Protein Alignment Hsc70-4 and T14G8.3

DIOPT Version :10

• Sequence 1: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_001024913.1
• Gene: T14G8.3 / 181422
• WormBaseID: WBGene00011771
• Length: 921
• Species: Caenorhabditis elegans
• Alignment Length: 683
• Identity: 194/683 - (28%)
• Similarity: 330/683 - (48%)
• Gaps: 98/683 - (14%)

  Fly     6 AVGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFD 69
            |:.||||:.:..:|:.:.| .::|:.|.:..|.||:.::|.:.||...:||....:.:|..:...
 Worm    28 AMSIDLGSQFIKIGLVKPGVPMDIVLNKESRRKTPNVISFKNDERFFAEAAAAMSSSHPQSSYNF 92

  Fly    70 AKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEV-TYKDEKKTFFPEEISSMVLTKMKETAEA 133
            ...:|.||..|.|..:..|.:||.....|...|..| .||:||  :..|.:.:|:|...|:..||
 Worm    93 LLSMIARKEGDDAFVTFQKTFPFTAFEFDEVRKTVVFPYKEEK--YNVETLLAMILWNAKKVTEA 155

  Fly   134 YLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGL-DKKAVGER--NV 195
            |..:||.:.|||||.:.|.::|:|...|..|||||:|:::|:.:|||:.||: .:|.:.|:  ::
 Worm   156 YADQTVKDVVITVPIFLNQAERRAIASAAEIAGLNLLQLLNDGSAAALNYGVFRRKEITEKPTHM 220

  Fly   196 LIFDLGGGTFDVSILSI------DDGIFEVKS--TAG---DTHLGGEDFDNRLVTHFVQEFKR-- 247
            ||:|:|......:|:..      .||..:..:  |.|   |..|||.:..|||..|..:.|:.
 Worm   221 LIYDMGAVKTTATIVQYVLESTRKDGKDKQPTLRTVGVGFDKTLGGLEITNRLRDHLEKVFRDTV 285

  Fly   248 KHKKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRS 312
            |..||::||.||:.:|....||.|:.||::.....:::||||..:|...:||...|::..||...
 Worm   286 KTSKDISTNARAIGKLHKEAERVKQVLSANKDTYAQVESLFEEQNFRAKVTREELEKMIEDLEPR 350

  Fly   313 TMDPVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQA 377
            ...|:..|:..|::..:.|..:||:|..||:|||:.:|:.:...||::..:|.|||:|.||..||
 Worm   351 IAAPILDAIGMAQISTNDIDLVVLMGAGTRVPKVKEILKTILKDKEISNFLNTDEAIAMGAVYQA 415

  Fly   378 AILHGDKSQE-----VQDLLLLDVTPLSLGIETAGGVMSVLIK----RNTTIPTKQTQTFTTYSD 433
            |  |..||.:     |.:.:|..|. ::...:|..|.|..:.|    .|..:|.: ...|::|||
 Worm   416 A--HLSKSFKVLPFNVHEKILYPVF-VNFLTKTEEGTMKPIRKSLFGENYPVPNR-VMHFSSYSD 476

  Fly   434 NQPGVLIQVYEGERAMTKDNNLLGKFELSGIPPA-----------PRGVPQIEVTFDIDANGILN 487
            :   ..|.:.:.      |.|.|...|:||:..|           .:||   :.||.||.:||::
 Worm   477 D---FKIDIQDA------DKNPLSTVEISGVKDAIEKEVTDENSVLKGV---KTTFSIDLSGIVS 529

  Fly   488 V----TALERSTNKENKITITNDKGRLSKEDIERMVNEAEKYRNEDEKQKETIAAKNGLESYCFN 548
            |    ..:|:....|.|     ||..:.|::.:....|.|:.:.:::.:|:....|...|.....
 Worm   530 VEKASVVVEKVPTPEEK-----DKYEVDKKEFDEWEKEQEELKKKEKAEKKEKEEKKKTEGEEEK 589

  Fly   549 MKATLDEDNLKTKISDSDRTTILDKCNE------------TIKW-----LDANQ---------LA 587
            .:....|:..:.|..:.::..::.|...            |||.     :|.|:         |.
 Worm   590 NEDAAGEEKTEEKTEEVEKPVVVKKTKPVEPKAKKINVALTIKETKTDNIDLNEEEVTAAKKVLG 654

  Fly   588 D---KEEYEHRQKE----LEGVCNPIITKLYQG 613
            |   ||:.:|.::|    |||:...:..:|..|
 Worm   655 DFEQKEKEKHDREEAMNRLEGLLYDLAVRLEDG 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	193/680 (28%)
T14G8.3	NP_001024913.1	ASKHA_NBD_HSP70_HYOU1	27..416	CDD:466828	129/389 (33%)