DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdr and igf1r

DIOPT Version :9

Sequence 1:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_002933351.1	Gene:	igf1r / 100329112	XenbaseID:	XB-GENE-484032	Length:	1362	Species:	Xenopus tropicalis

Alignment Length:	914	Identity:	250/914 - (27%)
Similarity:	414/914 - (45%)	Gaps:	204/914 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LILLFLGASSPVLASSDDQTACG-SLEI-NKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNYSLD 83
            |:||.||.|:        ...|| :::| |.:.:|::|::|..:.|::::..:      .|...:
Frog    19 LLLLCLGPSA--------GRVCGPNMDIRNDVRELKQLEDCVVIEGYLQILLI------SNAKAE 69

  Fly    84 SLAS----NVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVE 144
            ...:    .:|.|:|||:::|.:||:||.::||.|.:|||: :||..|:||::|..:|:|:||..
Frog    70 DFRNLRFPKLTVITDYLLLFRVSGLVSLSNLFPNLTVIRGR-VLFYNYALVIFEMTDLKEIGLYN 133

  Fly   145 LLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQC-----------PLCGSL 198
            |..|..|.:|:|.|..||:|.||||..:: :|...:: :..|:|..:|           .:|...
Frog   134 LRNITRGAVRIEKNSELCYVSTVDWSLIL-DAVYNNY-IVGNKPPKECVDLCPGAREKMQICEKS 196

  Fly   199 SADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQN----C 259
            |.:.||    ::|||:....|        |.||..||...|....:||...|:..|.:.:    |
Frog   197 SINNEF----ADRCWSDEHCQ--------KACPGVCGKRACTDNKECCHPECLGSCMAPDNDTAC 249

  Fly   260 SLCAN--YQGRMGCVNQCVA-SYELNKRRCIGHRECRELGRIP------LIRGYQCVKKCPG--- 312
            ..|.:  |:||  ||..|.. :|:....|||...||.::..:.      :|...:||.:||.
Frog   250 VACHHYFYEGR--CVPTCPPNTYKFEGWRCITREECAKMHIVVNSLTPFIIHKGECVYECPSGFM 312

  Fly   313 -NQKEILV---AKGIIHCQVECNGDFH-VKSAADLEVLQDCVTINGSLTIELTNIK--EKIVDAL 370
             |:.:.:.   .:|  .|...|:.... :.|....::|:.|..:.|:|.:   ||:  :.|...|
Frog   313 LNESQSMTCSPCEG--PCPKVCDEKMKTIDSVTSAQMLEGCTVLKGNLQL---NIRKGQNIASEL 372

  Fly   371 ENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWP-PNHLV 434
            ||.|..::.:|||:|:.||..|:||:||::|..|.|::.:...|:.||.:|.:|:.:|. ..|.:
Frog   373 ENFLGLIETVTGYVKIRHSHALVSLSFLKSLRYILGEEQMPGNYSFYVFDNNNLQQLWDWSKHNL 437

  Fly   435 IIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGDAVRSLNPKVEDLNS 499
            .|:.|.:.|..|.:||..:|::::....:....:..|:|.::||....|...|         ||.
Frog   438 TIKEGKIRFAFNSKLCASEIYRMEEVTGTKGRQTAEDISLSTNGNMASCESHV---------LNF 493

  Fly   500 TAV-----RIIL--------DYMDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNW-LMDV 550
            |::     ||..        ||.|      ||.::.:||||...|||.|||:..||.::| ::||
Frog   494 TSIITSKNRIKFTWERYRPPDYRD------LISFTVYYKEALFHNVTEYDGQDACGSNSWNMVDV 552

  Fly   551 VPNQSRRH----VISGLKPYTQYAYFVKTLTRT---EYHIQIDAYSKIGYFQT---LPDRPSPVL 605
            ....|:..    ::.||||:||||.:||.:|.|   ..||. .|.|||.|.:|   :|..|..|:
Frog   553 DLPASKESDPGILLQGLKPWTQYAIYVKAITLTMLESRHIH-GAKSKIIYIRTDAAVPSIPQDVI 616

  Fly   606 RIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYVNVELENAKDIDCECAGV 670
               .:|..|||:::.|..|.:|||.:..|.|..::
Frog   617 ---SASNSSSQLVVKWNSPSQPNGNLSYYIVRWQQ------------------------------ 648

  Fly   671 LPYYSGPQPDDEDYYNKEQITYEDALPNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTR-- 733
                   ||.|...| :....:.|.:||           ||.....|:.|.:..:.|.|..|.
Frog   649 -------QPQDRHLY-QYNYCFRDKVPN-----------RKYANGTIDTEGVTELTKPEGNTGEK 694

  Fly   734 ------PPTTTPAPTNATLAKERLAAINYENYRLNS------EKKQRDLQDLDQHKYTIRHALPK 786
                  |.|..........|:.|..   :||:..||      .:::||:       :.:.::
Frog   695 GHCCACPKTEAEKKAEKDEAEYRKV---FENFLHNSIFVPRPNRRRRDV-------FAVGNS--- 746

  Fly   787 CQNSHA--SVVQQVE-----EKCVAEEPLSGYELPGTQHFYCLSQLEPETHYRITIRAC-VEGVV 843
            .|.||.  :.|:...     ||...|.|....::...:....:|.|:|.|.|||.|.:| .|...
Frog   747 TQTSHGKNTTVEDFSNFSDFEKEDVEYPFYETKIDYKRERTVISNLQPFTLYRIDIHSCNHEAEK 811

  Fly   844 NGCS 847
            .|||
Frog   812 LGCS 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	42/118 (36%)
		Furin-like	209..332	CDD:279142	37/142 (26%)
		Recep_L_domain	347..461	CDD:279382	38/116 (33%)
		FN3	491..578	CDD:214495	36/104 (35%)
igf1r	XP_002933351.1	Recep_L_domain	50..160	CDD:366426	42/116 (36%)
		Furin-like	176..332	CDD:366287	41/171 (24%)
		Recep_L_domain	350..463	CDD:366426	38/115 (33%)
		FN3	492..604	CDD:238020	44/118 (37%)
		fn3	612..671	CDD:365830	21/110 (19%)
		FN3	834..921	CDD:238020
		PTKc_InsR_like	992..1268	CDD:173625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I6897
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920