Protein Alignment obe and mus301

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: XP_551895.4
• Gene: mus301 / 1280395
• VectorBaseID: AGAMI1_008774
• Length: 1210
• Species: Anopheles gambiae
• Alignment Length: 1288
• Identity: 289/1288 - (22%)
• Similarity: 473/1288 - (36%)
• Gaps: 409/1288 - (31%)

  Fly   181 ISLLTDLAPDALLKNRTVNKFSMKHTT-KAAPVASTSSE-----AAKLSPELQTLLEISAKLDDE 239
            :::.|....|....:.:|....|.:|. .|..:.|...:     |||.:|...:||
Mosquito    46 VAVRTSKRKDDASSSSSVQLMDMDNTLFNAVDLDSIEQQIKPPPAAKEAPGSPSLL--------- 101

  Fly   240 HLIIRVGDILGSQRSSEVLQNELMEILG-----FDYFELVEKLLMERDKIARQLDQFATRSRRVM 299
                          :|.|.|:::.:..|     |...|  |||:....|  |:....|.|...|:
Mosquito   102 --------------ASRVTQSQMKKEHGKRSHSFGVIE--EKLVASTPK--RRKSTAAGRPILVL 148

  Fly   300 EVK-----QKRMEAAASGGAAERRPTVASA---------------------VVVQSAQE------ 332
            ::.     |:..|..|:|.||.|.||..|.                     ||:...|:
Mosquito   149 QMSMDGPDQEEGERDANGSAASRSPTKDSGCSERRTNTGFEDDEDEDYLLDVVIPCGQQETSTDH 213

  Fly   333 ------KQLSKMQRREEKKLQRIMRSIKDEEAEDDPNCAVAVSVQQLRMQHQRKLLEAAQR-EPL 390
                  ::||.:....:..|.::   ::|:..|...|.|:.  .|.:|:. |..:.||::: :|:
Mosquito   214 FIRDKMRRLSNVHTASQVALGQM---LEDDAFEVFTNHAIC--SQYMRLD-QSVVDEASEKIDPI 272

  Fly   391 LLSTKAAKAEYKQSSYNQPIHYPYVFDSQLLAKQH------------------------AGFIGG 431
            |.|........:.||.|.|..  .|.|||    ||                        |...||
Mosquito   273 LGSQIGRNGVGRPSSPNTPAR--DVTDSQ----QHRLQVSEVQRIFENCERTLLDLTNIAPDGGG 331

  Fly   432 SRITLPDNAQRIDNKQWEE--------VKIPASEPPPLSVGNKRVQ------------------- 469
            |:..:..:...|:   |:|        :.:.....||...|..||.
Mosquito   332 SQPRISSSLAAIN---WDEEIHHTTALLPVAVGMGPPPGNGAPRVSSLFLEKGPFFGLPNTVRRI 393

  Fly   470 ------IEELDDVGRLAFANCKELNRIQSVVFPVAYHSNENMLVCAPTGAGKTNVAMLSIVHTIR 528
                  |::|.|..|    .|..|..||         ...|::...||..|||.||.:.::..|.
Mosquito   394 LRDFRGIDDLYDWQR----ECLALPAIQ---------ERRNLIYALPTSGGKTLVAEILMLREII 445

  Fly   529 CHLEQGVINRDEFKIVYIAPMKALAAEMVDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQ---- 589
            |.|.         .:::|.|..:||.|.:...|.....||..:.|.:|.    |.:....:
Mosquito   446 CRLR---------NVIFIVPYVSLAQEKMIALSPFALELQFLLEEYSGG----KGQCPPRKRRKK 497

  Fly   590 --ILVTTPEKWDVVTRKGSGDVALI---SLVE--------LLIIDEVHLLHGE--RGPVVEALVA 639
              |.|.|.||            ||:   ||||        |::|||:|:: ||  ||..:|.::.
Mosquito   498 NTIFVCTIEK------------ALLLLDSLVEVGRANEIGLIVIDELHMI-GEQRRGACLEMMIT 549

  Fly   640 RTLRLVESSQSMIRIVGLSATLPNYIDVAHFLRVNPMKGLFYFDSRFRPVPLDTNFV-------- 696
            :    |:..::.|:|||:|||:.|..:||.|:..:      .:...||||.| ..||
Mosquito   550 K----VQVLRAGIQIVGMSATIGNLTEVARFMLAD------VYSRDFRPVEL-KEFVKCGDDLYA 603

  Fly   697 -------------GIKSVKQLQQIADMDQCCYQKCVEMVQEGHQIMVFVHARNATVRTANVIREL 748
                         .:...|:..:.||        |.|.::.              :.|.:|:|.:
Mosquito   604 VRSKGQADGGSAENVFGEKRALEFAD--------CSEELRR--------------LDTDHVVRLI 646

  Fly   749 AQ--QNNTSALFLPKDS---------AAHGLATRSIQRSRNKQ---------------LVELFSC 787
            .:  ..::..:|.|..|         |.|..|..:..|:..|:               |.:.|..
Mosquito   647 LEVIPESSCLVFCPTKSKCESLCALLANHLPARLAEHRAEEKEQIIRSLKEDGSIAPVLPQAFRV 711

  Fly   788 GLAMHHAGMLRADRQMVEKYFVEGHISVLVCTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLG 852
            |:|.||||:.:.:|:.:|..:..|.:|::|||:|||.||||||..||||...|    ..||:.|.
Mosquito   712 GVAYHHAGLTQDERRTIEDAYRAGILSLIVCTSTLAAGVNLPAKRVIIRSPYI----GNSFLSLS 772

  Fly   853 ILDVLQIFGRAGRPQFDKSGVGTIITSY-----------------------DKLNHYLSLLTNQF 894
              ...|:.|||||..|.::|...:|.:.                       |...::.||:.:..
Mosquito   773 --RYKQMVGRAGRAGFGETGESILICAQRDIPQVCEMLCAPMDIAESALIADDRAYFKSLILSAI 835

  Fly   895 PIE--------SNFVNCLADNLNAE---IGLGTITNVDEAIEWLSYTYLFVRMR-----INPHVY 943
            .::        ...|.|......||   |.|..:|  ||.|..| |....::.|     .||...
Mosquito   836 GLDLCESRDALQALVRCTLLAQQAERRSIDLAAVT--DETIVQL-YQGNAIKARHDSCLRNPPNM 897

  Fly   944 GIEYS---ELEKDPTLEARRRALIMSAA----MSLDKA-----RMMRFNQRTMDMNITDLGRTA- 995
            .:|..   |.::.|| :....|....||    :.:.||     ::::..|||..:.:..||:.|
Mosquito   898 LVEIGTAVEEDRSPT-KTGSSAPYDGAAGPTFVRVHKAAAHPGKVIKTIQRTSPLEVNRLGKAAI 961

  Fly   996 -SYFYIK-----YDTVETFNELMKPFMTQAEILAMI--SQAQEFQQLKVRDDEMEELDELKNAYC 1052
             :.|.::     ||.::...|.: ..:.:.::|.:|  ...:|. ||| .||.:..:::|.|...
Mosquito   962 RAGFNMEKAVRFYDEMKVLGERL-CVLDEYDLLHLILLEDGREV-QLK-PDDFIVLVNQLTNEQL 1023

  Fly  1053 KI-KPYG--------------GSENVHGKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRA 1102
            || :.||              .|.::..|:...::..:.:...|...|:...|....|.|.:.
Mosquito  1024 KIAERYGINNGLIAKILTRRVASGDMVSKMMRFVRVLIVHELWKQTPLAEVASRYHVNAGSLQ-- 1086

  Fly  1103 LFSIVLRQNNAVLSGNMLQLCKMFERRQWDFD-------------CHLKQFPTINAETID----- 1149
                .|..:.|..:.::|::|:... ..|.|.             |.|:..|.:...::.
Mosquito  1087 ----TLMTSTAGTAFSLLRMCEEIP-ELWAFKHLLTGMTERLTHYCKLELLPLLTLPSVKLGRAR 1146

  Fly  1150 KLERRG----LSVYRLRDMEHRELKEWLRSNTY--ADLVIRSAHELPLLEVEA 1196
            :|.|.|    .|:.|...   |||.|.:....|  |..:|.||....|.||:|
Mosquito  1147 QLFRAGYTTLASIARATS---RELVETIEHLNYRAASQLILSAKAKLLEEVDA 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	9/41 (22%)
		BRR2	485..1025	CDD:440817	160/663 (24%)
		DEXHc_ASCC3_1	486..683	CDD:350778	58/215 (27%)
		SEC63	985..1298	CDD:214744	55/260 (21%)
		BRR2	1334..1859	CDD:440817
		DEXHc_ASCC3_2	1336..1525	CDD:350780
		SEC63	1818..2176	CDD:214744
mus301	XP_551895.4	None