Protein Alignment alpha-Man-IIb and LManII

DIOPT Version :8

• Sequence 1: NP_001262614.1
• Gene: alpha-Man-IIb / 41913
• FlyBaseID: FBgn0026616
• Length: 1249
• Species: Drosophila melanogaster
• Sequence 2: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Alignment Length: 1220
• Identity: 290/1221 (24%)
• Similarity: 468/1221 (38%)
• Gaps: 339/1221 (28%)

  Fly   168 LKIIVVPHSHNDPGWLKTFTNYF--------QSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLW 224
            |.:.:|.|:|:|.|||||...|:        ::..:.|::.:|..:....:..||:.|.:|...|
  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111

  Fly   225 WDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVT------ 283
            |.:..|..|.|:|.|::.||:|...|.|.|.|||..|...::||.    .|....||.|
  Fly   112 WKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQF----SWGLRLLNDTFGECGR 172

  Fly   284 PKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEA 348
            |:|||.||||||...:..:.:...|:|....|:.|..|......::.:.||.......::.|..:
  Fly   173 PRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFS 237

  Fly   349 GSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFITDDNLESKAQLLLEQYA 413
            |:|..:....|.:.....|...|.|    |.:..|              |:|::.:....|: :|
  Fly   238 GALYNNYQAPDGFCFDILCNDAPII----DGKHSP--------------DNNVKERIDTFLD-FA 283

  Fly   414 RTAS-LFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNA---DIRFGTPSDYF 474
            :|.| .:..|..::.:|.||.|   :.....|:|..|||.:  .|.|..|.   ::.:.|||.|.
  Fly   284 KTQSQYYRTNNIIVTMGGDFTY---QAAQVYYKNLDKLIRY--GNERQANGSNINLLYSTPSCYL 343

  Fly   475 EAIKERMKDHTPG--FPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIV 537
            :::      |..|  :||...|||.|    :....|||:||||:||..|....:..|.|:..:.:
  Fly   344 KSL------HDAGITWPTKSDDFFPY----ASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQL 398

  Fly   538 FTLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLF----- 597
            ..||.....:         ::.:...:   |..||:.|||||||||.|..|..|||.|:.
  Fly   399 SALAPKKPEE---------FDPHLTFM---RETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRA 451

  Fly   598 --ESTQNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMAN----GDESTPTV 656
              .:|:|.:.      :|.:|              .:||......|...:...    ...|.|..
  Fly   452 CGATTRNALN------QLTVQ--------------SKDNVKDTSAKYVFEFKTCALLNITSCPVS 496

  Fly   657 PAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITD 721
            .|.:..|           ..|||.||....|.|.:.|.:.|.:|:::|||.|.. |..|:..:..
  Fly   497 EANDRFA-----------LTLYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLES-QAVPIPQVLI 549

  Fly   722 TYEQGLGTSVSGTVGRIRTSTRQFEVMFVA-ELEPLSLSTYRVQVDEVNFKRNIATIYCDDCTES 785
            ..:.             |.||.::|::|:| .:..|...||.|:.              .|.||.
  Fly   550 DIKH-------------RNSTAKYEIVFLATNIPALGYRTYYVEK--------------LDSTEG 587

  Fly   786 QPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQC 850
            ...|.:.|:...|...              :.|.|::|.|| .:|||..:|...    |.:.:..
  Fly   588 NTRSKALPKRTSSVTV--------------IGNSHIQLGFD-TNGFLSEVTADG----LTRLVSQ 633

  Fly   851 NIKF---AAYRSAQF---HSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDVTVIYGPF 909
            ...|   |...:|:|   .||||:|:.:      |.::......:.|.:..|.:..:|...:..:
  Fly   634 EFLFYEGAVGNNAEFLNRSSGAYIFRPN------ENKIHFATDQVEIEVYKGDLVHEVHQKFNDW 692

  Fly   910 LAHTVRIFNTRTH-----LDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKE 969
            ::..||::|..::     |...|.:::.|.         .|:..||.::|.:..
  Fly   693 ISQVVRVYNKDSYAEFEWLVGPIPIDDGIG---------KEVITRFNSDIASDG----------- 737

  Fly   970 PVDAATMPELPVFYSDQNGFQYHER---------IKVPAIGIEGNYFPITSGAFIQDSRLRLTLL 1025
                       :|.:|.||.:..:|         :|:.. .:.|||:|||:...::|...|:.:|
  Fly   738 -----------IFRTDSNGREMIKRKINHRDTWSVKINE-AVAGNYYPITTKIDVEDDTARMAIL 790

  Fly  1026 TTHAQGAASYEPGQLEVMLDRRTLYDDYRGMGEGVVD--------SRLTRHKFWLLVEDLPGGQH 1082
            |..|||.:|.:.|.||:|:.||.|.||..|:||.:.:        :|...|.|:....|..|
  Fly   791 TDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETEYGDGLIARGKHHLFFGKSTDREG--- 852

  Fly  1083 VTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLE-------QPELAAALLPLVRLLPKGPLPCDV 1140
                    |..:..::|....:..|...|.||:|       |.........:..:|||     .|
  Fly   853 --------VSLKGIERLTQLEKLLPTWKFFSNMEDYSADEWQTAFTNIFSGISLVLPK-----PV 904

  Fly  1141 HLTTLRTLSDPELQLFPSASALLV----LHRQGFDCSVSAGRELSMEAICPLSS---KGL----- 1193
            ||.||....:         :.|||    :...|.|.|.|...:.:::.:  ||:   :|:
  Fly   905 HLLTLEPWHE---------NQLLVRFEHIMENGEDASYSQPVQFNVKNV--LSAFDVEGIRETTL 958

  Fly  1194 -GNVQLG---RL----------------------SLHTIEATS-LTGTEQ--------KSSRESY 1223
             ||..|.   ||                      |:|.:.|.. :.|.:.        :...||.
  Fly   959 DGNAWLDESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAEKPMLGVKYADEALPAGQLGAESN 1023

  Fly  1224 HIRSLAE--------------------------------ISLEPMELRTF 1241
            .||...|                                |.|.|||:|||
  Fly  1024 RIRRETETRQEKKDEGRSSKSTEGPYNSFKSDSSNQEYIIELSPMEIRTF 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIb	NP_001262614.1	PLN02701	148..1246	CDD:178304	290/1221 (24%)
		GH38N_AMII_GMII_SfManIII_like	167..514	CDD:212120	102/366 (28%)
		Alpha-mann_mid	508..596	CDD:286360	32/88 (36%)
		Glyco_hydro_38C	813..1241	CDD:285047	117/542 (22%)
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	82/304 (27%)
		Alpha-mann_mid	370..445	CDD:214875	31/87 (36%)
		Glyco_hydro_38C	502..957	CDD:285047	129/578 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C64901482
eggNOG	1	0.900				E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0001898
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			P	PTHR11607
RoundUp	0	0.000	Not matched by this tool.
	4	3.930