Protein Alignment Cp190 and ZBTB40

DIOPT Version :10

• Sequence 1: NP_524359.2
• Gene: Cp190 / 41848
• FlyBaseID: FBgn0000283
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_055685.3
• Gene: ZBTB40 / 9923
• HGNCID: 29045
• Length: 1239
• Species: Homo sapiens
• Alignment Length: 952
• Identity: 157/952 - (16%)
• Similarity: 269/952 - (28%)
• Gaps: 406/952 - (42%)

  Fly     7 VKVDNWGVFFLQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYF-NVLEQTCEI-VDDA 69
            :::.|:....||:|.....:..:||.|:.. .....:.|:|||:|.:..| .:|:.|..| :|.:
Human     1 MELPNYSRQLLQQLYTLCKEQQFCDCTISI-GTIYFRAHKLVLAAASLLFKTLLDNTDTISIDAS 64

  Fly    70 LIMPNEFQADVVVPIVNFMYTGTLEFELKMYGKLLRTAKEMNM--------TVLLKLL------- 119
            ::.|.||..     ::..||||.|......:.|::..|..:.|        .:|..|:
Human    65 VVSPEEFAL-----LLEMMYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTSLVNCSVQGQ 124

  Fly   120 ---EAHRRTMENVNRQQRPPSPKGIRRRTVGQPSS--------GLP--------------QQRVL 159
               :....:.|...::...|..:.:.....|:|.|        |.|              :..|.
Human   125 VVRDVSAPSSETFRKEPEKPQVEILSSEGAGEPHSSPELAATPGGPVKAETEEAAHSVSQEMSVN 189

  Fly   160 GPSPQ--SRNVATPI--------------------AQRANTQRGSTGNTMSRTSGGSNRSPYGDS 202
            .|:.|  .||..||.                    |::.:|:.|.............|...:.|:
Human   190 SPTAQESQRNAETPAETPTTAEACSPSPAVQTFSEAKKTSTEPGCERKHYQLNFLLENEGVFSDA 254

  Fly   203 SNVKQEPTSPFEQLR--KG--------------------------------------------YN 221
            ..|.|:.....|...  ||                                            |:
Human   255 LMVTQDVLKKLEMCSEIKGPQKEMIVKCFEGEGGHSAFQRILGKVREESLDVQTVVSLLRLYQYS 319

  Fly   222 N--------NKRPAQTSLLSPPSK-------------------------KPSLEEVKEFAEQ--- 250
            |        :::|.....:.|...                         :|.:|.::...|:
Human   320 NPAVKTALLDRKPEDVDTVQPKGSTEEGKTLSVLLLEHKEDLIQCVTQLRPIMESLETAKEEFLT 384

  Fly   251 ------------------------QRM--RKQIAAE--------YGDNDPEYDGGMLYDDVHAGD 281
                                    .||  .|.:.||        .....|..  |:|.:.:...
Human   385 GTEKRVILNCCEGRTPKETIENLLHRMTEEKTLTAEGLVKLLQAVKTTFPNL--GLLLEKLQKS- 446

  Fly   282 DDDDDMPPQPSTSKQQSPQ--GTQ--------------------------TQLEHGSTTI---IL 315
                  ...|||:.|.||.  ||:                          |.|..|...:   ::
Human   447 ------ATLPSTTVQPSPDDYGTELLRRYHENLSEIFTDNQILLKMISHMTSLAPGEREVMEKLV 505

  Fly   316 KQDSPS-------------QTPT--------IIVKDSSNAKLN---------------------- 337
            |:||.|             ||.:        ::|:::....|:
Human   506 KRDSGSGGFNSLISAVLEKQTLSATAIWQLLLVVQETKTCPLDLLMEEIRREPGADAFFRAVTTP 570

  Fly   338 ----------HTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQSSATTS 392
                      |.::|.|.::|         .|:.|:..:     .|:....|||...:..|.|.|
Human   571 EHATLETILRHNQLILEAIQQ---------KIEYKLFTS-----EEEHLAETVKEILSIPSETAS 621

  Fly   393 PHKKLH--VSFKADKSTPLI--------------------------------------------- 410
            |...|.  :|...:||.|.|
Human   622 PEASLRAVLSRAMEKSVPAIEICHLLCSVHKSFPGLQPVMQELAYIGVLTKEDGEKETWKVSNKF 686

  Fly   411 ------TAQQKAASSQQKSGTSQTTGNQGT---------GANP-PANTA---------------- 443
                  ...:|||....:.|.....|..|:         .|:| ||..:
Human   687 HLEANNKEDEKAAKEDSQPGEQNDQGETGSLPGQQEKEASASPDPAKKSFICKACDKSFHFYCRL 751

  Fly   444 --------AAQKRRI---------DSK---TMHALIAQG------AENTTGPWLCLRCGVNGRPI 482
                    .|:.:::         |||   ..|.|.|.|      |.......|.:.|.:.||..
Human   752 KVHMKRCRVAKSKQVQCKECSETKDSKKELDKHQLEAHGAGGEPDAPKKKKKRLPVTCDLCGREF 816

  Fly   483 SIPSYRGFRRHLINTHKETIDPALCEHCGWRSVNNRELHFHMYMEHQTKSLLYTFAECALCNQSY 547
            :..|  |.:.|.:..|.:. .|..||.||.:...|..|..|:.:....:..:     |..|..::
Human   817 AHAS--GMQYHKLTEHFDE-KPFSCEECGAKFAANSTLKNHLRLHTGDRPFM-----CKHCLMTF 873

  Fly   548 RTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLYRHMKSY 589
            .....|..|..:.|::.....|.||:.||.|.::|.||::::
Human   874 TQASALAYHTKKKHSEGKMYACQYCDAVFAQSIELSRHVRTH 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB_POZ_CP190-like	16..125	CDD:349620	29/128 (23%)
		COG5236	<471..>594	CDD:227561	30/119 (25%)
		C2H2 Zn finger	540..568	CDD:275371	5/27 (19%)
		C2H2 Zn finger	569..586	CDD:275371	8/16 (50%)
		PTZ00121	<709..1075	CDD:173412
ZBTB40	NP_055685.3	BTB_POZ_ZBTB40	1..116	CDD:349534	29/120 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..231		15/100 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..732		8/44 (18%)
		C2H2 Zn finger	768..789	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	779..801		5/21 (24%)
		COG5048	<794..970	CDD:227381	31/130 (24%)
		C2H2 Zn finger	809..830	CDD:275368	6/22 (27%)
		C2H2 Zn finger	838..858	CDD:275368	7/19 (37%)
		C2H2 Zn finger	866..915	CDD:275368	14/48 (29%)
		SFP1	<917..1031	CDD:227516
		C2H2 Zn finger	923..942	CDD:275368
		C2H2 Zn finger	952..970	CDD:275370
		SFP1	<1001..1069	CDD:227516
		C2H2 Zn finger	1008..1028	CDD:275368
		C2H2 Zn finger	1048..1066	CDD:275368
		C2H2 Zn finger	1077..1098	CDD:275368
		C2H2 Zn finger	1106..1127	CDD:275368
		C2H2 Zn finger	1137..1154	CDD:275368