DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup93-2 and nup93

DIOPT Version :9

Sequence 1:	NP_650404.1	Gene:	Nup93-2 / 41804	FlyBaseID:	FBgn0038274	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_998879.1	Gene:	nup93 / 407948	XenbaseID:	XB-GENE-5823109	Length:	820	Species:	Xenopus tropicalis

Alignment Length:	828	Identity:	298/828 - (35%)
Similarity:	460/828 - (55%)	Gaps:	53/828 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLQRAQNLNNDAKAECELPAVERTLQQVLRATTELHSR-VTQTG--CKEIQAHILLGSKGVDLPK 67
            |||:|:.|..:.:...|||.|||.||::.:|...|.|: :|:|.  ...::|.:||||:|:|:..
Frog     9 LLQQAEQLAAETEGVTELPHVERNLQEIQQAGERLRSKTMTRTSQESANVKASVLLGSRGLDISH 73

  Fly    68 LNQKLEALSARKTFEPLDVKADTDVRTFLKNERENAILSVIEDTKKNISDSANKQRWASMNKVWN 132
            ::|:||:|||..|||||:...|||::.|||||::||:||.||:::|.....|.:....||...|.
Frog    74 ISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFVMAEEYHRESMLVEWE 138

  Fly   133 EEKTRLLDALIAPSQNFIDLQRLPEPTIVNPLCQP-RSCLDPLELVYAQELRHYNELLLKSSHRP 196
            :.|.|:|..|:|..::.:|..:..|.:.::....| ||.||.:|:.||:::..|||.::....:|
Frog   139 QVKQRVLHTLLASGEDALDFTQESETSYISESGAPGRSSLDNVEMAYARQIYMYNEKVVSGHLQP 203

  Fly   197 NLVQKFAHLSQSFGDCRLTDMWTLLACVTQISEPLRSDPIKSR---QQRPEFVTYAKSYLERRYR 258
            :||:.....::...|..::|:|.::..:|.:.....||.:|||   |.:..|:..|..:||:.|:
Frog   204 SLVELCTEAAERLDDKNVSDLWVMVKQMTDVPLIPASDSLKSRCSVQMQMAFLRQALHFLEQSYK 268

  Fly   259 VFMC---------SQVGGSYANNSYQLVVAYVNHRFRAQQTIGLVD-TVREIPLWPLVYYGLRCG 313
            .:..         :|:||  ...:|.||.:::|.|..| ...||.| .|...|:|.|:||.:|||
Frog   269 NYTLMSVFANLQQAQLGG--VPGTYNLVRSFLNIRLPA-PIPGLQDGEVEGYPVWALIYYCMRCG 330

  Fly   314 AVKVAVEFLREA----GSSHDEFAQLV--ADRNAGETNSKIENQLRLQYANKIRNSTDAYKKAVY 372
            .:..|.:.:..|    |...:.|.:.|  .||....|.   ||:|||.|...:|.|||.||:.||
Frog   331 DLMAAQQVVNRAQHQLGDFKNCFQEYVHSKDRRLSPTT---ENKLRLHYRRAVRASTDPYKRVVY 392

  Fly   373 CILLGCDVNEVHGEVAKTIDDFLWMRLAMI--------QPGDADNYGKLQSMILEQYGEKYFNAR 429
            ||:..|||.:.|.|||...:|:||::|:.:        .|.|.....:.|..:.|.|||.:|...
Frog   393 CIIGRCDVTDNHSEVADKTEDYLWLKLSQVCFEDEANSSPQDRLTLPQFQKQLFEDYGESHFAVN 457

  Fly   430 QQPYLYFETLALTGQFEAAIEFLARQDENRAHAVHMAIALFELGLLGSARSVSQPLLSIDIKDPQ 494
            |||||||:.|.||.||||||.||.|.:..|.||||:|:|||||.||..:...|..|||::..|||
Frog   458 QQPYLYFQVLFLTAQFEAAIAFLFRLERTRCHAVHVALALFELKLLLKSTGQSAQLLSLEPGDPQ 522

  Fly   495 PLRRLNLTRLIRQYVQRFERTDTSEALHYYYTLRCLKDSKGRNMFMACVCDLVVDSGVFDTTIFD 559
            .:|.||..||:..|.::||.||..|||.|:|.||..|||:|.:||:.||.:||::|     ..||
Frog   523 GVRHLNFIRLLMLYTRKFEPTDPREALQYFYFLRNEKDSQGESMFLRCVSELVIES-----REFD 582

  Fly   560 LIFGKRQSSDQNDVNSGLFRQFECPEFDTRTMAAQVGDELAALGNFEMSARLYEMAGKYNLAVKH 624
            ::.||.:.....  ..|...:|   ..||:|:..:|.......|.||.:|:||::|...:..::.
Frog   583 MLLGKLEKDGSR--KPGAIDKF---TRDTKTIINKVASVAENKGLFEEAAKLYDLAKNPDKVLEL 642

  Fly   625 ICILMAQVVHLPTLGGSLRERLGQDAQRFNQLLASDSIDVEPKMKSSFVLLQDLLIFFNFYHDGK 689
            ...|::.||...:...|.||||...|....:...|..:..|..:.|:|.||.||:.||:.||.|.
Frog   643 TNKLLSPVVSQISAPQSNRERLKNMALAIAERYKSQGVSAEKSINSTFYLLLDLITFFDEYHAGH 707

  Fly   690 FNAALDLLRQTQLVPNTLDDVDVVLGNVKQLSGEVIKVLPDVIVAAMEIAQKQYKQLKAGSGSSL 754
            .:.|.|::.:.:|||.:.|.|:..:...:..|.|:...|.::::|.|.|...|||:||....::|
Frog   708 VDLAFDVIERLKLVPLSQDSVEERVAAFRNFSDEIRHNLSEILLATMNILFTQYKRLKGSGPNTL 772

  Fly   755 EQTQMQQ------LRQRAKALSNMAATMPYRLPNDTNKRLIELELDMH 796
            .:.|..|      ||.:|:||...|..:|||:..|||.||:::|:.|:
Frog   773 GRPQRAQEDKDSVLRSQARALITFAGMIPYRMSGDTNARLVQMEVLMN 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup93-2	NP_650404.1	DUF2461	178..>238	CDD:295279	14/59 (24%)
Nup93-2	NP_650404.1	Nic96	213..781	CDD:282017	214/600 (36%)
nup93	NP_998879.1	Nic96	220..805	CDD:367811	214/600 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	327	1.000	Domainoid score	I1181
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40971
Inparanoid	1	1.050	472	1.000	Inparanoid score	I1471
OMA	1	1.010	-	-		QHG59183
OrthoDB	1	1.010	-	-		D187731at2759
OrthoFinder	1	1.000	-	-		FOG0002723
OrthoInspector	1	1.000	-	-		otm47535
Panther	1	1.100	-	-	LDO	PTHR11225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R780
SonicParanoid	1	1.000	-	-		X3522
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110