DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup93-2 and npp106

DIOPT Version :9

Sequence 1:	NP_650404.1	Gene:	Nup93-2 / 41804	FlyBaseID:	FBgn0038274	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_588422.1	Gene:	npp106 / 2539077	PomBaseID:	SPCC1739.14	Length:	933	Species:	Schizosaccharomyces pombe

Alignment Length:	941	Identity:	185/941 - (19%)
Similarity:	365/941 - (38%)	Gaps:	211/941 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNTLLQRAQNLNNDAKAECELPAVERTLQQVLRATTELHSRVTQTGCKEIQAHILLGSKGVDLPK 67
            ::.|.:::|:|.. ...|.::|.::..|.|:......|.|:|..|...:.:||.||...|::..:
pombe    25 ISDLREKSQHLFG-VLLEPQVPVIQYGLNQLEEKARNLESKVLLTRDGDTKAHYLLAESGMNAEQ 88

  Fly    68 LNQKLEALSARKTFEPLDVKADT---DVRTFLKNERENAILSVIEDTKKNISDSANKQRWASMNK 129
            ..||:.::.....::.|::...:   ...|.|.| .:|.:.|:....:.|:.:.  :.|....|.
pombe    89 TRQKIYSIHIHSPWDQLELDKKSLYEQPHTKLYN-GQNVVASIENGYQSNVYEF--QLRLMKNNG 150

  Fly   130 V-WNEEKTRLLD---ALIAPSQNF---IDLQRLPEPTIVNPLCQPRSCLDPLELVYAQELRHYNE 187
            : |...||..::   .|:....|.   ..:.....|.:..||....|       |.:|.:|...|
pombe   151 IAWENTKTEFMEDVGKLLHSKDNSGLGTSISMSLRPNLARPLLTASS-------VKSQSVRSLRE 208

  Fly   188 L----------LLKSSHRPNLVQK------------FAHLSQSF-------GDCRLTD----MWT 219
            :          |.|.....|.:..            ||..:.||       .:.|:.:    :|:
pombe   209 VGSNLPIPTGSLTKIDGLNNQLSNDLTRSQTTNIFGFAEKASSFAAAVHKLNEARIRNQACHVWS 273

  Fly   220 LLACVTQISEPLRSDPI--------------KSRQQRPEF--------------------VTYAK 250
            |.|.|:|:   :.::.|              ::|....:|                    :..:.
pombe   274 LFASVSQM---VNTEVIQLFDAWSLLAHMIDETRYGMGDFEARHLALDSSSAALAVEKNCIEGSL 335

  Fly   251 SYLERRYRVFM---CSQVGGSYANNSYQLVVAYVNHRF--RAQQTIGLVDTVREIPLWPLVYYGL 310
            .|||.::...:   .|..|.....||.:.|:||...||  ........|..|.::|||.:::|.:
pombe   336 KYLENQFLSLIDLHLSDAGHITTVNSVEKVIAYSKLRFYKNGSWIKSTVSVVNDVPLWVVLFYLM 400

  Fly   311 RCGAVKVAVEFLREAGSSHDEFAQL----------VADRNAGETNSKIENQLRLQYANKIRNS-T 364
            |.|.:..|::|:   .:..|:|.:|          .|...:.....::.::|:.:|...::.: .
pombe   401 RSGQLDAALQFV---NTYSDDFEKLGRSFPLYFYSYAKNPSLPLPKQLRDRLQAEYGQLMKYAPE 462

  Fly   365 DAYKKAVYCILLGCDVNEVH-GEVAKTIDDFLWMRLAMIQPGDAD--------------NYGKLQ 414
            |.:|.|:|.:|..|:.:.|. .||..|.:|::|::|...:....|              |..:|:
pombe   463 DPFKHAIYKLLGNCEPHRVSLPEVCVTSEDYMWIQLMFCRVNQNDVIDSNGGQSTNSLFNLYQLE 527

  Fly   415 SMILEQYGEKYFNARQQ-PYLYFETLALTGQFEAAIEFLARQDENRAHAVHMAIALFELGLLGSA 478
            ..|: .:|.:|||.:.. |..||..|.:.|:||.||.||  .......|.|.|:|:...|||.:.
pombe   528 KKIV-AFGPRYFNPKNNTPTNYFLALLMCGEFERAISFL--HTNYPVEATHFAVAMAYYGLLRTK 589

  Fly   479 R-SVSQPLLSIDIKDPQPLRRLNLTRLIRQYVQRFERTDTSEALHYYYTLRCLKDSKGRNMFMAC 542
            . ..::.:|..:..|.    ::|..:||..|::..|..|.:..|.|   :.|:.....   :.||
pombe   590 NYEKNENILIYEADDV----KINFPQLIIAYLKHLEYVDAAVYLDY---IACIPLVPA---YQAC 644

  Fly   543 VCD----LVVDSGVFDTTIFDLIFGKRQSSDQNDVNSGLFRQF-ECPEFDTRTM-------AAQV 595
            ..:    |::.|..|...:.|:       ....:..:||...: ....||..::       |.:.
pombe   645 SINLTKILLLQSHEFSKFLGDI-------KPDTERTTGLLDLYLRLIPFDHDSLQKLYLEGAREA 702

  Fly   596 GDELAALGNFEMSARLYEMAGKYN----LAVKHICILMAQVVHLPTLGGSLRERLGQDAQRFNQL 656
            .|:    |.|..|..||.:.|.|:    :|:|:    ::|.:....| .|:..:..::....:.:
pombe   703 DDD----GRFGDSIILYHLLGDYDTVIGVAIKN----LSQSIVSRGL-WSIDSKESKNMHISSNV 758

  Fly   657 LASDSIDV-----------EPKM--------KSSFVLLQDLLIFFNFYHDGKFNAALDLLRQTQL 702
            :||::.|.           .||.        |.:..:|..::.....|...|::..|.|:....|
pombe   759 VASEAPDALAANLLAMYESNPKKSAKVSATNKKALKVLLKVVKVQKLYGQEKWDEVLQLIEHLDL 823

  Fly   703 VPNTLDDVDVVLGNVKQL-----------------SGEVIKVLPDVIVAAMEIAQKQYKQL-KAG 749
            :|  :::|.......:|:                 ..||:.|:|.::..:|...:..|:.: |..
pombe   824 LP--INEVQAEFEPNEQIPPISARLRRRAFEFSTFQDEVLSVIPSLMYISMSSIKALYRTISKLP 886

  Fly   750 SGSSLEQTQMQQLRQRAKALSNMAATMPYRL 780
            ..:...:.::|:|:.:...|...:..:..||
pombe   887 VVNEESKKKLQRLQFKGSMLVMFSTMIESRL 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup93-2	NP_650404.1	DUF2461	178..>238	CDD:295279	17/106 (16%)
Nup93-2	NP_650404.1	Nic96	213..781	CDD:282017	138/692 (20%)
npp106	NP_588422.1	Nic96	288..918	CDD:282017	131/664 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	117	1.000	Domainoid score	I1499
eggNOG	1	0.900	-	-		E1_KOG2168
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I1329
OMA	1	1.010	-	-		QHG59183
OrthoFinder	1	1.000	-	-		FOG0002723
OrthoInspector	1	1.000	-	-		mtm9264
orthoMCL	1	0.900	-	-		OOG6_103333
Panther	1	1.100	-	-	O	PTHR11225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R780
SonicParanoid	1	1.000	-	-		X3522
TreeFam	1	0.960	-	-
	13	12.860