DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerRS-m and sars2

DIOPT Version :9

Sequence 1:	NP_001262599.1	Gene:	SerRS-m / 41862	FlyBaseID:	FBgn0021750	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	NP_957473.1	Gene:	sars2 / 394154	ZFINID:	ZDB-GENE-040426-1616	Length:	510	Species:	Danio rerio

Alignment Length:	471	Identity:	167/471 - (35%)
Similarity:	256/471 - (54%)	Gaps:	66/471 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PTNSQLW---------RPLLLLRRQRSHDAKAVEAPIH------RP--VP-----------TSAQ 40
            |..|.|:         :|.|.:||. ..:|:|:.|.:.      ||  ||           ...:
Zfish    39 PVRSSLYEHVLDGYSHKPELDMRRV-CEEAEALTAELEDRRGDLRPADVPLIISVWKNLQKVQEE 102

  Fly    41 LDELE----------RNVVVRHHKNNVPLIRSLIQELDAGD--QHKLRQL---QAELE------- 83
            :..||          |.:|.:|.|:.:..:.......:.|.  :.||.||   :.|||
Zfish   103 ISHLEGRKQVVSSTVRELVGKHDKSTLSSLEEYGHAREEGRAIREKLNQLYLQEKELEKEHYCRA 167

  Fly    84 -QLPNATHPRLRDYGEEPRELAQYVHRQLTPQSRLKEFSELARALNLYRMDHLGNYTGHKSYYLT 147
             :|||.|||.:....|....:.:.|..:.....:.|...::..:|::.|...|.:.:||:||||.
Zfish   168 LRLPNRTHPSVPIGDESQARVVEVVGEKREFDFKPKGHLQIGESLDIIRQRRLSHVSGHRSYYLR 232

  Fly   148 GQLATLEQAIIQYALQAVTEHGFKLISVPDILPKEVIESCGMRTEGERTQVYKLDTGEC----LS 208
            |..|.|:.|:..:|:..:.:.||..:.|||||...|.|.|||:...:::|||.|:....    |:
Zfish   233 GAGAQLQFALQNFAMDLLQKRGFIPMVVPDILKSVVFEGCGMQPHAQKSQVYSLNPKRSPDLNLA 297

  Fly   209 GTSEMALAGFFANKLLSEDQLPLKVTAVSRCYRAETSGLQEEKGIYRVHQFNKVEMFAIC---TE 270
            ||.::.:||:|.:..::...||::....|.||||||...:|..|:||||.|.|:||..:.   |.
Zfish   298 GTGKVGVAGYFMDHAVNLKDLPVRTVCSSTCYRAETDTGRETWGLYRVHHFTKIEMLGVSANETG 362

  Fly   271 EQSEAELEEFKNIEVDLFRRLGLNFRLLDMPPCELGAPAYQKYDIEAWMPGRQMWGEISSCSNCT 335
            |:|...|::|..::.::|..|.|::|:||||..|||.|||:|:|||||||||..:|||||.||||
Zfish   363 EESSQLLDQFVTLQKEIFSSLKLHYRVLDMPTQELGPPAYRKFDIEAWMPGRGSFGEISSASNCT 427

  Fly   336 DYQARRLGIRYRRSADGQILHAHTINGTATAIPRLLIALLESYQKEDG-IEIPAVLRPFMDNQEL 399
            |||:|||.||| ...||::.:|||:|.||.||||.:||:||:||.:.| :::|.||:.:: ..|:
Zfish   428 DYQSRRLDIRY-EGEDGKLQYAHTVNATACAIPRTIIAILETYQTKKGTVQVPEVLQQYI-GMEV 490

  Fly   400 ITRNKRIPETKLVKFI 415
            |.:.|..|    :|:|
Zfish   491 IEKPKYTP----IKYI 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS-m	NP_001262599.1	SerS	60..404	CDD:223250	143/364 (39%)
SerRS-m	NP_001262599.1	class_II_aaRS-like_core	100..394	CDD:294192	126/301 (42%)
sars2	NP_957473.1	PRK05431	58..494	CDD:235461	159/438 (36%)
		Seryl_tRNA_N	58..172	CDD:299883	25/114 (22%)
		SerRS_core	185..486	CDD:238393	126/301 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583653
Domainoid	1	1.000	186	1.000	Domainoid score	I3301
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6073
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3066
OMA	1	1.010	-	-		QHG54742
OrthoDB	1	1.010	-	-		D495094at33208
OrthoFinder	1	1.000	-	-		FOG0005193
OrthoInspector	1	1.000	-	-		oto39254
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	1	1.100	-	-	LDO	PTHR11778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1456
SonicParanoid	1	1.000	-	-		X3706
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940