Protein Alignment obe and Ascc3

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_932124.2
• Gene: Ascc3 / 77987
• MGIID: 1925237
• Length: 2198
• Species: Mus musculus
• Alignment Length: 2225
• Identity: 1113/2225 - (50%)
• Similarity: 1504/2225 - (67%)
• Gaps: 94/2225 - (4%)

  Fly     5 PRLSASLRAKTELEARSRRLNVLRQARTTSAASTTTNSQNK-EEQTIA-----RLLAQMPTEKQP 63
            |||:.:||:.:         ||.:|.......:.....::| .||.:.     :.:.:...||..
Mouse     4 PRLTGALRSFS---------NVTKQDNYNEEVADLKLKRSKLHEQVLDFGLTWKKIVKFLNEKLE 59

  Fly    64 AAKVQ-----LQKLRNLVQECMGYEEQPQVVEHAALFLFWLLLDQRVLLVATTQRLHGMFGQTFD 123
            ..|:|     |:.:....::.:|.:...:.:|..|.|||........:....|:.:...||....
Mouse    60 KNKMQNINEDLKDILQAAKQIVGTDNGREAIESGAAFLFMTFHMTDSVGYMETKAIRQTFGPFPS 124

  Fly   124 RKKTQIHDCVQAIGDLLEDHERSALKRWRQTHHKVPGVGPLWGAHIHVKCTPSEWMDISLLTDLA 188
            ...|   ....|...::....:..|..:.|..........::|.::   ....:..|:....:|
Mouse   125 SSAT---SACNATNRIISHFSQDDLTAFVQMAENPCNDRVVFGKNL---AFSFDMYDLDHFDEL- 182

  Fly   189 PDALLKNRTVN---------KFSMKHTTKAAPVASTSS-----EAAK-LSPELQTLLEISAKLDD 238
            |......:|::         :|...:|.:..||..|:.     |..| |:..|:.:.| :|:::|
Mouse   183 PINGESQKTISLDYKKFLNEQFQEPYTPELKPVEKTNGSLLWCEVEKYLNATLKEMTE-AARVED 246

  Fly   239 EHLIIRVGDILGSQRSSEVLQNELMEILGFDYFELVEKLLMERDKIARQLDQFATRSR----RVM 299
              |...:.|:|.|.:|.:.||:||.|:||.:..:|:||||..|..|   :|:|...|.    :|:
Mouse   247 --LCCTLYDMLASAKSGDELQDELFELLGPEGLDLIEKLLQNRITI---VDRFLNSSSDHKFQVL 306

  Fly   300 EVKQKRMEAAASGGAAERRPTVASAVVVQSAQEKQLSKMQRREEKKLQRIMRSIKDEEAEDDPNC 364
            :...|::....|      :|.....|.:||.|||||.|..|||||::.|     ::::|.:|...
Mouse   307 QDSCKKILGENS------KPNYGCQVTIQSEQEKQLMKQYRREEKRIAR-----REKKAGEDGEV 360

  Fly   365 A----VAVSVQQLRMQHQRKLLEAAQREPLLLSTKAAKAEYKQSSYNQPIHYPYVFDSQLLAKQH 425
            :    :....::||:|.:..||. |:..|:|  .:....|:::      |.||:|:|||..|::.
Mouse   361 SGEGVLPFDPKELRIQREHALLN-ARNAPIL--GRQRDVEFEK------IRYPHVYDSQAQARET 416

  Fly   426 AGFIGGSRITLPDNAQRIDNKQWEEVKIPASEPPPLSVGNKRVQIEELDDVGRLAFANCKELNRI 490
            :.||.|:::.||:..||.:.|.:|||:||..||.|:....|.|.|::||:||:|||...|.||||
Mouse   417 SAFIAGAKMILPEGIQRENTKLYEEVRIPYGEPMPVGFEEKPVYIKDLDEVGQLAFKGMKRLNRI 481

  Fly   491 QSVVFPVAYHSNENMLVCAPTGAGKTNVAMLSIVHTIRCHLEQGVINRDEFKIVYIAPMKALAAE 555
            ||:||..||::|||||:||||||||||:|||:|:|.||.|..||||.::||||||:|||||||||
Mouse   482 QSIVFETAYNTNENMLICAPTGAGKTNIAMLTILHEIRQHFHQGVIKKNEFKIVYVAPMKALAAE 546

  Fly   556 MVDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWDVVTRKGSGDVALISLVELLII 620
            |.:.|||||:.|.|.|:|||||:||:|:|:..||:||||||||||||||..|||||..:|:|||:
Mouse   547 MTNYFSKRLEPLGIVVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVKLLIL 611

  Fly   621 DEVHLLHGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNYIDVAHFLRVNPMKGLFYFDSR 685
            |||||||.:||||:|::||||||.|||:||||||:|||||||||:|||.||.|||..||||||.|
Mouse   612 DEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFYFDGR 676

  Fly   686 FRPVPLDTNFVGIKSVKQLQQIADMDQCCYQKCVEMVQEGHQIMVFVHARNATVRTANVIRELAQ 750
            ||||||...|:||||..::||:.:||:.||:..::.|:.|||:||||||||||||||..:.|.|:
Mouse   677 FRPVPLGQTFLGIKSTNKMQQLNNMDEVCYESVLKQVKAGHQVMVFVHARNATVRTAMSLIERAK 741

  Fly   751 QNNTSALFLPKDSAAHGLATRSIQRSRNKQLVELFSCGLAMHHAGMLRADRQMVEKYFVEGHISV 815
            .:...:.|||.:...:|.|.:.:|:|||||:.||||.|.::|||||||.||.:||..|..|||.|
Mouse   742 NSGQISCFLPTEGPEYGHALKQVQKSRNKQVRELFSDGFSIHHAGMLRQDRNLVENLFSNGHIKV 806

  Fly   816 LVCTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLGILDVLQIFGRAGRPQFDKSGVGTIITSY 880
            ||||||||||||||||||:|:||.||.||.|||||||||||:|||||||||||||.|.|.|||::
Mouse   807 LVCTATLAWGVNLPAHAVVIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTH 871

  Fly   881 DKLNHYLSLLTNQFPIESNFVNCLADNLNAEIGLGTITNVDEAIEWLSYTYLFVRMRINPHVYGI 945
            |||:|||||||.|.||||.|:..|||||||||.|||:|||:||:.|:|||||:||||.||..|||
Mouse   872 DKLSHYLSLLTQQNPIESQFLESLADNLNAEIALGTVTNVEEAVRWMSYTYLYVRMRANPLAYGI 936

  Fly   946 EYSELEKDPTLEARRRALIMSAAMSLDKARMMRFNQRTMDMNITDLGRTASYFYIKYDTVETFNE 1010
            .:...:.||||...|..|::.....||||:|:||.:||...:.||||||||:|||||:|:|||||
Mouse   937 SHKAYQIDPTLRKHREQLLIEVGQKLDKAKMIRFEERTGYFSSTDLGRTASHFYIKYNTIETFNE 1001

  Fly  1011 LMKPFMTQAEILAMISQAQEFQQLKVRDDEMEELDELKNAYCKIKPYGGSENVHGKVNILIQTYL 1075
            |.....|:.:|.|::|:|:||.|:|||::|:||||.|.|.:|::...||.||.:||:|||:|||:
Mouse  1002 LFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDALLNNFCELSAPGGVENSYGKINILLQTYI 1066

  Fly  1076 SNGYVKSFSLSSDMSYITTNIGRISRALFSIVLRQNNAVLSGNMLQLCKMFERRQWDFDCHLKQF 1140
            |.|.:.||||.||.:|:..|..||.||||.|.||:....::..:|.|.|:.::|.|.:...|:||
Mouse  1067 SRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQF 1131

  Fly  1141 PTINAETIDKLERRGLSVYRLRDMEHRELKEWLRSNTYADLVIRSAHELPLLEVEASLQPITRTV 1205
            ..:....:.:||.:.|:|.:|:||...|:...|........|.:..|::|.:.:|||:|||||||
Mouse  1132 SVLPPHILTRLEEKNLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVTMEASIQPITRTV 1196

  Fly  1206 LRIKVDIWPSFTWNDRVHGKTCQSFWLWIEDPESNYIYHSELFQVTRKLVMSGQSQQLVMTIPLK 1270
            ||:.::|.|.|:|||:|||...:.:|:|:|||.:::|||||.|...:|.|::.::|.||.|||:.
Mouse  1197 LRVSLNIHPDFSWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVINKEAQLLVFTIPIF 1261

  Fly  1271 EPLPPQYYIRVSSDNWLGSTTCIPLSFQHLVLPEHHPPLTELLPLRPLPVSCLKNVVYESLYKFT 1335
            ||||.|||||..||.|||:.....::||||:|||.|||.||||.|:|||::.|....||:||.|:
Mouse  1262 EPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFS 1326

  Fly  1336 HFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNPKCKVVYIAPLKALVKERIA 1400
            ||||:||||||.|||||.|||||||||||||:.||:||||..|:.|..|.||||||||||:||:.
Mouse  1327 HFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMD 1391

  Fly  1401 DWEQRFQRSSLGLKVVELTGDVTPDIQAIRESQLIVTTPEKWDGISRSWQTREYVQHVSLIVIDE 1465
            ||:.|.: ..||.||:|||||||||:::|.::.|||||||||||:|||||.|.|||.|::::|||
Mouse  1392 DWKIRIE-EKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRSYVQQVNILIIDE 1455

  Fly  1466 IHLLGEDRGPVIEVIVSRTNFISSHTGRAIRIVGLSTALANAQDLANWLGINKMGLYNFKPSVRP 1530
            ||||||:||||:||||||||||||||.:.:||||||||||||:|||:||.|.:|||:||:|||||
Mouse  1456 IHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRP 1520

  Fly  1531 VPLQVHINGFPGKHYCPRMATMNRPTFQAIRTYSPCEPTIVFVSSRRQTRLTALDLITFVAGESN 1595
            |||:|||.||||:|||||||:||:|.|||||::||.:|.::|||||||||||||:||.|:|.|.:
Mouse  1521 VPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEED 1585

  Fly  1596 PKQFLHIPEDEIELILQNIREQNLKFCLAFGIGLHHAGLQEQDRKCVEELFLNRKIQILVATATL 1660
            |||:|::.|.|::.|:..:|:.|||..||||||:|||||.|:|||.|||||:|.|:|:|:||:||
Mouse  1586 PKQWLNMDEQEMDNIIGTVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTL 1650

  Fly  1661 AWGVNLPAHLVVIKGTEYFDGKVKKYVDMPITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYK 1725
            |||||.|||||:||||||:|||.::|||.||||||||||||||||||::|.||:||||.||:|||
Mouse  1651 AWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYK 1715

  Fly  1726 KFLYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAALDYLTWTYFFRRLLRNPSYYQLQDIEPEN 1790
            ||||:||||||||||||.:|:||||..||:.|||.|:||:|||||||||:.|||||.|.|:..::
Mouse  1716 KFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDAMDYITWTYFFRRLIMNPSYYSLGDVSQDS 1780

  Fly  1791 VNNFMSNLVERVVYELSAAACL-VERDGCLI-PTFLGRISSYYYLSYRTMKHFLEDLQPGMNTKK 1853
            :|.|:|:|:.:.:.||..:.|: |..|...| |...|||:|||||.::|:|.|.:.|:|..:|::
Mouse  1781 INKFLSHLIGQSLVELELSHCIEVGEDNRTIEPLTCGRIASYYYLKHKTVKMFKDRLKPECSTEE 1845

  Fly  1854 VLLAIADSYEFDQLPVRHNEDKHNEEMAEVSRFRPPSSSWDSSYTKTFLLLQAHFARQSLPNSDY 1918
            :|..::|:.|:..||||||||..|.|:|:.........|:||.:||..||||||.:|..||..||
Mouse  1846 LLSILSDAEEYTDLPVRHNEDHTNNELAKCLPIELNPHSFDSPHTKAHLLLQAHLSRAMLPCPDY 1910

  Fly  1919 LTDTKSALDNATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQARWFDGSEFLTLPGVNEDNLDA 1983
            .||||:.||.|.||.|||:|..|.:|||.|.|.:..|:|.|||.||...|..||:|.:.:.:|..
Mouse  1911 DTDTKTVLDQALRVCQAMLDVAASQGWLVTVLNITHLIQMVIQGRWLKDSSLLTIPNIEQHHLHL 1975

  Fly  1984 F------LNIPHDD--YDYLTLPVLKELCKQEYEVLAKPLRDAFEEHEIEKMYKVIQDLPEIAIQ 2040
            |      :...|..  .....||.|...|:.:..|.:..:....:..:.::.:..:..||.|.:.
Mouse  1976 FRKWKPPVKSSHAKCRTSIECLPELIHACEGKDHVFSSMVEKELQPAKTKQAWNFLSRLPVINVG 2040

  Fly  2041 IFVEGRHMENEYAKRPLSLSD---DTRGE--WMSLHANEDYVLIVNLQRLNVSGQRRGGGQSYTV 2100
            |.|:|...:.......||:|.   |.|.|  |:.|||:::|||.|:|||::. |..:|..:::.|
Mouse  2041 ISVKGSWDDLVEGHNELSISTLTADKRDENKWIKLHADQEYVLQVSLQRVHF-GLPKGKHENHAV 2104

  Fly  2101 HCPKYPKPKNEAWFLTLGSQANDELLAMKRVSIRGQRCTNRISFQATPRLGRLQLTLYLMSDCLM 2165
             .|::||.|:|.|||.||.....||:|:|||..........|||......||...||||||||.:
Mouse  2105 -TPRFPKLKDEGWFLILGEVDKRELMAVKRVGFVRTHHDASISFFTPETPGRYIFTLYLMSDCYL 2168

  Fly  2166 GFDQQYDLQFEIIDA 2180
            |.|||||:...:|.|
Mouse  2169 GLDQQYDIYLNVIKA 2183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	17/36 (47%)
		BRR2	485..1025	CDD:440817	356/539 (66%)
		DEXHc_ASCC3_1	486..683	CDD:350778	143/196 (73%)
		SEC63	985..1298	CDD:214744	144/312 (46%)
		BRR2	1334..1859	CDD:440817	351/526 (67%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	136/188 (72%)
		SEC63	1818..2176	CDD:214744	145/371 (39%)
Ascc3	NP_932124.2	BRR2	461..1016	CDD:440817	364/554 (66%)
		DEXHc_ASCC3_1	477..674	CDD:350778	143/196 (73%)
		DEVH box	612..615		2/2 (100%)
		Sec63	979..1287	CDD:460740	144/307 (47%)
		DEXHc_ASCC3_2	1327..1515	CDD:350780	136/188 (72%)
		BRR2	1328..1850	CDD:440817	349/522 (67%)
		DEIH box	1454..1457		2/2 (100%)
		SEC63	1810..2179	CDD:214744	145/370 (39%)