Protein Alignment: Hsc70-4 and HSPA2

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_068814.2
• Gene: HSPA2
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Alignment Length: 652
• Identity: 531/653 (81%)
• Similarity: 583/653 (89%)
• Gaps: 17/653 (3%)

  Fly     2 SKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQT 66
            ::.||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Human     3 ARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNT 67

  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETA 131
            ||||||||||||:||.||||||||||.|||..||||::|.||.|.||||||||||||||||||.|
Human    68 IFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIA 132

  Fly   132 EAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKK--AVGERN 194
            |||||..|.:|||||||||||||||||||||||.|||||||||||||||||||||||  |.||:|
Human   133 EAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKN 197

  Fly   195 VLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRA 259
            ||||||||||||||||:|:|||||||||||||||||||||||:|:|..:|||||||||:..||||
Human   198 VLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRA 262

  Fly   260 LRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDA 324
            :|||||||||||||||||||||||||||:||.||||||||||||||||||||.|::|||||||||
Human   263 VRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDA 327

  Fly   325 KLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQ 389
            ||||..|.:||||||||||||:|:||||.|||||||||||||||||||||||||||.||||:.||
Human   328 KLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQ 392

  Fly   390 DLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN 454
            |||||||||||||||||||||:.|||||||||||||||||||||||..||:||||||||||||||
Human   393 DLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNN 457

  Fly   455 LLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMV 519
            |||||:|:||||||||||||||||||||||||||||.::||.||||||||||||||||:||:|||
Human   458 LLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMV 522

  Fly   520 NEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDAN 584
            .|||:|::|||..::.:||||.||||.:|:|.|::::.|:.|||:.|:..|||||.|.|.|||.|
Human   523 QEAERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRN 587

  Fly   585 QLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEE 649
            |:|:|:||||:|||||.||||||:||||          |||||  |:.|  |.:||.| ||||||
Human   588 QMAEKDEYEHKQKELERVCNPIISKLYQ----------GGPGG--GSGG--GGSGASG-GPTIEE 637

  Fly   650 VD 651
            ||
Human   638 VD 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	511/612 (83%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	332/377 (88%)
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	511/612 (83%)
		Nucleotide-binding domain (NBD). {ECO:0000250|UniProtKB:P11142}	2..389		337/386 (87%)
		Substrate-binding domain (SBD). {ECO:0000250|UniProtKB:P11142}	397..512		104/115 (90%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C281046519
eggNOG	1	0.900				E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D180577at33208
OrthoFinder	1	1.000				FOG0000062
OrthoInspector	1	1.000				T608766
orthoMCL	1	0.900				OOG5_126588
Panther	1	1.100			O	PTHR19375
Phylome	1	0.910		0.800	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750