Protein Alignment: Hsc70-4 and Hspa1a

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_034609.2
• Gene: Hspa1a
• MGIID: 96244
• Length: 641
• Species: Mus musculus
• Alignment Length: 651
• Identity: 523/652 (80%)
• Similarity: 583/652 (89%)
• Gaps: 10/652 (2%)

  Fly     1 MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQ 65
            |:|..|:|||||||||||||||||||||||||||||||||||||||||||||||||||||:||..
Mouse     1 MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQN 65

  Fly    66 TIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130
            |:|||||||||||.||.||||||||||:||:...|||::|.||.|.::||||||||||||||||.
Mouse    66 TVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEI 130

  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195
            ||||||..||||||||||||||||||||||||.|||||||||||||||||||||||:...|||||
Mouse   131 AEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNV 195

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            |||||||||||||||:|||||||||:|||||||||||||||||:|||:|||||||||::.||||:
Mouse   196 LIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAV 260

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAK 325
            |||||||||||||||||||||:||||||||.||||||||||||||.:||||.|::||||||||||
Mouse   261 RRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAK 325

  Fly   326 LDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQD 390
            :||:.|||:|||||||||||||:||||.|||::||||||||||||||||||||||.||||:.|||
Mouse   326 MDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQD 390

  Fly   391 LLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455
            ||||||.|||||:|||||||:.|||||:||||||||||||||||||||||||||||||||:||||
Mouse   391 LLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNL 455

  Fly   456 LGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVN 520
            ||:||||||||||||||||||||||||||||||||.::||.|.|||||||||||||||:|||||.
Mouse   456 LGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQ 520

  Fly   521 EAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQ 585
            |||:|:.|||.|::.:||||.||||.||||:.::::.||.|:|::|:..:||||.|.|.|||:|.
Mouse   521 EAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNT 585

  Fly   586 LADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEEV 650
            ||||||:.|:::|||.||:|||:.||||||.|      |.||.    ||....||.|:|||||||
Mouse   586 LADKEEFVHKREELERVCSPIISGLYQGAGAP------GAGGF----GAQAPKGASGSGPTIEEV 640

  Fly   651 D 651
            |
Mouse   641 D 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	502/611 (82%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	325/375 (87%)
Hspa1a	NP_034609.2	PTZ00009	1..641	CDD:240227	522/650 (80%)
		Nucleotide-binding domain (NBD). {ECO:0000250|UniProtKB:P11142}	2..386		330/384 (86%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	325/375 (87%)
		Substrate-binding domain (SBD). {ECO:0000250|UniProtKB:P11142}	394..509		103/115 (90%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG0443
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D180577at33208
OrthoFinder	1	1.000				FOG0000062
OrthoInspector	1	1.000				T615594
orthoMCL	1	0.900				OOG5_126588
Panther	1	1.100			O	PTHR19375
Phylome	1	0.910		0.714	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R573
TreeFam	0	0.000	Not matched by this tool.
	9	8.850