDTWSVKINE-AVAGNYYPITTKIDVEDDTARMAIL 790

  Fly  1026 TTHAQGAASYEPGQLEVMLDRRTLYDDYRGMGEGVVD--------SRLTRHKFWLLVEDLPGGQH 1082
            |..|||.:|.:.|.||:|:.||.|.||..|:||.:.:        :|...|.|:....|..|
  Fly   791 TDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETEYGDGLIARGKHHLFFGKSTDREG--- 852

  Fly  1083 VTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLE-------QPELAAALLPLVRLLPKGPLPCDV 1140
                    |..:..::|....:..|...|.||:|       |.........:..:|||     .|
  Fly   853 --------VSLKGIERLTQLEKLLPTWKFFSNMEDYSADEWQTAFTNIFSGISLVLPK-----PV 904

  Fly  1141 HLTTLRTLSDPELQLFPSASALLV----LHRQGFDCSVSAGRELSMEAICPLSS---KGL----- 1193
            ||.||....:         :.|||    :...|.|.|.|...:.:::.:  ||:   :|:
  Fly   905 HLLTLEPWHE---------NQLLVRFEHIMENGEDASYSQPVQFNVKNV--LSAFDVEGIRETTL 958

  Fly  1194 -GNVQLG---RL----------------------SLHTIEATS-LTGTEQ--------KSSRESY 1223
             ||..|.   ||                      |:|.:.|.. :.|.:.        :...||.
  Fly   959 DGNAWLDESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAEKPMLGVKYADEALPAGQLGAESN 1023

  Fly  1224 HIRSLAE--------------------------------ISLEPMELRTF 1241
            .||...|                                |.|.|||:|||
  Fly  1024 RIRRETETRQEKKDEGRSSKSTEGPYNSFKSDSSNQEYIIELSPMEIRTF 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_650494.2	PLN02701	148..1246	CDD:178304	290/1220 (24%)
LManII	NP_609408.1	PLN02701	47..823	CDD:178304	235/941 (25%)
		GH38N_AMII_LAM_like	47..323	CDD:212121	82/303 (27%)