Protein Alignment Atg4b and ATG4C

DIOPT Version :10

• Sequence 1: NP_650452.1
• Gene: Atg4b / 41868
• FlyBaseID: FBgn0038325
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_116241.2
• Gene: ATG4C / 84938
• HGNCID: 16040
• Length: 458
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 192/578 - (33%)
• Similarity: 266/578 - (46%)
• Gaps: 186/578 - (32%)

  Fly   146 MESKLVAMWHNVKYGWSGKMRQTSFSKEQPVWLLGRCYHRRFTPPVSMESSITELPSGADTTPDN 210
            :::|.::.|:|:||.|..|.: |.||:..||.|||:|||.::      |.....||:.:..|
Human    12 LKTKFISAWNNMKYSWVLKTK-TYFSRNSPVLLLGKCYHFKY------EDEDKTLPAESGCT--- 66

  Fly   211 ATSAFDSIQATSTSTSLYPALNPQQIDEIVVPQELGMDAVENQVGEQPWEEGIEGFRRDFYSRIW 275
                                     |::.|:                  ...:|.||:||.||||
Human    67 -------------------------IEDHVI------------------AGNVEEFRKDFISRIW 88

  Fly   276 MTYRREFPIMNGSNYTSDCGWGCMLRSGQMLFAQGLICHFLGRSWRY---------DSESQLHST 331
            :|||.|||.:.||..|:||||||.||:||||.|||||.|||||:|.:         ||||....|
Human    89 LTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHT 153

  Fly   332 -------------------------------YEDN-------MHKKIVKWFGDSSSKSSPFSIHA 358
                                           |.|:       .|:||:.||||  |..:.|.:|.
Human   154 VKKFTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGD--SPLALFGLHQ 216

  Fly   359 LVRLGEHLGKKPGDWYGPASVSYLLKHALEHAAQENADFDNISVYVAKDCTIYLQDIEDQCSIPE 423
            |:..|:..|||.|||||||.|:::|:.|:|.|  .:.|...|::|||:|||:|..|:.|:.|
Human   217 LIEYGKKSGKKAGDWYGPAVVAHILRKAVEEA--RHPDLQGITIYVAQDCTVYNSDVIDKQS--- 276

  Fly   424 PAPKPHVPWQQAKRPQAETTKTEQQQHWKSLIVLIPLRLGSDKLNPVYAHCLKLLLSTEHCLGIL 488
                              .:.|......|::|:|:|:|||.::.|..|...:|.:||.|:|:||:
Human   277 ------------------ASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGII 323

  Fly   489 GGKPKHSLYFVGFQEDRLIHLDPHYCQEMVDVNQENFSLHSFHCKSPRKLKASKMDPSCCIGFYC 553
            |||||.|.||.|||:|.||::||||||..|||:.::|.|.:|||.||:|:...||||||.|||||
Human   324 GGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYC 388

  Fly   554 ATKSDFDNFMESVQLYLHPMRCASGATVDKAAGSHHTTPQSSHQTEQTEMNYPLFSFSRGRCMDH 618
            ....||....|.:...|                           ...::..||||:|..|...|:
Human   389 RNVQDFKRASEEITKML---------------------------KFSSKEKYPLFTFVNGHSRDY 426

  Fly   619 --------ERDEMSDSLYKPLIKQVASLAQELGAQLAPPQHGDEHDQDDSESEEFVLL 668
                    |.|..|:...|.|.:                          ..:||||||
Human   427 DFTSTTTNEEDLFSEDEKKQLKR--------------------------FSTEEFVLL 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg4b	NP_650452.1	Peptidase_C54	263..565	CDD:460915	148/348 (43%)
ATG4C	NP_116241.2	Peptidase_C54	76..394	CDD:460915	146/342 (43%)
		ATG4_LIR	427..458	CDD:466317	9/56 (16%)