Protein Alignment Sdr and igf1ra

DIOPT Version :10

• Sequence 1: NP_650408.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: XP_073784886.1
• Gene: igf1ra / 245701
• ZFINID: ZDB-GENE-020503-1
• Length: 1433
• Species: Danio rerio
• Alignment Length: 915
• Identity: 261/915 - (28%)
• Similarity: 418/915 - (45%)
• Gaps: 196/915 - (21%)

  Fly    42 CG-SLEI-NKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNYSLDSLAS----NVTEISDYLMVYR 100
            || .::| |.|.:.:||:|||.|.|::::..:.  |.:.|.:.:...:    .:|.::||::::|
Zfish    61 CGPHIDIRNDITEFKKLENCTVVEGYLQILLIG--DKNNNLNQEHFRTLSFPKLTMVTDYILLFR 123

  Fly   101 CTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQSGFIRVESNPLLCFVE 165
            .:||.||..:||.|.:|||:.|.:: |:||::|..:|:::||..|..|..|.||:|.||.||:::
Zfish   124 VSGLDSLSVLFPNLNVIRGRNLFYN-YALVIFEMTSLKDIGLYNLRNITRGAIRIEKNPELCYLD 187

  Fly   166 TVDWIYLMGNATRQHFSLKHNRPQSQC-PLCGSLSAD------FEFIRNSSERCWNVNTTQLRPQ 223
            :|||..||......:  :..|:...:| .:|..::.|      ..|..|.|.|||..|..|
Zfish   188 SVDWSLLMDAEFNNY--IAGNKQSKECGDVCPGINEDRPHCIRTSFNDNYSYRCWTSNHCQ---- 246

  Fly   224 PPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQN----CSLCANYQGRMGCVNQCVA-SYELNK 283
                |.||..|....|..||:||...|:..|...:    |:.|.:|.....||..|.. :|:...
Zfish   247 ----KVCPKECEKRACTDAGQCCHPQCLGSCTEADNDKACAACQHYFHEDRCVEACPPDTYKFEG 307

  Fly   284 RRCIGHRECRELGRIP-----LIRGYQCVKKCP----GNQKEIL---VAKGIIHCQVECNGDFHV 336
            .|||....|..: .:|     :|...:|:..||    .|:.:.:   ...|:  |...|... .:
Zfish   308 WRCITMEMCARV-HLPSEVDFVIHNGECMPDCPPGFTRNETQSMFCSACDGL--CDKVCESK-TI 368

  Fly   337 KSAADLEVLQDCVTINGSLTIELTNIK--EKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQ 399
            .|....:.||.|..|.|:|.|   ||:  ..|...||:.:..::.:|||:::.|:..|.||:||:
Zfish   369 DSVDAAQSLQGCTVIKGNLQI---NIRRGNNIASELESFMGLIQTVTGYVRIKHTHTLGSLSFLK 430

  Fly   400 NLDAIRGDKLVENKYALYVVNNYHLEHIWP-PNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKS 463
            :|..|.|::||:|.||.:.|:|::|:::|. ..|.:.|:.|.|:|..||:||..:|.::......
Zfish   431 SLRYIVGEELVDNTYAFHAVDNHNLQYLWDWTQHNLTIKTGKLYFRFNPKLCMSEIRKMWEKTSV 495

  Fly   464 GENISVADVSPNSNGERVICGDAVRSLNPKVEDLNSTAVRIIL------DYMDWEGMETLIGYSY 522
            .|.::..||  .|||||..|...:  |..:.....||.:::..      ||.|      ||.:..
Zfish   496 REKMAEDDV--RSNGERASCESYI--LKFRSNHTQSTRIKLTWERYRPPDYRD------LISFIV 550

  Fly   523 HYKEAPVQNVTMYDGRHGCGHDNW-LMDV-VPNQSRRH---VISGLKPYTQYAYFVK--TLTRTE 580
            :|||||.||:|.:||:.|||.::| ::|| :|.:....   ::|.|||:||||.|||  ||...:
Zfish   551 YYKEAPFQNITEFDGQDGCGSNSWNMVDVDLPQEKSIDPGVLLSPLKPWTQYAIFVKAVTLVVED 615

  Fly   581 YHIQIDAYSKIGYFQTLPDRPSPVL--RIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNA 643
            .|:. .|.|::.|.:|....||..|  |.|.:|  ||.:::.|.||..|||....||:..::
Zfish   616 KHVG-GAKSEVVYIRTNASAPSMPLDARAYANS--SSSLMVKWSPPIAPNGNKTFYFLRWQQ--- 674

  Fly   644 TKEAKDKNYVNVELENAKDIDCECAGVLPYYSGPQPDDEDYYNKEQITYEDALPNLIYVSRNHDY 708
                                              |.:|.:.|                   .|:|
Zfish   675 ----------------------------------QAEDGELY-------------------QHNY 686

  Fly   709 RRKEFEKV---INYEHLLSIKKDEEPTRPPTT------TPAP-TNATL---AKERLAAINYENYR 760
            ..||. |:   |:...|..::.:.:||:....      .|.| |...|   |::|.....:||:.
Zfish   687 CSKEL-KIPIRISATSLSDMEGETKPTKSDVAGGEKGCCPCPKTKEDLKAEAEDRSYRKVFENFL 750

  Fly   761 LNS-------EKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEK-CVAEEPLSGYELP--- 814
            .||       ::|:|||..:                :::::|..|... .|.|..::..|||
Zfish   751 HNSIFTPRPPDRKRRDLMGV----------------ANSTLVSGVSRNISVLESNITQPELPEKE 799

  Fly   815 -----GTQH--FYCLSQLEPETHYRITIRACVEGVVNGCSTPAEAVIKT----------ASIQLE 862
                 |..|  |..:..|.|.|.|||.|.|| ...|:.||..|....:|          .|:..|
Zfish   800 YPFSEGKVHTEFMEIHNLRPFTVYRIDIHAC-NYEVHRCSAAAFVFSRTKPADKADDIPGSVTQE 863

  Fly   863 RFIKG 867
            |..||
Zfish   864 RDEKG 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_650408.1	Recep_L_domain	58..173	CDD:460032	42/118 (36%)
		Furin-like	210..332	CDD:395614	36/138 (26%)
		Recep_L_domain	347..461	CDD:460032	41/116 (35%)
		FN3	491..578	CDD:214495	37/99 (37%)
igf1ra	XP_073784886.1	None