Protein Alignment obe and rqt2

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_596560.1
• Gene: rqt2 / 2539673
• PomBaseID: SPBC13G1.10C
• Length: 1935
• Species: Schizosaccharomyces pombe
• Alignment Length: 2002
• Identity: 848/2002 - (42%)
• Similarity: 1233/2002 - (61%)
• Gaps: 166/2002 - (8%)

  Fly   199 NKFSMKHTTKAAPVASTSSEAAKLSPELQTLLEISAKLDDEHLIIRVGDILGSQRSSE---VLQN 260
            |:|::|..|......:..|:::....:...|.|.               ::.|.:::|   .:|.
pombe    65 NEFALKDLTWLQNCCNEISQSSSTELDASVLFEA---------------VIMSLKATEDQCAIQE 114

  Fly   261 ELMEILGFDYFELVEKLLMERDKIARQLDQFATRSRRVMEVKQKRMEAAASGGAAERRPTVASAV 325
            :|:.::|.|:.:|:..::.....:..:          .|......:.|..|.|......:.|:
pombe   115 DLLNLVGLDHIDLISDIVANSSNLIEE----------YMNQNDTSIAAQLSDGYTSEAGSSAT-- 167

  Fly   326 VVQSAQEKQLSKMQRREEKKLQRIMRSIKDEEAEDDPNCAVAVSVQQLRMQHQRKLLEAAQREPL 390
                               ..|.::.|:|.               :..|....|.     .|.||
pombe   168 -------------------HGQGLLDSLKS---------------RPRRFSRSRD-----NRGPL 193

  Fly   391 LLSTKAAKAEYKQSSYNQPIHYPYVFDSQLLAKQHAGFIGGSRITLPDNAQRIDNKQWEEVKIPA 455
            ....:..:.|          .||:|:..:.|....:  :.|.:..||..::|.|.:::||:.:|.
pombe   194 FTGQQVFEVE----------KYPHVYGDKRLGNTIS--VIGKKFALPAGSEREDYQKYEEIIVPH 246

  Fly   456 SEPPPLSVGNKRVQIEELDDVGRLAFANCKELNRIQSVVFPVAYHSNENMLVCAPTGAGKTNVAM 520
            ::..|...|.|.::|..:|.:.|..|.:.:.||||||:|:|:||.:|||||:|||||||||:||:
pombe   247 AQRAPQMQGEKLLEISSMDILCRKTFLSYQTLNRIQSLVYPIAYKTNENMLICAPTGAGKTDVAL 311

  Fly   521 LSIVHTIRCHLEQG---------VINRDEFKIVYIAPMKALAAEMVDNFSKRLKSLQIAVRELTG 576
            |:::.||..::|..         .::||:|||||||||||||||:|:...|||..|.:..|||||
pombe   312 LAMLQTISNYVESMNLMDESEPLDVHRDDFKIVYIAPMKALAAEVVEKMGKRLAWLGLKTRELTG 376

  Fly   577 DIQLTKAEMAATQILVTTPEKWDVVTRKGSGDVALISLVELLIIDEVHLLHGERGPVVEALVART 641
            |:||||.|:|.|||||||||||||||||..||..|...|.|:||||||:||.|||.|:|:|||||
pombe   377 DMQLTKTEIAETQILVTTPEKWDVVTRKSVGDTQLAEKVRLVIIDEVHMLHDERGAVIESLVART 441

  Fly   642 LRLVESSQSMIRIVGLSATLPNYIDVAHFLRVNPMKGLFYFDSRFRPVPLDTNFVGIKSVKQLQQ 706
            .||||:||.||||||||||||||:|||.||.||..||||||.|.|||.|::.:|:|.|...::..
pombe   442 QRLVETSQQMIRIVGLSATLPNYLDVADFLGVNRYKGLFYFSSAFRPCPIEQHFIGAKGSPKIVN 506

  Fly   707 IADMDQCCYQKCVEMVQEGHQIMVFVHARNATVRTANVIRELAQQNNTSALFLPKDSAAHGLATR 771
             :::|:.|:.|.::::|||||:|:|||:|..|:.:|..:||.......:.|........:.||.|
pombe   507 -SNIDEACFDKVLKLIQEGHQVMIFVHSRKETINSAKKLREQFFHEGEADLLDNSQHEKYSLAQR 570

  Fly   772 SIQRSRNKQLVELFSCGLAMHHAGMLRADRQMVEKYFVEGHISVLVCTATLAWGVNLPAHAVIIR 836
            .:.:|:||:|.|||...:.:|:|||||:||.:.|:.|..|.:.:|.|||||||||||||:||:|:
pombe   571 DVSKSKNKELKELFKYSMGIHNAGMLRSDRHLTERLFSMGILKILCCTATLAWGVNLPAYAVLIK 635

  Fly   837 GTDIYDAKHGSFVDLGILDVLQIFGRAGRPQFDKSGVGTIITSYDKLNHYLSLLTNQFPIESNFV 901
            ||.:||.:.|||||||:|||||||||||||||:.|.|..|||::|||:||:|::|.|.||||.|.
pombe   636 GTQLYDPQKGSFVDLGVLDVLQIFGRAGRPQFESSAVAYIITTHDKLSHYISVVTQQSPIESRFT 700

  Fly   902 NCLADNLNAEIGLGTITNVDEAIEWLSYTYLFVRMRINPHVYGIEYSELEKDPTLEARRRALIMS 966
            :.|.||||||:.|||:||:|||:.||.||||::|||.||.||||.|.||.:||.|.::||.|:..
pombe   701 DRLVDNLNAEVSLGTVTNIDEAVSWLGYTYLYIRMRRNPLVYGIAYDELVEDPLLGSKRRELVSV 765

  Fly   967 AAMSLDKARMMRFNQRTMDMNITDLGRTASYFYIKYDTVETFNELMKPFMTQAEILAMISQAQEF 1031
            ||..|...:|:.:|::...:...||||.||.:||.|.||.|.|.|:|..|::|:|:|::||..||
pombe   766 AAGRLADNQMIVYNKKNGYLIPKDLGRIASNYYINYQTVSTLNNLLKSKMSEADIIALLSQCSEF 830

  Fly  1032 QQLKVRDDEMEELDEL--KNAYCKIKPYGGSENVHGKVNILIQTYLSNGYVKSFSLSSDMSYITT 1094
            .|:|.|::|..||:.|  .::.|:::  ....|..||||:::|:|:|..:|:.|:|:||.:|:..
pombe   831 SQIKSRENEHRELESLMENSSPCQLR--DSISNTSGKVNVILQSYISRAHVEDFTLTSDTNYVAQ 893

  Fly  1095 NIGRISRALFSIVLRQNNAVLSGNMLQLCKMFERRQWDFDCHLKQFPTINAETIDKLERR--GLS 1157
            |.|||:||||.|.:.:..| .:..:|.|.|..:||||.|:..|.|| .:..:...|:|.:  .||
pombe   894 NAGRITRALFEIAMSRTWA-SAFTILSLNKSIDRRQWSFEHPLLQF-DLPHDLAVKVENQCGSLS 956

  Fly  1158 VYRLRDMEHRELKEWLRSNTYADLVIRSAHELPLLEVEASLQPITRTVLRIKVDIWPSFTWNDRV 1222
            :..|.||...||.:.:.:......|.:...:||||.:...|.|:|:.|||:.::|.|:|.|:.|.
pombe   957 LEELSDMSTGELGDLIHNRKMGPTVKKFISKLPLLNINVDLLPLTKNVLRLVLNITPNFNWDMRY 1021

  Fly  1223 HGKTCQSFWLWIEDPESNYIYHSELFQVTRKLVMSGQSQQLVMTIPLKEPLPPQYYIRVSSDNWL 1287
            ||.: |.||:::||.....|.|.|...:.::.|.:  |..|..|||:..|||.|.||...||.||
pombe  1022 HGNS-QMFWIFVEDSNGLEILHHEQLLLNKRNVST--SHLLSFTIPVSNPLPSQLYIIAVSDKWL 1083

  Fly  1288 GSTTCIPLSFQHLVLPEHHPPLTELLPLRPLPVSCLKNVVYESL--YKFTHFNPIQTQIFHCLYH 1350
            |:.|..|:|..::|..:...|:||||.|:|||::.|.:.|.|.:  .:|:.||.:|||.||.:||
pombe  1084 GAETVTPVSLSNVVFHDDSNPITELLDLQPLPITALHDPVLEGICAKRFSFFNAVQTQFFHTIYH 1148

  Fly  1351 TDNNVLLGAPTGSGKTIVAEIAIFRALNQNPKCKVVYIAPLKALVKERIADWEQRFQRSSLGLKV 1415
            ||.|:.:|||||||||:.||:|.:|||:..||.|||||||:|||||||:.||..|.. ..:|:.:
pombe  1149 TDTNIFVGAPTGSGKTMAAELATWRALHNYPKSKVVYIAPMKALVKERVKDWGHRLV-EPMGISM 1212

  Fly  1416 VELTGDVTPDIQAIRESQLIVTTPEKWDGISRSWQTREYVQHVSLIVIDEIHLLGEDRGPVIEVI 1480
            :|||||..||::|:..:.:|:|||||||||:|||::|:|||.||||::|||||||.|||||:|:|
pombe  1213 IELTGDTNPDVKAVTNANIIITTPEKWDGITRSWKSRKYVQDVSLIILDEIHLLGSDRGPVLEMI 1277

  Fly  1481 VSRTNFISSHTGRAIRIVGLSTALANAQDLANWLGINKMGLYNFKPSVRPVPLQVHINGFPGKHY 1545
            |||.|:::|.|.:.:|::|||||:|||.||||||.| :.||:||:.|||||||:::|:||||:.|
pombe  1278 VSRMNYVASQTNKKVRVLGLSTAVANANDLANWLNI-RDGLFNFRHSVRPVPLEIYIDGFPGRAY 1341

  Fly  1546 CPRMATMNRPTFQAIRTYSPCEPTIVFVSSRRQTRLTALDLITFVAGESNPKQFLHIPEDEIELI 1610
            ||||.:||:|.||||:|:||.:|.::||||||||||||.|||.|...|.||::||::.|:|:|:|
pombe  1342 CPRMMSMNKPAFQAIKTHSPTQPVLIFVSSRRQTRLTAKDLIAFCGLEDNPRRFLYMDEEELEMI 1406

  Fly  1611 LQNIREQNLKFCLAFGIGLHHAGLQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKG 1675
            :..:.:::||..|.|||.||||||.|.|||..||||:|.|:|||:||:|||||||.|||||::||
pombe  1407 VSEVEDKSLKLALPFGIALHHAGLTENDRKISEELFVNNKVQILIATSTLAWGVNTPAHLVIVKG 1471

  Fly  1676 TEYFDGKVKKYVDMPITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLG 1740
            |||:|.|:..|.||.:||||||:||||||||||.|||.:.|.|.||:|||.||:..|||||.|..
pombe  1472 TEYYDAKIGGYKDMDLTDVLQMLGRAGRPQFDNSGVARIFVQDIKKSFYKHFLHSGFPVESYLHK 1536

  Fly  1741 VLPEHINAEIVAGTVQSKQAALDYLTWTYFFRRLLRNPSYYQLQDIEPENVNNFMSNLVERVVYE 1805
            ||..|:||||..||:...|.|:|:||.|||:||:.:||.||.....:.::::.::|.||.....|
pombe  1537 VLDNHLNAEIATGTIDCIQGAMDFLTCTYFYRRVHQNPVYYGADGDDQKSIDTYLSKLVVTAFNE 1601

  Fly  1806 LSAAACLVE-RDGCLIPTFLGRISSYYYLSYRTMKHFLEDLQPGMNTKKVLLAIADSYEFDQLPV 1869
            |..:||:.. .:....||.||||.|||||.:.|:::|::.:.........|..:|::.|||.|.:
pombe  1602 LEKSACIYRVNEETYAPTTLGRIVSYYYLFHTTIRNFVQKITENAEFDLALQLLAEASEFDDLAI 1666

  Fly  1870 RHNEDKHNEEMAEVSRFRPPSSSWD--SSYTKTFLLLQAHFARQSLPNSDYLTDTKSALDNATRV 1932
            |||||..|.|:.:..::.....:..  .::.|.|:|.|||.||..||..||:|||.:.||...|:
pombe  1667 RHNEDLINIEINKSLKYSAACLNLPMVDAHVKAFILTQAHMARLKLPVDDYVTDTSTVLDQVIRI 1731

  Fly  1933 MQAMVDYTAERGWLSTTLVVQQLMQSVIQARWFDGSEFLTLPGVNEDNLDAFLNIPHDDYDYLTL 1997
            :|:.:|.:||.|:....|....|||.:.||.:.......:|||:|..:       ..:..|||
pombe  1732 IQSYIDVSAELGYSHVCLQYISLMQCLKQACYPSEIYRASLPGLNASS-------EKEARDYL-- 1787

  Fly  1998 PVLKELCKQEYEVLAKPLRDAFEEHEIEKMYKVIQDLPEI-AIQIFVEGRHMENEYAKRPLSLSD 2061
                               :.|..::.:::|:::.:.|.: .|:..|...   ..|.|..:.:|.
pombe  1788 -------------------NKFAGNKTDELYQMLCNDPNVFDIESLVNSL---ISYPKMNIEVSQ 1830

  Fly  2062 DTRGEWMSLHANEDYVLIVNLQRLNVSGQRRGGGQSYTVHCPKYPKPKNEAWFLTLGSQANDELL 2126
            .:..:           |::.|:|||     :.....:.:..|.:|||::|.:|:.:......||.
pombe  1831 SSSDK-----------LLLYLRRLN-----QPLNPDFYIFAPLFPKPQSEGFFVLIIDSETQELF 1879

  Fly  2127 AMKRVSIRGQ------RCTNRISFQATPRLGRLQLTLYLMSDCLMGFDQQYD 2172
            |::|.|..|:      |.:.|||....|......:.:.::.|   |:...|:
pombe  1880 AIRRASFAGRRNDDSIRLSLRISMDIPPTCRNRNVKVMVVCD---GYPLIYE 1928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	7/39 (18%)
		BRR2	485..1025	CDD:440817	308/548 (56%)
		DEXHc_ASCC3_1	486..683	CDD:350778	136/205 (66%)
		SEC63	985..1298	CDD:214744	121/316 (38%)
		BRR2	1334..1859	CDD:440817	297/525 (57%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	115/188 (61%)
		SEC63	1818..2176	CDD:214744	95/364 (26%)
rqt2	NP_596560.1	BRR2	253..824	CDD:440817	314/571 (55%)
		DEXHc_ASCC3_1	277..483	CDD:350778	136/205 (66%)
		Sec63	787..1092	CDD:460740	120/311 (39%)
		BRR2	1132..1655	CDD:440817	297/524 (57%)
		DEXHc_ASCC3_2	1134..1321	CDD:350780	115/188 (61%)
		SEC63	1615..1934	CDD:214744	95/364 (26%)