Protein Alignment obe and Snrnp200

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_796188.2
• Gene: Snrnp200 / 320632
• MGIID: 2444401
• Length: 2136
• Species: Mus musculus
• Alignment Length: 2250
• Identity: 839/2250 - (37%)
• Similarity: 1298/2250 - (57%)
• Gaps: 219/2250 - (9%)

  Fly    11 LRAKTELEARSRR-------LNVLRQARTTSAA--STTTNSQNKEEQTIARLLAQMPTEKQPAAK 66
            |:|...|..|:||       |:::.:...|...  :..|..|.:||:...|       .|:...:
Mouse    21 LQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQEERRAKR-------RKRDEDR 78

  Fly    67 VQLQKLRNL------VQECMGYEEQPQVVE----HAAL--FLFWLLLDQ----------RVLLVA 109
            ..:.|::..      :.|.:|...:|:..|    :..|  |:...|.||          .||.|.
Mouse    79 HDMNKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVL 143

  Fly   110 TTQRLHG---------MFGQTFDRKKTQIHDCVQAIGDLLEDHERSALKRWRQTHHKVPGVGPLW 165
            ..::|..         :.|||.|   |:.|..|. :|..:.|:...     ::..:....:...:
Mouse   144 KNEKLRDKERRREIDLLLGQTDD---TRYHVLVN-LGKKITDYGGD-----KEIQNMDDNIDETY 199

  Fly   166 GAHIHVKCTPSEWMDISLLTDLAPDALLKNRTVNKFSMKHTTKAAPVAS---TSSEAAKLSPE-- 225
            |.::..:....|. |..:..::..:|...:...::..::.|..|..|||   .||:...|.|.
Mouse   200 GVNVQFESDEEEG-DEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDI 263

  Fly   226 ----LQTLLE-------ISAKLDDEHLIIRVGDILGSQRSSEVLQNELMEILGFDYFELVEKLLM 279
                ||..|.       :|.|..||.|     :||.:.......:|:|:.:|||:.|:.::.|
Mouse   264 DAFWLQRQLSRFYDDAIVSQKKADEVL-----EILKTASDDRECENQLVLLLGFNTFDFIKVL-- 321

  Fly   280 ERDKIARQLDQFATRSRRVMEVKQKRMEAAASGGAAERRPTVASAVVVQSAQEKQLSK----MQR 340
                          |..|:|.:....:.:|.|....||       :|.:...:.:|||    :..
Mouse   322 --------------RQHRMMILYCTLLASAQSEPEKER-------IVGKMEADPELSKFLYQLHE 365

  Fly   341 REEKKLQRIMRSIKDEEAEDDPNCAVAVSVQQLRMQHQRKLLEAAQREPLLLSTKAAKAEYKQSS 405
            .|::.|.|..||.::.             |:|.||....:.::..|....|...:....|
Mouse   366 TEKEDLIREERSRRER-------------VRQSRMDTDLETMDLDQGGEALAPRQVLDLE----- 412

  Fly   406 YNQPIHYPYVFDSQLLAKQHAGFIGGSRITLPDNAQRIDNKQWEEVKIPASEPPPLSVGNKRVQI 470
                         .|:..|.:.|:...|..|||.:.|...|.:|||.:||.:|.|.....:.:.:
Mouse   413 -------------DLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPV 464

  Fly   471 EELDDVGRLAFANCKELNRIQSVVFPVAYHSNENMLVCAPTGAGKTNVAMLSIVHTIRCHLE-QG 534
            |:|....:..|...|.||||||.::..|..::||:|:||||||||||||::.::..|..|:. .|
Mouse   465 EKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDG 529

  Fly   535 VINRDEFKIVYIAPMKALAAEMVDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWD 599
            .||.|:|||:|||||::|..|||.:|.|||.:..|.|.|||||.||.|.|::||||:|.||||||
Mouse   530 TINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWD 594

  Fly   600 VVTRKGSGDVALISLVELLIIDEVHLLHGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNY 664
            ::|||| |:.....||.|:::||:||||.:||||:||||||.:|.:|.:|..:|::|||||||||
Mouse   595 IITRKG-GERTYTQLVRLIVLDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNY 658

  Fly   665 IDVAHFLRVNPMKGLFYFDSRFRPVPLDTNFVGIKSVKQLQQIADMDQCCYQKCVEMVQEGHQIM 729
            .|||.||||:|.|||||||:.||||||:..:|||...|.:::...|::..|:|.:|...: :|::
Mouse   659 EDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGK-NQVL 722

  Fly   730 VFVHARNATVRTANVIRELAQQNNTSALFLPKDSAAHGLATRSIQRSRNKQLVELFSCGLAMHHA 794
            ||||:|..|.:||..||::..:.:|..|||.:.||:..:.....::.:|.:|.:|...|.|:|||
Mouse   723 VFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHA 787

  Fly   795 GMLRADRQMVEKYFVEGHISVLVCTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLGILDVLQI 859
            ||.|.||.:||..|.:.||.|||.|||||||||||||.|||:||.:|..:.|.:.:||.||:||:
Mouse   788 GMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQM 852

  Fly   860 FGRAGRPQFDKSGVGTIITSYDKLNHYLSLLTNQFPIESNFVNCLADNLNAEIGLGTITNVDEAI 924
            .|||||||:|..|.|.:|||:.:|.:|||||..|.||||..|:.|.|.|||||.||.:.|..:|:
Mouse   853 LGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAV 917

  Fly   925 EWLSYTYLFVRMRINPHVYGIEYSELEKDPTLEARRRALIMSAAMSLDKARMMRFNQRTMDMNIT 989
            .||.|.||::||..:|.:|||.:.:|:.||.|:.||..|:.:||:.|||..:::::::|.:..:|
Mouse   918 NWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVT 982

  Fly   990 DLGRTASYFYIKYDTVETFNELMKPFMTQAEILAMISQAQEFQQLKVRDDEMEELDELKNAYCKI 1054
            :|||.||::||..|||:|:|:|:||.:::.|:..:.|.:.||:.:.||::|..||.:|....
Mouse   983 ELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERV--- 1044

  Fly  1055 KPYGGSENVH---GKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIVLRQNNAVLS 1116
             |....|::.   .|:|:|:|.::|...::.|:|.:||.|:|.:.||:.||:|.|||.:..|.|:
Mouse  1045 -PIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLNRGWAQLT 1108

  Fly  1117 GNMLQLCKMFERRQWDFDCHLKQFPTINAETIDKLERRGLSVYRLRDMEHRELKEWLRSNTYADL 1181
            ...|.||||.::|.|...|.|:||..:..|.:.|:|::.....||.|:.|.|:.|.:|.......
Mouse  1109 DKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKMGKT 1173

  Fly  1182 VIRSAHELPLLEVEASLQPITRTVLRIKVDIWPSFTWNDRVHGKTCQSFWLWIEDPESNYIYHSE 1246
            :.:..|..|.||:...||||||:.|::::.|.|.|.|:::|||.: ::||:.:||.:|..|.|.|
Mouse  1174 IHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSS-EAFWILVEDVDSEVILHHE 1237

  Fly  1247 LFQVTRKLVMSGQSQQLV-MTIPLKEPLPPQYYIRVSSDNWLGSTTCIPLSFQHLVLPEHHPPLT 1310
            .|.:..|.   .|.:.|: ..:|:.|||||||:|||.||.||...|.:|:||:||:|||.:||.|
Mouse  1238 YFLLKAKY---AQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPT 1299

  Fly  1311 ELLPLRPLPVSCLKNVVYESLY--KFTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAI 1373
            |||.|:|||||.|:|..:||||  ||..|||||||:|:.:|::|:||.:||||||||||.||.||
Mouse  1300 ELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAI 1364

  Fly  1374 FRALNQNPKCKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELTGDVTPDIQAIRESQLIVTT 1438
            .|.|.||.:.:.|||.|::||.::...||.::|| ..|..|||.|||:.:.|::.:.:..:|::|
Mouse  1365 LRMLLQNSEGRCVYITPMEALAEQVYMDWYEKFQ-DRLNKKVVLLTGETSTDLKLLGKGNIIIST 1428

  Fly  1439 PEKWDGISRSWQTREYVQHVSLIVIDEIHLLGEDRGPVIEVIVSRTNFISSHTGRAIRIVGLSTA 1503
            |||||.:||.|:.|:.||:::|.|:||:||:|.:.|||:|||.||..:|||...|.||||.||::
Mouse  1429 PEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSS 1493

  Fly  1504 LANAQDLANWLGINKMGLYNFKPSVRPVPLQVHINGFPGKHYCPRMATMNRPTFQAIRTYSPCEP 1568
            |:||:|:|:|||.:....:||.|:||||||::||.||...|...|:.:|.:|.:.||..:||.:|
Mouse  1494 LSNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKP 1558

  Fly  1569 TIVFVSSRRQTRLTALDLITFVAGESNPKQFLHIPEDEIELILQNIREQNLKFCLAFGIGLHHAG 1633
            .||||.||:||||||:|::|..|.:...::|||..|.::...|:.:.:..||..|..|:|..|.|
Mouse  1559 VIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEG 1623

  Fly  1634 LQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGTEYFDGKVKKYVDMPITDVLQMM 1698
            |...:|:.||:||.:..||::||:.:|.||:|:.||||:|..|:|::||:..|||.||.|||||:
Mouse  1624 LSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMV 1688

  Fly  1699 GRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAALD 1763
            |.|.||..|:||..|::....||:|:|||||:|.||||.|...:.:|.|||||..|:::||.|:|
Mouse  1689 GHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVD 1753

  Fly  1764 YLTWTYFFRRLLRNPSYYQLQDIEPENVNNFMSNLVERVVYELSAAACL-VERDGCLIPTFLGRI 1827
            |||||:.:||:.:||:||.||.|...::::.:|.|||:.:.:|..:.|: :|.:..:.|..||.|
Mouse  1754 YLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMI 1818

  Fly  1828 SSYYYLSYRTMKHFLEDLQPGMNTKKVLLAIADSYEFDQLPVRHNEDKHNEEMAEVSRFRPPSSS 1892
            ::|||::|.|::.|...|......:.::..|:::.|::.:|:||:||....::|:....:..:..
Mouse  1819 AAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPK 1883

  Fly  1893 WDSSYTKTFLLLQAHFARQSLPNSDYLTDTKSALDNATRVMQAMVDYTAERGWLSTTLVVQQLMQ 1957
            ::..:.||.||||||.:|..| :::..:||:..|..|.|::||.||..:..||||..|...:|.|
Mouse  1884 FNDPHVKTNLLLQAHLSRMQL-SAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQ 1947

  Fly  1958 SVIQARWFDGSEFLTLPGVNEDNLDAFL-NIPHDDYDYLTLPVLKELCKQEYEVLAKPLRDAFE- 2020
            .|.||.|               :.|::| .:||...:::      :.|..      |.:...|:
Mouse  1948 MVTQAMW---------------SKDSYLKQLPHFTSEHI------KRCTD------KGVESVFDI 1985

  Fly  2021 -EHEIEKMYKVIQ----DLPEIAIQIFVEGRHMENEYAKRPLS---LSDDTRGEWMSLHANEDYV 2077
             |.|.|:...::|    .:.::|        ...|.|....||   :..|      |:.:....|
Mouse  1986 MEMEDEERNALLQLTDSQIADVA--------RFCNRYPNIELSYEVVDKD------SIRSGGPVV 2036

  Fly  2078 LIVNLQR-LNVSGQRRGGGQSYTVHCPKYPKPKNEAWFLTLGSQANDELLAMKRVSIRGQRCTNR 2141
            ::|.|:| ..|:|         .|..|.:|:.:.|.|::.:|...::.|:::||:::: |:...:
Mouse  2037 VLVQLEREEEVTG---------PVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQ-QKAKVK 2091

  Fly  2142 ISFQATPRLGRLQLTLYLMSDCLMGFDQQYDLQFEIIDAK 2181
            :.|.| |..|....|||.|||..||.||:|....::.:|:
Mouse  2092 LDFVA-PATGGHNYTLYFMSDAYMGCDQEYKFSVDVKEAE 2130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	9/36 (25%)
		BRR2	485..1025	CDD:440817	274/540 (51%)
		DEXHc_ASCC3_1	486..683	CDD:350778	116/197 (59%)
		SEC63	985..1298	CDD:214744	118/316 (37%)
		BRR2	1334..1859	CDD:440817	242/525 (46%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	95/188 (51%)
		SEC63	1818..2176	CDD:214744	98/368 (27%)
Snrnp200	NP_796188.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..81		8/48 (17%)
		Helicase_PWI	254..363	CDD:436309	30/136 (22%)
		Interaction with C9orf78 and WBP4. /evidence=ECO:0000250|UniProtKB:O75643	395..2129		751/1815 (41%)
		BRR2	462..1017	CDD:440817	277/556 (50%)
		DEXHc_Brr2_1	464..677	CDD:350777	120/213 (56%)
		DEAH box	615..618		2/2 (100%)
		Sec63	982..1285	CDD:460740	117/310 (38%)
		Interaction with TSSC4. /evidence=ECO:0000250|UniProtKB:O75643	1282..2136		357/902 (40%)
		BRR2	1309..1849	CDD:440817	251/540 (46%)
		DEXHc_Brr2_2	1325..1515	CDD:350779	96/190 (51%)
		DEAH box	1454..1457		2/2 (100%)
		SEC63	1809..2125	CDD:214744	98/368 (27%)