Protein Alignment obe and Hfm1

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_001399493.1
• Gene: Hfm1 / 690161
• RGDID: 1584010
• Length: 1474
• Species: Rattus norvegicus
• Alignment Length: 845
• Identity: 265/845 - (31%)
• Similarity: 418/845 - (49%)
• Gaps: 131/845 - (15%)

  Fly  1328 YESLYK-FTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNP----KCKVVY 1387
            :.|::| |.:||.||::.|..|.:||.|.::.||||||||:|.|:||.|.|.:.|    ..||||
  Rat   270 FRSVFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEAPLPWLNMKVVY 334

  Fly  1388 IAPLKALVKERIADWEQRFQRSSLGLKVVELTGD-VTPDIQAIRESQLIVTTPEKWDGISRSWQT 1451
            :||:|||..:|..||:::|  ..:||...||||| |..|:..|:.:.:|:|||||||.::|.|:.
  Rat   335 MAPIKALCSQRFDDWKEKF--GPIGLTCKELTGDTVMDDLFEIQHANIIMTTPEKWDSMTRKWRD 397

  Fly  1452 REYVQHVSLIVIDEIHLL-GEDRGPVIEVIVSRTNFISS-------HTGRAIRIVGLSTALANAQ 1508
            ..::|.|.|.:|||:|:: .|:|||.:||:|||...:.|       .:...:|.|.:|..:.||:
  Rat   398 NSFIQLVRLFLIDEVHVIKDENRGPTLEVVVSRMKTVQSLSKTLENASPAPVRFVAVSATIPNAE 462

  Fly  1509 DLANWLGINKMGLYNFKPSV--------RPVPLQVHINGFPGKHYCPRM---ATMNRPTFQAIRT 1562
            |:|.||...:      :|:|        |||.||..:.|||........   ..:|...:..|||
  Rat   463 DIAEWLSDGE------RPAVCLKMDESHRPVKLQKVVLGFPSSSNQTEFKFDLALNYKVYSVIRT 521

  Fly  1563 YSPCEPTIVFVSSRRQTRLTALDLITFVAGESNPKQFLHIPEDEIEL--ILQNIREQNLKFCLAF 1625
            ||..:||:||.::|:..:..|..|:       ...:|:...|.::.|  ...:||:..||..|.:
  Rat   522 YSDQKPTLVFCATRKGVQQAASVLV-------KDAKFIITVEQKLRLQKSAYSIRDSKLKDTLVY 579

  Fly  1626 GIGLHHAGLQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGT-EYFDGKVKKYVDM 1689
            |:|.||||::..|||.|||||.:..:.:|..|:|||.||||||||||||.| .|..|..::|.:
  Rat   580 GVGYHHAGMELSDRKLVEELFTSGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYTGGAFEEYSE- 643

  Fly  1690 PITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGT 1754
              ||:|||:|||||||||....||::.....:..|.:.|.....|||||...|.||:|||||..|
  Rat   644 --TDILQMIGRAGRPQFDTTATAVIMTRLSTREKYVQMLACNDTVESSLHRHLIEHLNAEIVLHT 706

  Fly  1755 VQSKQAALDYLTWTYFFRRLLRNPSYYQ-LQDIEPENVNNFMSNLVERVVYELSAAACL-VERDG 1817
            :.....|||::..|..:.|.|:|||:|. :..:..:.:...:..|..:.:.:||:...: ::.|.
  Rat   707 ITDVSIALDWIRSTLLYIRALKNPSHYGFISGLNKDGIEAKLQELCLKNLKDLSSLDLIKMDEDL 771

  Fly  1818 CLIPTFLGRISSYYYLSYRTMKHF--------LEDLQPGMNTKKVLLAIADSYEFDQLPVRHNED 1874
            ....|..||:.::||:::.|:|.|        |.||         :..|:...||..:.:|.:|.
  Rat   772 NFRSTEAGRLMAWYYITFETVKKFCAISGKETLSDL---------ISMISSCSEFLDVQLRISEK 827

  Fly  1875 KH----NEEMAEVSRFRPPSSSWDSSYTKTFLLLQAHFARQSLPNSDY-LT-DTKSALDNATRVM 1933
            :.    |::...::...|......:...|...|:||...  .:|..|: || ||.....|.:|:.
  Rat   828 RTLNTLNKDPNRITIRFPMEGRIKTREMKVNCLIQAQLG--CIPIQDFALTQDTSKIFRNGSRIA 890

  Fly  1934 QAMVDYTAERGWLSTTLVVQQ-----LMQSVIQARWF-----DGSEFLTLP----GVNEDN---- 1980
            :          |||..:..|:     |:.|||.|:.|     :.|:.::..    |::..|
  Rat   891 K----------WLSDFVTAQEQKFAVLLNSVILAKCFKCKLWENSQHVSKQLDKIGISLSNTMVN 945

  Fly  1981 --LDAFLNIPHDDYDYLTLPVLKELCKQEYEVLAKPLRDAF-----EEHEIEKMYKVIQDLPEIA 2038
              |.:|..|...:...|      ||....:......:::|.     .|.|.|::.:......||.
  Rat   946 AGLTSFKKIEEANAREL------ELILNRHPPFGTQIKEAVMYLPKYELEAEQIARYSDTKAEIL 1004

  Fly  2039 IQIFVEGRHMENEYAKRPLS-------LSDDTRGEWMSLHANEDYVLI--------VNLQRLNVS 2088
            :.|.:  |:.|....||...       :..|...:.:..|...|.||:        ::::|..:|
  Rat  1005 VTIIL--RNFEQLQTKRTAPDFHYATLIIGDADNQVVCKHKIMDSVLLKSGNWVKKIDVKRALIS 1067

  Fly  2089  2088
              Rat  1068  1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309
		BRR2	485..1025	CDD:440817
		DEXHc_ASCC3_1	486..683	CDD:350778
		SEC63	985..1298	CDD:214744
		BRR2	1334..1859	CDD:440817	207/561 (37%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	83/201 (41%)
		SEC63	1818..2176	CDD:214744	67/325 (21%)
Hfm1	NP_001399493.1	BRR2	263..795	CDD:440817	205/542 (38%)
		DEXHc_HFM1	279..486	CDD:350781	85/214 (40%)
		Sec63	775..1088	CDD:460740	67/322 (21%)