Protein Alignment Hsc70-4 and Hspa4l

DIOPT Version :10

• Sequence 1: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_001099898.2
• Gene: Hspa4l / 294993
• RGDID: 1306528
• Length: 838
• Species: Rattus norvegicus
• Alignment Length: 796
• Identity: 211/796 - (26%)
• Similarity: 343/796 - (43%)
• Gaps: 204/796 - (25%)

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAK 71
            ||||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:|||:|:..|...||...|
  Rat     4 VGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIHGFK 68

  Fly    72 RLIGRKFDDAAVQSDMKHWPFEVVS-ADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135
            :|.||.|||..||::....|:|:.. .:|...::|.|.:|::.|..|:::.|:|.|:|||:|..|
  Rat    69 KLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSENAL 133

  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYG--------LDKKAVGE 192
            .|.|.:.||::|::|.|::|::...|..:||||.||::||.||.|:|||        ||:|   .
  Rat   134 KKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEK---P 195

  Fly   193 RNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNK 257
            |||:..|:|...:.||:.:.:.|..:|.:|..|.:|||.:||..||.:|..|||.|:|.::..|.
  Rat   196 RNVVFIDMGHSAYQVSVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKAKYKINVKENS 260

  Fly   258 RALRRLRTACERAKRTLS-SSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKAL 321
            |||.||...||:.|:.:| :::...:.|:......|..:.:.||:||:|.|.|......|::..:
  Rat   261 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVM 325

  Fly   322 RDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQ 386
            ..|.|.:..|:.|.:|||:||||.|:..:...|. |:::.::|.|||||.|.|:|.|||  ..:.
  Rat   326 DQANLQREDINSIEIVGGATRIPAVKEQVTRFFL-KDISTTLNADEAVARGCALQCAIL--SPAF 387

  Fly   387 EVQDLLLLDVTPLSL------GIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEG 445
            :|::..:.|:.|.|:      ..|...|...|..| |...|..:..||   ...:|..|...|..
  Rat   388 KVREFSITDLVPYSVTLSWKTSFEEGTGECEVFSK-NHPAPFSKVITF---HKKEPFELEAFYTN 448

  Fly   446 ERAMTKDNNLLGKFELSGIPPAPRG-VPQIEVTFDIDANGILNVTA------------------- 490
            ...:...:..:|.|.:..:.|...| ..:::|...|:.:||.:|.:
  Rat   449 LHEVPYPDPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDHNDAPME 513

  Fly   491 LERSTNK--------------------------ENKITITNDKGRLSKEDIERMVNEAEK----- 524
            .|.|.|:                          |.:|..|..|.:....|.:..:|:..|
  Rat   514 TEASKNEGKEDVDKMQVDQEEGGHQKCHAEHTPEEEIDHTGAKAKAPPSDKQDRINQTIKKGKIK 578

  Fly   525 ----------YRN------------------EDEKQKETIAAKNGLESYCFNMKATL-------- 553
                      ||.                  :|:.:||...|||.:|.|.::.:..|
  Rat   579 SIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKLGTVYEKFI 643

  Fly   554 ---DEDNLKTKISDSD-----------RTTILDKCNE---------------------------- 576
               |.:.|...:.|::           :...:||..|
  Rat   644 TPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDKLQELKKYGQPIQMKYVEHEERPKALNDLGKK 708

  Fly   577 ---TIKWLDANQLADKEEYEH-------------------------------------------- 594
               .:|.::|::..| |.|:|
  Rat   709 IQLVLKVIEAHRNKD-ERYDHLDPAEMEKVEKYISDSMNWLNSKMNAQNKLSLTQDPVVKVSEIV 772

  Fly   595 -RQKELEGVCNPIITK 609
             :.|||:..||||:.|
  Rat   773 TKSKELDNFCNPIVYK 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	211/796 (27%)
Hspa4l	NP_001099898.2	ASKHA_NBD_HSP70_HSPA4L	2..384	CDD:466844	146/385 (38%)