DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and ECM10

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_010884.1	Gene:	ECM10 / 856682	SGDID:	S000000756	Length:	644	Species:	Saccharomyces cerevisiae

Alignment Length:	599	Identity:	301/599 - (50%)
Similarity:	413/599 - (68%)	Gaps:	28/599 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKAP--AVGIDLGTTYSCVGVFQHGKV-EIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMN 62
            :|.|  .:|||||||.|.|.:.: ||| .||.|.:|:|||||.|||| |.|||:|:.||.|..:|
Yeast    23 TKIPDAVIGIDLGTTNSAVAIME-GKVPRIIENAEGSRTTPSVVAFTKDGERLVGEPAKRQSVIN 86

  Fly    63 PTQTIFDAKRLIGRKFDDAAVQSDMKHWPFEVVS-ADGKPKIEVTYKDEKKTFFPEEISSMVLTK 126
            ...|:|..||||||:|:||.||.|:...||::|. ::|...:|.    ..:|:.|.:|...:|.|
Yeast    87 SENTLFATKRLIGRRFEDAEVQRDINQVPFKIVKHSNGDAWVEA----RNRTYSPAQIGGFILNK 147

  Fly   127 MKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVG 191
            |||||||||.|:|.|||:||||||||:|||||||||.|.||||||::|||||||:||||||..
Yeast   148 MKETAEAYLAKSVKNAVVTVPAYFNDAQRQATKDAGQIIGLNVLRVVNEPTAAALAYGLDKSE-- 210

  Fly   192 ERNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTN 256
            .:.:.:|||||||||:|||.||:||||||||.|||||||||||..|:...:..||::...||:.:
Yeast   211 PKVIAVFDLGGGTFDISILDIDNGIFEVKSTNGDTHLGGEDFDIYLLQEIISHFKKETGIDLSND 275

  Fly   257 KRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTD------FYTSITRARFEELNADLFRSTMD 315
            :.|::|:|.|.|:||..|||:  .|.||:..|...|      .....:|.:.|.:.|.|...|:|
Yeast   276 RMAVQRIREAAEKAKIELSST--LSTEINLPFITADAAGPKHIRMPFSRVQLENITAPLIDRTVD 338

  Fly   316 PVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAIL 380
            ||:|||:||::..|.|.|::||||.:|:|||...::.|| ||:.:|::|||||||.|||:|||:|
Yeast   339 PVKKALKDARITASDISDVLLVGGMSRMPKVADTVKKLF-GKDASKAVNPDEAVALGAAIQAAVL 402

  Fly   381 HGDKSQEVQDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEG 445
            .|    ||.|:||||||||||||||.|||.:.||.||:|||.|::|.|:|.:..|..|.::|::|
Yeast   403 SG----EVTDVLLLDVTPLSLGIETLGGVFTKLIPRNSTIPNKKSQIFSTAASGQTSVEVKVFQG 463

  Fly   446 ERAMTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRL 510
            ||.:.|||.|:|.|.|:||||||:|.||||||||||||||:||:|.:.:::|::.||:....| |
Yeast   464 ERELVKDNKLIGNFTLAGIPPAPKGTPQIEVTFDIDANGIINVSAKDLASHKDSSITVAGASG-L 527

  Fly   511 SKEDIERMVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCN 575
            |..:|:|||||||:|:|:|..::..|...|..:....:.:.::.|  .:.|:..:|...:.|:.:
Yeast   528 SDTEIDRMVNEAERYKNQDRARRNAIETANKADQLANDTENSIKE--FEGKLDKTDSQRLKDQIS 590

  Fly   576 ETIKWLDANQLADK 589
            ...:.:..:|..|:
Yeast   591 SLRELVSRSQAGDE 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	301/599 (50%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	204/383 (53%)
ECM10	NP_010884.1	dnaK	29..644	CDD:234715	299/593 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810