Protein Alignment Sdr and igf1r

DIOPT Version :10

• Sequence 1: NP_650408.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: XP_002933351.1
• Gene: igf1r / 100329112
• XenbaseID: XB-GENE-484032
• Length: 1362
• Species: Xenopus tropicalis
• Alignment Length: 914
• Identity: 250/914 - (27%)
• Similarity: 414/914 - (45%)
• Gaps: 204/914 - (22%)

  Fly    21 LILLFLGASSPVLASSDDQTACG-SLEI-NKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNYSLD 83
            |:||.||.|:        ...|| :::| |.:.:|::|::|..:.|::::..:      .|...:
 Frog    19 LLLLCLGPSA--------GRVCGPNMDIRNDVRELKQLEDCVVIEGYLQILLI------SNAKAE 69

  Fly    84 SLAS----NVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVE 144
            ...:    .:|.|:|||:::|.:||:||.::||.|.:|||: :||..|:||::|..:|:|:||..
 Frog    70 DFRNLRFPKLTVITDYLLLFRVSGLVSLSNLFPNLTVIRGR-VLFYNYALVIFEMTDLKEIGLYN 133

  Fly   145 LLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQC-----------PLCGSL 198
            |..|..|.:|:|.|..||:|.||||..:: :|...:: :..|:|..:|           .:|...
 Frog   134 LRNITRGAVRIEKNSELCYVSTVDWSLIL-DAVYNNY-IVGNKPPKECVDLCPGAREKMQICEKS 196

  Fly   199 SADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQN----C 259
            |.:.||    ::|||:....|        |.||..||...|....:||...|:..|.:.:    |
 Frog   197 SINNEF----ADRCWSDEHCQ--------KACPGVCGKRACTDNKECCHPECLGSCMAPDNDTAC 249

  Fly   260 SLCAN--YQGRMGCVNQCVA-SYELNKRRCIGHRECRELGRIP------LIRGYQCVKKCPG--- 312
            ..|.:  |:||  ||..|.. :|:....|||...||.::..:.      :|...:||.:||.
 Frog   250 VACHHYFYEGR--CVPTCPPNTYKFEGWRCITREECAKMHIVVNSLTPFIIHKGECVYECPSGFM 312

  Fly   313 -NQKEILV---AKGIIHCQVECNGDFH-VKSAADLEVLQDCVTINGSLTIELTNIK--EKIVDAL 370
             |:.:.:.   .:|  .|...|:.... :.|....::|:.|..:.|:|.:   ||:  :.|...|
 Frog   313 LNESQSMTCSPCEG--PCPKVCDEKMKTIDSVTSAQMLEGCTVLKGNLQL---NIRKGQNIASEL 372

  Fly   371 ENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWP-PNHLV 434
            ||.|..::.:|||:|:.||..|:||:||::|..|.|::.:...|:.||.:|.:|:.:|. ..|.:
 Frog   373 ENFLGLIETVTGYVKIRHSHALVSLSFLKSLRYILGEEQMPGNYSFYVFDNNNLQQLWDWSKHNL 437

  Fly   435 IIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGDAVRSLNPKVEDLNS 499
            .|:.|.:.|..|.:||..:|::::....:....:..|:|.::||....|...|         ||.
 Frog   438 TIKEGKIRFAFNSKLCASEIYRMEEVTGTKGRQTAEDISLSTNGNMASCESHV---------LNF 493

  Fly   500 TAV-----RIIL--------DYMDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNW-LMDV 550
            |::     ||..        ||.|      ||.::.:||||...|||.|||:..||.::| ::||
 Frog   494 TSIITSKNRIKFTWERYRPPDYRD------LISFTVYYKEALFHNVTEYDGQDACGSNSWNMVDV 552

  Fly   551 VPNQSRRH----VISGLKPYTQYAYFVKTLTRT---EYHIQIDAYSKIGYFQT---LPDRPSPVL 605
            ....|:..    ::.||||:||||.:||.:|.|   ..||. .|.|||.|.:|   :|..|..|:
 Frog   553 DLPASKESDPGILLQGLKPWTQYAIYVKAITLTMLESRHIH-GAKSKIIYIRTDAAVPSIPQDVI 616

  Fly   606 RIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYVNVELENAKDIDCECAGV 670
               .:|..|||:::.|..|.:|||.:..|.|..::
 Frog   617 ---SASNSSSQLVVKWNSPSQPNGNLSYYIVRWQQ------------------------------ 648

  Fly   671 LPYYSGPQPDDEDYYNKEQITYEDALPNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTR-- 733
                   ||.|...| :....:.|.:||           ||.....|:.|.:..:.|.|..|.
 Frog   649 -------QPQDRHLY-QYNYCFRDKVPN-----------RKYANGTIDTEGVTELTKPEGNTGEK 694

  Fly   734 ------PPTTTPAPTNATLAKERLAAINYENYRLNS------EKKQRDLQDLDQHKYTIRHALPK 786
                  |.|..........|:.|..   :||:..||      .:::||:       :.:.::
 Frog   695 GHCCACPKTEAEKKAEKDEAEYRKV---FENFLHNSIFVPRPNRRRRDV-------FAVGNS--- 746

  Fly   787 CQNSHA--SVVQQVE-----EKCVAEEPLSGYELPGTQHFYCLSQLEPETHYRITIRAC-VEGVV 843
            .|.||.  :.|:...     ||...|.|....::...:....:|.|:|.|.|||.|.:| .|...
 Frog   747 TQTSHGKNTTVEDFSNFSDFEKEDVEYPFYETKIDYKRERTVISNLQPFTLYRIDIHSCNHEAEK 811

  Fly   844 NGCS 847
            .|||
 Frog   812 LGCS 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_650408.1	Recep_L_domain	58..173	CDD:460032	42/118 (36%)
		Furin-like	210..332	CDD:395614	37/141 (26%)
		Recep_L_domain	347..461	CDD:460032	38/116 (33%)
		FN3	491..578	CDD:214495	36/104 (35%)
igf1r	XP_002933351.1	Recep_L_domain	50..162	CDD:460032	42/118 (36%)
		Furin-like	176..330	CDD:395614	41/169 (24%)
		Recep_L_domain	350..465	CDD:460032	38/117 (32%)
		FN3	<492..>644	CDD:442628	58/161 (36%)
		FN3	834..921	CDD:238020
		PTKc_InsR_like	992..1268	CDD:173625