Protein Alignment Cyp313a1 and CYP26B1

DIOPT Version :10

• Sequence 1: NP_650368.1
• Gene: Cyp313a1 / 41759
• FlyBaseID: FBgn0038236
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 117/520 - (22%)
• Similarity: 204/520 - (39%)
• Gaps: 94/520 - (18%)

  Fly     1 MLTINLLLAVGALFWIYFLWSRRRLYFLMLKIP-GPIGLPILGSSLENIITYKRKLSFRTKYLNK 64
            ::::.|||||....| ...|:..|.....|.|| |.:|.|::|.:...::   :...|::....|
Human    19 LVSVTLLLAVSQQLW-QLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLL---QGSGFQSSRREK 79

  Fly    65 YGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIV--------------NAITSCMGNGL 115
            ||:...|.:...|.|.....:.|..|...      ..|:|              |.:::.:|
Human    80 YGNVFKTHLLGRPLIRVTGAENVRKILMG------EHHLVSTEWPRSTRMLLGPNTVSNSIG--- 135

  Fly   116 LGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDT---YVDKGE-IDVVPEMLRWS 176
                |.| .::||.|:..|..:.|.|:.      .|:.:.:.||   :....| |:|..|..:.:
Human   136 ----DIH-RNKRKVFSKIFSHEALESYL------PKIQLVIQDTLRAWSSHPEAINVYQEAQKLT 189

  Fly   177 FKIAAQTTMGSEVKHDEHFKNGSLVESFESLISH-STLNILMPL------VQNRMISKICGYDKL 234
            |::|.:..:|..:..::   .|.|.|.::..:.: .:|.:.:|.      :|.|.|
Human   190 FRMAIRVLLGFSIPEED---LGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQI--------- 242

  Fly   235 RADNFSRIQKMLDNVVNKKVNPLPKTDSDPESNIVINRAMELYRKGDITYMDVKSECCIMIAAGY 299
                   :||.|:..:.:|:......|.....:::|..:.|  ...::|..::|.....:|.|.|
Human   243 -------LQKGLEKAIREKLQCTQGKDYLDALDLLIESSKE--HGKEMTMQELKDGTLELIFAAY 298

  Fly   300 DTSALTVYHALFLLANHPEHQEAVFEEL--NGVFPDAG---HFGITYPDMQKLDYLERVIKETLR 359
            .|:|......:..|..||...|.:.:||  :|:....|   ...:....:..|.||:.||||.:|
Human   299 ATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMR 363

  Fly   360 LIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKH 424
            |...|....|.......| :|..||||..:...:..||....|: .|.:.|:||.|.....|.|.
Human   364 LFTPISGGYRTVLQTFEL-DGFQIPKGWSVMYSIRDTHDTAPVF-KDVNVFDPDRFSQARSEDKD 426

  Fly   425 -PYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVDNMTMKLAEYPRLKL 488
             .:.|:||..|.|.|:|...|               |:....|..:|.......:....:||:.|
Human   427 GRFHYLPFGGGVRTCLGKHLA---------------KLFLKVLAVELASTSRFELATRTFPRITL 476

  Fly   489  488
            Human   477  476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	CYP313-like	66..487	CDD:410680	98/451 (22%)
CYP26B1	NP_063938.1	CYP26B1	60..490	CDD:410730	103/478 (22%)