Protein Alignment obe and hfm1

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_001429764.1
• Gene: hfm1 / 557052
• ZFINID: ZDB-GENE-061207-43
• Length: 1509
• Species: Danio rerio
• Alignment Length: 1119
• Identity: 293/1119 - (26%)
• Similarity: 478/1119 - (42%)
• Gaps: 242/1119 - (21%)

  Fly  1190 PLLEVEASLQPITRTVLRIKVDIWPSFTWNDR------------------VHGKTCQSF-----W 1231
            |.|....|.|.|.|......     ||:::.|                  :.|:|.||.     .
Zfish    40 PSLSQIPSTQDIQREAAHAS-----SFSFSQRSKTFLPPAQKPIHNPTEGIQGQTVQSHELEEPG 99

  Fly  1232 LWIEDPESN---------------------YIYHSELFQV-TRKLVMSGQ---SQQLVMT----- 1266
            ||..:|.|.                     ..:.:.|||. ||:...:|:   |.|.:.|
Zfish   100 LWSHEPSSTGEQAVFRMGFAETRPLPTASAPPFKTRLFQASTRRTSGNGEDGISNQTLSTTNDTA 164

  Fly  1267 ----IPLKEPLPPQYYIRVSSDNWLG----STTC-IPLSFQ-HLVL-PEHHPPLTELLPLRPLPV 1320
                .|.:...|...:...:...::|    ...| :|.|.. ||.| |......:|...||.:..
Zfish   165 FQSQAPRRTSGPQAAHAVAACSPFIGLAQTEEKCDVPSSHSLHLGLKPAEFKGSSEKGTLRSVSE 229

  Fly  1321 SCLKNVVYESLYK-FTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNPK-- 1382
            ...|   :.|::| |.:||.:|:|....:.:::.|.:..||||||||::.|:||.|.|.:..:
Zfish   230 IPAK---FRSVFKDFPYFNYVQSQALDDVLYSNKNFVACAPTGSGKTVLFELAIVRLLIEASEPW 291

  Fly  1383 --CKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELTGDV-TPDIQAIRESQLIVTTPEKWDG 1444
              .:.||:||:|||..::..:|:|:|  ..||||..|||||. ..|...|:::.||.||.||||.
Zfish   292 HNVRAVYMAPIKALCSQQYDNWKQKF--GPLGLKCKELTGDTEIDDFFEIQDAHLIFTTAEKWDS 354

  Fly  1445 ISRSWQTREYVQHVSLIVIDEIHLL-GEDRGPVIEVIVSR-------TNFISSHTGRAIRIVGLS 1501
            ::|.|:....:..:.|.::||:|:: .:.||..:||:|||       ...|:..:..::|.|.:|
Zfish   355 MTRRWKDNCLLTSIRLFLVDEVHVVKDKTRGATLEVVVSRMKTMHFYRQAINPESKASVRFVAVS 419

  Fly  1502 TALANAQDLANWLGINKMG---LYNFKPSVRPVPLQVHINGFP---GKHYCPRMATMNRPTFQAI 1560
            ..:.|.||::.||. ::.|   ......|.|||.|:..:.|||   .::......::|......|
Zfish   420 ATIPNIQDVSEWLS-DESGPATCLEMDESHRPVKLRKVVLGFPCGSNQNEFKFDLSLNYKLANII 483

  Fly  1561 RTYSPCEPTIVFVSSRRQTRLTALDLITFVAGESNPKQFLHIPEDEIELI--LQNIREQNLKFCL 1623
            :|||..:||:||.|:|:..:.:|..|       :...:|:...:.:..|:  ..::.:..|:...
Zfish   484 QTYSDQKPTLVFCSTRKGVQQSASVL-------AKDARFIMSIDHKQRLVKYANSLLDAKLRDLF 541

  Fly  1624 AFGIGLHHAGLQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGT-EYFDGKVKKYV 1687
            .:|||.||||:...|||..|..|....:.:|..|:|||.|||:||||||||.| .|..|..::|.
Zfish   542 VYGIGYHHAGMDVSDRKITENAFTVGDLPVLFTTSTLAMGVNMPAHLVVIKSTMHYVGGACEEYS 606

  Fly  1688 DMPITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVA 1752
            :   .|:|||:|||||||||....||::...:.|:.|..||.....:||||...|.||:|||||.
Zfish   607 E---ADLLQMIGRAGRPQFDTTATAVIMTRPQTKDKYMHFLSGLDCIESSLHTNLVEHLNAEIVL 668

  Fly  1753 GTVQSKQAALDYLTWTYFFRRLLRNPSYY-------------QLQDIEPENVNNFMS-NLVERVV 1803
            .|:.....|||::..|:.:.|.|:||.:|             :||::..:|:|:..| ||:
Zfish   669 HTISDVNMALDWIRSTFLYIRALKNPKHYGFPPEVDKCGIETKLQELCLKNLNSLASFNLI---- 729

  Fly  1804 YELSAAACLVERDGCLIPTFLGRISSYYYLSYRTMKHFLEDLQPGMNTKKVLL-AIADSYEFDQL 1867
                    .::.|..:.||..|::.:.|.:::.|:|.|  .:..|..|...|: .|:.:.||..:
Zfish   730 --------TMDEDINIKPTETGKLMARYCVAFDTVKQF--SMVTGTETLPELIEMISKAKEFSDM 784

  Fly  1868 PVRHNEDK-----HNEEMAEVSRFRPPSSSWDSSYTKTFLLLQAHFARQSLPNSDYLTDTKSALD 1927
            .:|.||.|     :.::.....|| |......|:..|...|:||......:.....:.||.....
Zfish   785 QLRVNERKTLNTLNKDKNRTTIRF-PIEGKIKSNDMKVNCLIQAQLGCIPIQEFGLIQDTGKIFR 848

  Fly  1928 NATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQARWFDGSEFLTLPGVNEDNLDAFLNIPHDDY 1992
            ||.||.:.:.::.....  .:....|  :.::|.|:.|....:...|.::
Zfish   849 NAVRVSRYLTEFLCHHS--KSNFAAQ--LNALILAKCFRAKLWENSPYIS--------------- 894

  Fly  1993 DYLTLPVLKELCKQEYEVLAKPLRDAFEEHEIEKMYKVIQDLPEIAIQIFVEGRHMENEYAKRPL 2057
                         ::.|.:...|..|.....:....|:.|..|. .:::.| .||..
Zfish   895 -------------KQLERIGLSLATALVNAGLTTFSKIEQTSPR-ELELIV-NRHPP-------- 936

  Fly  2058 SLSDDTRGEWMSLHANEDYVLIVNLQRLNVSGQRRGGGQSYTVHCPKYPKPKNEAWFLTLGSQAN 2122
                         ..|:....|..|.|..||.::          .|:|.....|..|..  :..|
Zfish   937 -------------FGNQIKEAISKLPRCEVSLEQ----------IPRYSPSTAEIVFTV--NMNN 976

  Fly  2123 DELLAMKRVS--------IRGQRCTNRISFQ---------------------ATPRLGRLQLTLY 2158
            .:.||:||.:        |.|. |.|::.||                     .:|: |. :|:::
Zfish   977 FKELALKRTAPDHHYVTLIVGD-CDNKVVFQQKISDTLLLKSGSWSKRIEVTRSPK-GE-ELSIH 1038

  Fly  2159 LMSDCLMGFDQQYD 2172
            |:|...:|.|.|.|
Zfish  1039 LISSEYVGLDIQQD 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309
		BRR2	485..1025	CDD:440817
		DEXHc_ASCC3_1	486..683	CDD:350778
		SEC63	985..1298	CDD:214744	32/169 (19%)
		BRR2	1334..1859	CDD:440817	186/561 (33%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	70/204 (34%)
		SEC63	1818..2176	CDD:214744	75/390 (19%)
hfm1	NP_001429764.1	None