Protein Alignment obe and Helq

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: XP_006534885.1
• Gene: Helq / 191578
• MGIID: 2176740
• Length: 1141
• Species: Mus musculus
• Alignment Length: 1015
• Identity: 215/1015 - (21%)
• Similarity: 386/1015 - (38%)
• Gaps: 265/1015 - (26%)

  Fly   355 DEEAEDDPNCAVAVSVQQLRMQHQRKLLEAAQREPLLLS---TKAAKAEYKQSSYNQPI--HYPY 414
            |..||.:|...::..|...::.:    .|..|..|..|.   ||....:.::||:.:.:  |...
Mouse   214 DVPAEPEPGSDLSFDVPSSQILY----FENPQNSPEALGDPCTKKTNGDPQKSSHEELVSSHTEQ 274

  Fly   415 VFDSQLLAKQHAGFIGGSRITLPDN--AQRIDNKQWEEVKIPASE-------PPPLSVGNKRVQI 470
            ...:...:...|......|.:|.|:  :....|.:.:....|.|:       ...:||..|.::
Mouse   275 PEPNNDFSNVRAASESSRRKSLKDHLKSTMAGNARAQTPAFPRSKHLREALLSEEISVAKKAIE- 338

  Fly   471 EELDDVG---------RLAFANCKELNRI---QSVVFPV-AYHSNENMLVCAPTGAGKTNVAMLS 522
            ...||:|         |..:...|.:.::   |.....: :....:|::...||..|||.||.:.
Mouse   339 SPSDDLGPFYSLPSKVRDLYVQLKGIKKLYDWQHTCLTLRSVQERKNLIYSLPTSGGKTLVAEIL 403

  Fly   523 IVHTIRCHLEQGVINRDEFKIVYIAPMKALAAEMVDNFS-------------------------K 562
            ::..:.|..:.         ::.|.|..|:..|.:.:.|                         :
Mouse   404 MLQELLCRQKD---------VLMILPYVAIVQEKISSLSSFGIELGFFVEEYAGSKGRFPPIKRR 459

  Fly   563 RLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWDVVTRKGSGDVALISLVELLIIDEVHLL- 626
            ..|||.||..|        ||......::.|                :.:|.:.|:::||:|::
Mouse   460 EKKSLYIATIE--------KAHSLVNALIET----------------SRLSTLGLVVVDELHMIG 500

  Fly   627 HGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNYIDVAHFLRVNPMKGLFYFDSRFRPVPL 691
            .|.||.::|..:|:.|...:::|    |:|:||||.|..|:..||:..      |:.|:||||.|
Mouse   501 EGSRGAILEMTLAKVLYTSKTTQ----IIGMSATLNNVEDLQAFLKAE------YYTSQFRPVEL 555

  Fly   692 -------DT------------NFVGIKSVKQLQQIADMDQCCYQKCVEMVQE---GHQIMVFVHA 734
                   ||            .|..:.|.|..:.:..||.   .:.|.:|.|   .:..:||..:
Mouse   556 KEFLKVNDTIYEVDSQAADGMTFSRLLSYKYSEALKKMDP---DRLVALVTEVIPNYSCLVFCPS 617

  Fly   735 RNATVRTANVIRELAQQNNTSALFLPKDSAAHGLATRSIQRSRNKQLVELFS----------C-- 787
            :.   ...||...|.:       ||.||...|          |.|:..|:..          |
Mouse   618 KK---NCENVAEMLCK-------FLSKDYLNH----------REKEKCEVIKSLRNIGNGKVCPV 662

  Fly   788 -------GLAMHHAGMLRADRQMVEKYFVEGHISVLVCTATLAWGVNLPAHAVIIRGTDIYDA-- 843
                   |:|.||:|:...:|:::|:.:..|.:.:|.||:|||.||||||..||:|...:.:.
Mouse   663 LKRTVPFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILRAPYVANTFL 727

  Fly   844 KHGSFVDLGILDVLQIFGRAGRPQFDKSGVGTIITSYDKLNHYLSLLTNQFPIE---SNFVNCLA 905
            |...:        .|:.|||||...|.:|...::.........|.|::.  |:|   |:.|....
Mouse   728 KRNQY--------KQMVGRAGRAGIDTAGESILLLQEKDKQQVLELISG--PLETCCSHLVEEFT 782

  Fly   906 DNLNA----EIGLGTITNVDEAIEWLSYTYLFVRMRI---NPHVYGIEYSELEKDPTLEARRRAL 963
            ..:.|    .|||....::.:..:::|.|:..|:.:|   ...::.|....||     ....:.|
Mouse   783 KGIQALFLSLIGLKIAASLGDIYQFMSGTFFGVQQKILLKEKSLWEITVDALE-----HLTEKGL 842

  Fly   964 IMSAAMSLDKARMMRFNQRTMDMNITDLGRTASY---FYIKY-DTVETFNELMKP---------- 1014
            :...:...::.....|       .||.||: ||:   ..:.| ||:  :.:|.|.
Mouse   843 LQKDSCGDNEGLECHF-------RITKLGQ-ASFKGAIDLAYCDTL--YRDLKKGLEGLVLESLL 897

  Fly  1015 ---FMTQAEILAMISQA------QEFQQLKVRDDEMEELDELKNAYCKIKPYGGSENVHGKV--N 1068
               ::|....||..|:.      ::|.||...:..:..|..:..::...|..|  :.|..||  |
Mouse   898 HLIYLTTPYDLAAQSEPDWMVYFKQFGQLSPTEQNVAALLGVSESFIGKKAAG--QAVRKKVDKN 960

  Fly  1069 ILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIV------LRQNNAVLSGNMLQLCKMFE 1127
            ::.:.||      ||.|.|.:.  .||:..:|.. |::.      |....|..|..:|..|:..|
Mouse   961 VVNRLYL------SFVLYSLLK--ETNVWSVSEK-FNLPRGYIQNLLMGAASFSSCVLHFCEELE 1016

  Fly  1128 RRQWDFDCHLKQFP-----TINAETIDKLERRGLSVYRLRDMEHRELKEWLR-SNTYADLVIR-- 1184
             ..|.:...|.:..     .:.||.|..:|..|:...|.:.:.:...:..:. :|...:::::
Mouse  1017 -EFWVYKALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYNAGYRSIMHLANANPEVLVKTI 1080

  Fly  1185 ------------SAHELPLLEVEASLQPITRTVLRIKVDI 1212
                        |:.::.|.|...:||.....:||:..|:
Mouse  1081 DHLSRRQARQIVSSAKMLLHEKAEALQGEAEELLRLPADL 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309
		BRR2	485..1025	CDD:440817	143/639 (22%)
		DEXHc_ASCC3_1	486..683	CDD:350778	47/226 (21%)
		SEC63	985..1298	CDD:214744	58/279 (21%)
		BRR2	1334..1859	CDD:440817
		DEXHc_ASCC3_2	1336..1525	CDD:350780
		SEC63	1818..2176	CDD:214744
Helq	XP_006534885.1	PHA03307	35..>327	CDD:223039	21/116 (18%)
		BRR2	350..917	CDD:440817	145/657 (22%)
		DEXHc_POLQ-like	350..552	CDD:350784	51/244 (21%)
		HHH_5	1043..1096	CDD:434010	5/52 (10%)