DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdr and igf1rb

DIOPT Version :9

Sequence 1:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_694501.1	Gene:	igf1rb / 245702	ZFINID:	ZDB-GENE-020503-2	Length:	1380	Species:	Danio rerio

Alignment Length:	905	Identity:	251/905 - (27%)
Similarity:	415/905 - (45%)	Gaps:	188/905 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CG-SLEI-NKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNYSLDSLA-SNVTEISDYLMVYRCTG 103
            || .::| |.|.:.::|:|||.:.|::::..:...:.:......:|: ..:|.|:|||:::|.:|
Zfish    29 CGPGIDIGNDIGNFKRLENCTVIEGYLQILLIGDKNSNNQEVFRTLSFPKLTMITDYLLLFRVSG 93

  Fly   104 LISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQSGFIRVESNPLLCFVETVD 168
            |.||.::||.|.:|||:.|.:: .:||::|..:|:::||..|..|..|.||:|.||.||::::||
Zfish    94 LESLSTLFPNLAVIRGRNLFYN-CALVIFELTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSVD 157

  Fly   169 WIYLMGNATRQHFSLKHNRPQSQC-PLCGSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPI 232
            |..:: :|...:| :..|:...:| .:|..:..|    .:...|||..|..|        |.|
Zfish   158 WSLIL-DAELNNF-IDGNKQSKECGNVCPGIMED----NSQCTRCWTSNHCQ--------KVC-- 206

  Fly   233 ACGLNGCDSAGKCCDHNCVTGC----YSQNCSLCANYQGRMGCVNQC-VASYELNKRRCIGHREC 292
            .||...|..:|:||...|:..|    ..:.|:.|.||.....||..| ..:|:....|||....|
Zfish   207 RCGQRACTDSGQCCHPQCLGSCSVPDSDRACAACQNYNHEGRCVEDCPPGTYKFEGWRCITRDFC 271

  Fly   293 RELGRIP-----LIRGYQCVKKC-PGNQKE----ILVAKGIIHCQVECNG--DFHVKSAAD-LEV 344
            .:: .:|     :|...:|:..| ||..::    :.|:.....|...|:.  |..|..:.| .:.
Zfish   272 SKV-HLPDYDRFVIHAGECISDCPPGFTRDESHGVSVSMLCTACDGPCDKICDEKVIDSVDAAQS 335

  Fly   345 LQDCVTINGSLTIEL---TNIKEKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRG 406
            |:.|..|.|:|.|.:   |||..:    |||.|..:|.:|||:|:..|..|.||:||::|..|.|
Zfish   336 LKGCTVIKGNLHINIRRGTNIASE----LENFLGLIKTVTGYIKIRSSHTLTSLSFLKSLRYIHG 396

  Fly   407 DKLVENKYALYVVNNYHLEHIWP-PNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVA 470
            ::|.:|.||...::|.||:.:|. ..|.:.|..|.|:|.|||:||..:|.::..  |:|...:..
Zfish   397 EELWDNTYAFAALDNQHLQLLWDWSQHNLTISEGKLYFRLNPKLCMSEIRKMWA--KTGIKDNFV 459

  Fly   471 DVSPNSNGERVICGDAVRSLNPKVEDLNSTAVRIILDYMDWEG-----METLIGYSYHYKEAPVQ 530
            :....:||:|..||..:  |.....:..|..::::     ||.     ...|:.:..:|||||.|
Zfish   460 ERDFRNNGDRASCGTKI--LKFTSNNTRSNQIKLM-----WESYRPSDSRDLVNFIVYYKEAPFQ 517

  Fly   531 NVTMYDGRHGCGHDNW-LMDV-VPNQSRRH---VISGLKPYTQYAYFVKTLT-------RTEYHI 583
            |:|.:||:..||.|:| :::| :|::...:   |:|.|||:||||.|||.:|       |.:..:
Zfish   518 NITEFDGQDSCGSDSWDMVNVDLPDEKILNPGVVLSTLKPWTQYAIFVKAVTLIVEDRDRDKDRL 582

  Fly   584 QIDAYSKIGYFQTLPDRPS-PV-LRIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKE 646
            .:...|::.|.:|.|..|| || :|.|.:|  ||::::.|.||..|||....|.:..::....:|
Zfish   583 HLGPQSEVVYIRTKPSAPSMPVDIRAYANS--SSKLVVRWAPPLAPNGNNTYYVLRWKQQGEDRE 645

  Fly   647 AKDKNYVNVEL--------------ENAKDIDCECAGVLPYYSGPQP---------DDEDYYNKE 688
            ....||.:.||              |:.|....|..|.......|.|         :|:.||.|
Zfish   646 LYQHNYCSKELKIPVRVSATGLTDTEDTKPTYHETGGRDKTPCCPCPKTEEDLKRIEDDIYYRK- 709

  Fly   689 QITYEDALPNLIYVSRNHDYRRKEFEKVINYEHLLSIK-----------KDEEPTRPPTTTPAPT 742
              .:|:.|.|.|:..|..|.||::...|.|...:.::.           .|:||.|
Zfish   710 --AFENFLHNAIFTPRPPDRRRRDLFGVANVTSIHTLLAGHWNLTEGNFSDDEPPR--------- 763

  Fly   743 NATLAKERLAAINYENYRLNSEKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEKCVAEEP 807
                                     |:...|:                     ::|:|:.:
Zfish   764 -------------------------REFSFLE---------------------RKVKERHI---- 778

  Fly   808 LSGYELPGTQHFYCLSQLEPETHYRITIRACVEGVVNGCSTPAEAVIKTASIQLERFIKG 867
                |:.|         |:|.|.|||.:.||.| .|..||..|....:|.:.:....|.|
Zfish   779 ----EITG---------LQPFTVYRIDLHACNE-EVRHCSAAAFVFSRTKAAEKADDIPG 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	41/115 (36%)
		Furin-like	209..332	CDD:279142	36/137 (26%)
		Recep_L_domain	347..461	CDD:279382	45/117 (38%)
		FN3	491..578	CDD:214495	33/103 (32%)
igf1rb	NP_694501.1	Recep_L_domain	47..162	CDD:279382	41/115 (36%)
		Furin-like	176..320	CDD:279142	39/158 (25%)
		FU	219..265	CDD:238021	12/45 (27%)
		Recep_L_domain	338..449	CDD:279382	45/114 (39%)
		FN3	483..595	CDD:238020	36/116 (31%)
		FN3	600..>644	CDD:238020	16/45 (36%)
		FN3	823..910	CDD:238020	1/2 (50%)
		PTKc_InsR_like	980..1255	CDD:173625
		Pkinase_Tyr	987..1253	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6341
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820