Protein Alignment obe and hfm1

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: XP_031756056.1
• Gene: hfm1 / 779837
• XenbaseID: XB-GENE-5894880
• Length: 1433
• Species: Xenopus tropicalis
• Alignment Length: 1097
• Identity: 292/1097 - (26%)
• Similarity: 466/1097 - (42%)
• Gaps: 280/1097 - (25%)

  Fly  1197 SLQPITRTVLRIKVDIWPSFTWNDRVHGK-----TCQSFWLWIEDPESNYIYHSELFQVTRKLVM 1256
            ||.|:|.|...:.       .:...:.||     ..:...|.:|:..||::...|    .:|..|
 Frog   123 SLSPVTDTEENMS-------AFKKSLFGKYDCSLNSEDQCLIVENGSSNFVTSKE----AQKEAM 176

  Fly  1257 SGQ-----SQQLVM-----TIPLKEPLPPQYYIRVSSDNWLGSTTCIPLSFQHLVLPEHHPPLTE 1311
            ...     .||:..     |:..|:.|..:.:...:|.|.......     |:.::    .|:||
 Frog   177 KADFDICPPQQMAFDLFNETVVQKDMLNKEKFSHSASSNISNKDDA-----QYGIV----TPVTE 232

  Fly  1312 LLPLRPLPVSCLKNVVYESLYK-FTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFR 1375
             :|.:           :.:::| |.:||.||::....|.::|.|.:|.||||||||::.|:||.|
 Frog   233 -IPKQ-----------FRTVFKEFPYFNYIQSKALEHLLYSDRNFVLCAPTGSGKTVIFELAIIR 285

  Fly  1376 ALNQNP----KCKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELTGDV-TPDIQAIRESQLI 1435
            .|.|.|    ..|:||:||:|||..:|..||:.:|  ..:||...|||||. ..|:..|:.:.:|
 Frog   286 LLMQVPMPWTNVKIVYMAPIKALCGQRYDDWKAKF--GPVGLNCKELTGDTEMDDLFEIQHAHII 348

  Fly  1436 VTTPEKWDGISRSWQTREYVQHVSLIVIDEIHLLGED-RGPVIEVIVSR--TNFISSHTGR---- 1493
            :|||||||.::|.|:....||.|.|.:|||:|:|.|: ||..:||:|||  |.:..||...
 Frog   349 MTTPEKWDSMTRKWKDNTLVQLVRLFLIDEVHILKEENRGATLEVVVSRMKTIYSLSHLSEDRKA 413

  Fly  1494 --AIRIVGLSTALANAQDLANWLG-INKMGL-YNFKPSVRPVPLQVHINGFPGKHYCPRM----- 1549
              .:|.|.:|..:.|.:|:|:||. .|..|: .....|.|||.|:..:.|||    |...
 Frog   414 FIPMRFVAVSATIPNVEDIADWLSDENSPGVCMKMDESSRPVKLRKVVLGFP----CSTKQSEFK 474

  Fly  1550 --ATMNRPTFQAIRTYSPCEPTIVFVSSRRQTRLTALDLITFVAGESNPKQFLHIP-EDEIELIL 1611
              .|:|......|:|||...||:||.|:|:..: .|..::|     .:.|..:.|. :..::...
 Frog   475 FDLTLNYKIANIIQTYSDGRPTLVFCSTRKGVQ-QAASILT-----KDAKFVMSIEHKQRLQKCA 533

  Fly  1612 QNIREQNLKFCLAFGIGLHHAGLQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGT 1676
            .:|::..|:..|.:|:|.||||:...|||.:|..||...:.:|..|:|||.|||||||||::|.|
 Frog   534 NSIKDSKLRDVLQYGVGYHHAGVDISDRKVIENSFLIGDLPVLFTTSTLAMGVNLPAHLVIVKST 598

  Fly  1677 -EYFDGKVKKYVDMPITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLG 1740
             .|..|..::|.:   ||:|||:|||||||||:...||::.....|..|...|.....:||||..
 Frog   599 MHYVSGMFQEYSE---TDILQMIGRAGRPQFDSTATAVIMTRLSTKEKYVHMLDGADTIESSLHK 660

  Fly  1741 VLPEHINAEIVAGTVQSKQAALDYLTWTYFFRRLLRNPSYY-------------QLQDIEPENVN 1792
            .|.||:||||...|:...:.||:::..|:.:.|.|:||:||             :||::..:|:|
 Frog   661 HLVEHLNAEIALHTITDVKVALEWIRSTFLYIRALKNPAYYGFSEGLDKIGIEAKLQELCLKNLN 725

  Fly  1793 NFMS----NLVERVVYELSAAACLVERDGCLIPTFLGRISSYYYLSYRTMK--HFLEDLQPGMNT 1851
            :..|    .:.|.:.::               ||..|::.:.||:::.|.|  |.:.    |..|
 Frog   726 DLSSLGLIKMDEEINFK---------------PTETGKLMALYYIAFNTAKLFHTIR----GTET 771

  Fly  1852 KKVLLAIADS-YEFDQLPVRHNE----DKHNEEMAEVSRFRPPSSSWDSSYTKTFLLLQAHFARQ 1911
            ...|:::..| .||..:.:|.||    :..|::...|:...|......:...|...|:|||....
 Frog   772 LAELVSLISSCSEFSDVQLRANERRVLNTLNKDKNRVTIRYPMEGKIKTKEMKVNCLIQAHLGCI 836

  Fly  1912 SLPNSDYLTDTKSALDNATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQARWFDGSEFLTLPGV 1976
            .:.:.....|......:.||:.:.:                               ||||.|
 Frog   837 LVQDFSLTQDISKIFRHGTRLAKCL-------------------------------SEFLAL--- 867

  Fly  1977 NEDNLDAFLNIPHDDYDYLTLPVLKELCKQEYEVLAKPLRDAFEEH------EIEKM-------- 2027
            .|:...||||.                     .:|.|..:....|:      ::||:
 Frog   868 QENKFSAFLNA---------------------LILTKCFKSKLWENSSHISKQLEKIGVTLANAM 911

  Fly  2028 -------YKVIQDLPEIAIQIFVE-----GRHMENEYAKRP--------LSLSDDTRGEWMSLHA 2072
                   :|.|:|.....:::.|.     |..::...|..|        |:....|..|.:..
 Frog   912 VNAGLTTFKKIEDTNARELELIVNRHPPFGNQIKESVAHLPKYEIKFQQLAKYRATTAEVVLT-- 974

  Fly  2073 NEDYVLIVNLQRLNVSGQRRGGGQSYTVHCPKYPKPKNEAWFLTLGSQANDEL------------ 2125
                ||:.|.::|.   ::|....|:.|             .|.:|...|..:
 Frog   975 ----VLLTNFKQLQ---KKRTAPDSHFV-------------MLVIGDDDNQAIFKQKIMDSSLFK 1019

  Fly  2126 -------LAMKRVSIRGQRCTNRISFQATPRLGRLQLTLYLMSD-------CLMGFD 2168
                   :.:||.|.....|.|.||.:            |:..|       |.:|.|
 Frog  1020 TGSWTRKIEIKRASKSTNVCLNLISSE------------YVGLDIQQSFNICYLGSD 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309
		BRR2	485..1025	CDD:440817
		DEXHc_ASCC3_1	486..683	CDD:350778
		SEC63	985..1298	CDD:214744	21/115 (18%)
		BRR2	1334..1859	CDD:440817	201/568 (35%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	84/204 (41%)
		SEC63	1818..2176	CDD:214744	75/418 (18%)
hfm1	XP_031756056.1	BRR2	230..764	CDD:440817	201/575 (35%)
		DEXHc_HFM1	246..454	CDD:350781	85/209 (41%)
		Sec63	743..1057	CDD:460740	72/406 (18%)