Protein Alignment obe and helq-1

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_001022911.1
• Gene: helq-1 / 175210
• WormBaseID: WBGene00021905
• Length: 923
• Species: Caenorhabditis elegans
• Alignment Length: 779
• Identity: 187/779 - (24%)
• Similarity: 311/779 - (39%)
• Gaps: 213/779 - (27%)

  Fly  1292 CIPLSFQHLVLPEHHPPLTELLPLRPLPVSCLKNVVYESLYKFTHFNPIQTQIFHCLYHTD---- 1352
            |.|       .||..|....|.|.:.||...::  :|..:.|...|...|.:   ||  :|
 Worm   132 CAP-------APEKRPETLTLDPSKCLPERDME--MYRKIKKLDKFYDWQQE---CL--SDKRLL 182

  Fly  1353 --NNVLLGAPTGSGKTIVAEIAIFR-ALNQNPKCKVVYIAPLKALVKERI---ADWEQRFQRSSL 1411
              .|.:|..|||:|||::||:.:.| |:.:  |...:.:.|..|:|:|:|   |.:|..|
 Worm   183 DGENCILSLPTGAGKTLIAEVLMLREAIVR--KRNAILVLPYVAIVQEKISALAPFEDAF----- 240

  Fly  1412 GLKVVELTGDV--TPDIQAIRESQLIVTTPEKWDGISRSWQTREYVQHVSLIVIDEIHLLGE-DR 1473
            |:.:.|...:.  .|.|:..:...:.|.|.||.:.:..|..|:..:..|.::|:||:|::|: .|
 Worm   241 GINIEEYASNKGRFPPIKRRKRVSVYVATIEKANMLINSLITQGQLDRVGMVVVDELHMIGDGGR 305

  Fly  1474 GPVIEVIVSRTNFISSHTGRAIRIVGLSTALANAQDLANWLGINKMGL--YNFKPSVRPVPLQVH 1536
            |.::|.::::  |:...||   :|||:|..|.|..||       |..|  :.:..:.|||.|...
 Worm   306 GAILEQLLAK--FLYKGTG---QIVGMSATLPNIDDL-------KFALRAFVYSTNFRPVELTEF 358

  Fly  1537 INGFPGKHYCPRMATMN----RPT-----------FQAIRTYSPCEPTIVFVSSRRQTRLTALDL 1586
            :......|.......:|    .||           .|.:....|....::|..:::.....|:
 Worm   359 VKIGQTMHQVSENGDLNPAGDLPTNNLKSTDPDGICQLLAKLIPKNSAVIFCPNKKNCENVAV-- 421

  Fly  1587 ITFVAGESNPKQFLHIPEDEIELILQNIREQN--------LKFCLAFGIGLHHAGLQEQDRKCVE 1643
               :..::.|.........|.:..||:....|        ||.|:..|:..||:||.:.:|||||
 Worm   422 ---LIAKTLPAHIRQAKRAESDAFLQSYLSDNDDERMDAVLKQCILSGVAYHHSGLTQDERKCVE 483

  Fly  1644 ELFLNRKIQILVATATLAWGVNLPAHLVVIK----GTEYFDGKVKKYVDMPITDVLQMMGRAGRP 1704
            ..|:...|.::.||:|||.|||||...|:||    |.|.. ||.:         .|||.|||||.
 Worm   484 AAFMEGLIYVVCATSTLAAGVNLPVRRVIIKAPMVGRERL-GKAQ---------YLQMAGRAGRA 538

  Fly  1705 QFDNEGVAVVLVH-DEKKNFYKKFLYDPFP-------VESSLLGVLPEHINAEIVAGTVQSKQAA 1761
            .||.:|..:.::. .|::.::::.|....|       .|.|:...:.:.:..:: |..::....|
 Worm   539 GFDTKGDCITIIKAGEEERWFREMLKSDIPRCMSSLSSEESMGSFILDCVVLKL-AENIEEIMTA 602

  Fly  1762 LDYLTWTYFFRRLLRNPSYYQLQDIEPENVNNFMSNLVER---------------VVYELSAAAC 1811
            :.|              |.:..|: .|||:...:.:.|:|               |..|.||.|.
 Worm   603 VRY--------------SLFYAQE-SPENIRKLVESSVKRLEEHYFITIEPLEQDVASEPSAQAS 652

  Fly  1812 LVER-DGCLIPTFLGR--ISSYYYLSYRTMKHFLEDLQPGMNTKKV------LLAIADSYEFDQL 1867
            .:.| .|.:.|:.||.  .::.:.....|..|  .||...:|...:      ||.|...|
 Worm   653 SIPRVPGKISPSDLGNAVFNAGFDPDEATRLH--ADLVSSLNQGVIFASHFHLLFIITPY----- 710

  Fly  1868 PVRHNEDKHNEEMAEVSRFRPPSSSWDSSYTKTFLLLQAHFARQSLPNSDYLTDTKSALDNATRV 1932
                      |::..:        :||     .|||:.     .:||:|:.....:..|:... :
 Worm   711 ----------EQVCNI--------NWD-----LFLLMY-----NALPSSERKLLAECGLEEKF-I 746

  Fly  1933 MQAM---VDYTA-------------------------------ERGWLSTTLVVQQLMQSVIQA 1962
            ::|:   ||.||                               |:|||..|     |..|:.||
 Worm   747 LEAIITRVDLTAGTPRMRLYIALMLQKIWNHEPMYTVAERFGVEKGWLQAT-----LQSSISQA 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309
		BRR2	485..1025	CDD:440817
		DEXHc_ASCC3_1	486..683	CDD:350778
		SEC63	985..1298	CDD:214744	2/5 (40%)
		BRR2	1334..1859	CDD:440817	150/598 (25%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	58/203 (29%)
		SEC63	1818..2176	CDD:214744	36/187 (19%)
helq-1	NP_001022911.1	DEXHc_POLQ-like	151..352	CDD:350784	62/226 (27%)
		BRR2	157..687	CDD:440817	147/588 (25%)