DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-4 and Hspa9

DIOPT Version :10

Sequence 1:NP_524356.1 Gene:Hsc70-4 / 41840 FlyBaseID:FBgn0266599 Length:651 Species:Drosophila melanogaster
Sequence 2:NP_001094128.2 Gene:Hspa9 / 291671 RGDID:1311806 Length:679 Species:Rattus norvegicus


Alignment Length:605 Identity:320/605 - (52%)
Similarity:406/605 - (67%) Gaps:43/605 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTQT 66
            |...||||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|..||.|...||..|
  Rat    52 KGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTPDGERLVGMPAKRQAVTNPNNT 116

  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSA-DGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130
            .:..||||||::||..||.|.|:.||::|.| :|...:|.    ..|.:.|.:|.:.||.|||||
  Rat   117 FYATKRLIGRRYDDPEVQKDTKNVPFKIVRASNGDAWVEA----HGKLYSPSQIGAFVLMKMKET 177

  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195
            ||.|||.|..||||||||||||||||||||||.|:||||||:||||||||:||||||..  ::.:
  Rat   178 AENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSE--DKVI 240

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            .::||||||||:|||.|..|:||||||.|||.|||||||..|:.|.|:||||:...|||.:..||
  Rat   241 AVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMAL 305

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTD----FYTSITRARFEELNADLFRSTMDPVEKAL 321
            :|:|.|.|:||..||||.|..|.:..|.....    ....:|||:||.:..||.:.|:.|.:||:
  Rat   306 QRVREAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIKRTIAPCQKAM 370

  Fly   322 RDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQ 386
            :||::.||.|.:::||||.||:||||:.:|||| |:..:|::|||||||.|||:|..:|.||   
  Rat   371 QDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD--- 431

  Fly   387 EVQDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTK 451
             |.|:||||||||||||||.|||.:.||.||||||||::|.|:|.:|.|..|.|:|.:|||.|..
  Rat   432 -VTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAG 495

  Fly   452 DNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIE 516
            ||.|||:|.|.|||||||||||||||||||||||::|:|.::.|.:|.:|.| ...|.|||:|||
  Rat   496 DNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVI-QSSGGLSKDDIE 559

  Fly   517 RMVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDE--DNLKTKISDSDRTTILDKCNETIK 579
            .||..||||..||.::||.:.|.|..|....:.:..::|  |.|..           |:||:.  
  Rat   560 NMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA-----------DECNKL-- 611

  Fly   580 WLDANQLADKEEYEHRQKEL 599
                     |||.. :.:||
  Rat   612 ---------KEEIS-KMREL 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-4NP_524356.1 PTZ00009 1..612 CDD:240227 320/605 (53%)
Hspa9NP_001094128.2 Interaction with NFS1. /evidence=ECO:0000250|UniProtKB:P38646 1..432 212/390 (54%)
dnaK 52..656 CDD:234715 320/605 (53%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P38646 63..431 202/374 (54%)
Interaction with FXN and ISCU. /evidence=ECO:0000250|UniProtKB:P38646 432..679 108/214 (50%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:P38646 432..441 6/8 (75%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P38646 442..679 100/204 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..679
Blue background indicates that the domain is not in the aligned region.

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