DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerRS-m and SPAC25B8.06c

DIOPT Version :9

Sequence 1:	NP_001262599.1	Gene:	SerRS-m / 41862	FlyBaseID:	FBgn0021750	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	NP_594466.2	Gene:	SPAC25B8.06c / 2541567	PomBaseID:	SPAC25B8.06c	Length:	479	Species:	Schizosaccharomyces pombe

Alignment Length:	424	Identity:	143/424 - (33%)
Similarity:	214/424 - (50%)	Gaps:	74/424 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DELERNVVVRHHK---NNVPLIRSLIQE-------------------------LDAGDQHKL--- 75
            :.::||.:.|:.:   ..||.|||||.|                         .|..::.||
pombe    60 EAVQRNCINRNLQAIAETVPKIRSLIDEKESLKNEFFPLLSLKKEITLQIERCSDPNERGKLVNE 124

  Fly    76 -RQLQAELEQ------------------LPNATHPRLRDYGEEPRELAQYVHRQLTPQS-RLKEF 120
             :.|:.:.|:                  :||.|.|.:....|:...:.|.:...|..:: .||:.
pombe   125 AKGLKKKTEEYNKIISKVTNDLYQYCLAVPNTTLPTVPVGPEDKAVVVQKIGSPLVKKTGSLKDH 189

  Fly   121 SELA-RALNLYRMDHLGNYTGHKSYYLTGQLATLEQAIIQYALQAVTEHGFKLISVPDILPKEVI 184
            .::| ..:||   :.....:||...|.||.:|.||.||..||:......|:..:..|.|:..::.
pombe   190 LQIANEGINL---EDAAQASGHSFCYTTGDIALLEMAITNYAMDFAISKGWCPVIPPTIVRTDIA 251

  Fly   185 ESCGMRTEGER-TQVYKLDT---------GECLSGTSEMALA--GFFANKLLSEDQLPLKVTAVS 237
            .:||.:...|. .|:|:||:         .:||.||:|::||  ||   |....:....||..||
pombe   252 LACGFQPRDEEGQQIYELDSYTSPLVSSPKQCLIGTAEISLAALGF---KKTFNNFTERKVVGVS 313

  Fly   238 RCYRAETSGL-QEEKGIYRVHQFNKVEMFAICTEEQSEAELEEFKNIEVDLFRRLGLNFRLLDMP 301
            |.||.|.... :|.:|:||:|:|.|||:||.....:|.....|..|.:.:....|.:..|:|:||
pombe   314 RAYRREAGARGKENRGLYRLHEFTKVELFAWTHPSRSSEMFNEIVNFQKEFVETLKIPARILNMP 378

  Fly   302 PCELGAPAYQKYDIEAWMPGRQMWGEISSCSNCTDYQARRLGIRYRRSADGQILHAHTINGTATA 366
            ..|||:.|.||||||||||.||.:|||:|.|||.:||||||..|||...|...:  ||:||||.|
pombe   379 TAELGSSASQKYDIEAWMPARQSYGEITSASNCLEYQARRLLTRYRNDKDSGFV--HTLNGTAAA 441

  Fly   367 IPRLLIALLESYQKEDG-IEIPAVLRPFMDNQEL 399
            ||||:||:||::|:||| :::|..|.|::..:.|
pombe   442 IPRLIIAILENHQQEDGTVKVPETLVPYIHKEYL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS-m	NP_001262599.1	SerS	60..404	CDD:223250	138/403 (34%)
SerRS-m	NP_001262599.1	class_II_aaRS-like_core	100..394	CDD:294192	121/309 (39%)
SPAC25B8.06c	NP_594466.2	SerS	49..479	CDD:223250	143/424 (34%)
		Seryl_tRNA_N	50..156	CDD:280549	17/95 (18%)
		SerRS_core	169..470	CDD:238393	121/308 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	153	1.000	Domainoid score	I1070
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6073
Inparanoid	1	1.050	204	1.000	Inparanoid score	I982
OMA	1	1.010	-	-		QHG54742
OrthoFinder	1	1.000	-	-		FOG0005193
OrthoInspector	1	1.000	-	-		oto100489
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	1	1.100	-	-	LDO	PTHR11778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1456
SonicParanoid	1	1.000	-	-		X3706
TreeFam	1	0.960	-	-
	14	13.860