DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerRS-m and Sars1

DIOPT Version :9

Sequence 1:	NP_001262599.1	Gene:	SerRS-m / 41862	FlyBaseID:	FBgn0021750	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	XP_006233198.1	Gene:	Sars1 / 266975	RGDID:	628813	Length:	536	Species:	Rattus norvegicus

Alignment Length:	416	Identity:	122/416 - (29%)
Similarity:	200/416 - (48%)	Gaps:	54/416 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DELERNVVVRHHKNNVPLIRSL----IQELDAGDQHKLRQLQAE-LEQLPNATHPRLRDYGEEPR 101
            |:|..:.:.....:.:..:|.|    ||:.| |::.||...:.| |.::.|..||.:....:|..
  Rat    88 DDLTADTLAALKVSQIKKVRLLVDEAIQKCD-GERVKLEAERFENLREIGNLLHPSVPISNDEDA 151

  Fly   102 ELAQYVHRQLTPQSRLKEFS--ELARALNLYRMDHLGNYTGHKSYYLTGQLATLEQAIIQYALQA 164
            :  ..|.|.....:..|::|  :|...::.:..:......|.:.|:|.|.|..||||:|||||:.
  Rat   152 D--NKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRT 214

  Fly   165 VTEHGFKLISVPDILPKEVIESCGMRTEGERTQVYKL---------DTG---ECLSGTSEMALAG 217
            :...|:..|..|..:.|||::.....::.:. ::||:         |:.   :.|..|||..:|.
  Rat   215 LGSRGYTPIYTPFFMRKEVMQEVAQLSQFDE-ELYKVIGKGSEKSDDSSYDEKYLIATSEQPIAA 278

  Fly   218 FFANKLLSEDQLPLKVTAVSRCYRAET-SGLQEEKGIYRVHQFNKVEMFAICT--EEQSEAELEE 279
            ...::.|..:.||:|....|.|:|.|. |..::.:||:|||||.|:|.|...:  :.:|....:|
  Rat   279 LHRDEWLRPEDLPIKYAGFSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFDE 343

  Fly   280 FKNIEVDLFRRLGLNFRLLDMPPCELGAPAYQKYDIEAWMPGRQMWGEISSCSNCTDYQARRLGI 344
            ......:.::.||:.:.::::....|...|.:|.|:|||.||...:.|:.|||||||||||||.|
  Rat   344 MITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRI 408

  Fly   345 RYRRS--------------------------ADGQILHAHTINGTATAIPRLLIALLESYQKEDG 383
            ||.::                          :..::...|.:|.|..|..|.:.|:||:||.|.|
  Rat   409 RYGQTKKMMDKRKNNLRFSTQNKLEAVSSLFSPKKVEFVHMLNATMCATTRTICAILENYQTEKG 473

  Fly   384 IEIPAVLRPFMDN--QELITRNKRIP 407
            |.:|..||.||..  ||||...|..|
  Rat   474 IVVPEKLREFMPPGLQELIPFVKPAP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS-m	NP_001262599.1	SerS	60..404	CDD:223250	118/393 (30%)
SerRS-m	NP_001262599.1	class_II_aaRS-like_core	100..394	CDD:294192	98/336 (29%)
Sars1	XP_006233198.1	PLN02678	3..510	CDD:215364	122/416 (29%)
		Seryl_tRNA_N	3..>72	CDD:280549
		SerRS_core	152..484	CDD:238393	98/334 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D495094at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720