Protein Alignment Kots and TDRD6

DIOPT Version :10

• Sequence 1: NP_650324.1
• Gene: Kots / 41702
• FlyBaseID: FBgn0038191
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_001010870.1
• Gene: TDRD6 / 221400
• HGNCID: 21339
• Length: 2096
• Species: Homo sapiens
• Alignment Length: 933
• Identity: 174/933 - (18%)
• Similarity: 326/933 - (34%)
• Gaps: 307/933 - (32%)

  Fly     1 MEKSEEKTCVVCGTPTRLMCQRCGEPYCNEKCQKLDWQRHRQVCIIMPPLVECRPLQPALNPIQS 65
            :.|:...|.||....|.|:.|                ::.::..:..|.:..|..::|..:....
Human   719 VSKALSDTTVVTNGSTELVVQ----------------EKVKRASVYFPLMQNCLEIKPGSSSKGE 767

  Fly    66 VENQVALAKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGPIWVVHV 130
            :|                |..||.|                        ||:::||.|..|....
Human   768 LE----------------VGSTVEV------------------------RVSYVENPGYFWCQLT 792

  Fly   131 ANVEAIERMTVNMQRCMQNKKMIRMEGVREDTLVAI---SVGDKVHRGHVLTVCQKKQEANVRMI 192
            .|::.::.:..::|...:|.....    :.:||..:   :|..:..|. :::..|..:..||..:
Human   793 RNIQGLKTLMSDIQYYCKNTAAPH----QRNTLACLAKRTVNRQWSRA-LISGIQSVEHVNVTFV 852

  Fly   193 DHGQIVATPFRDIYTIVPKMAESKAFAFRVQL-----PT--NTGVQDI---------------KN 235
            |:|.......::||:|..:..:.||.|||..|     |.  |..|.|:               ||
Human   853 DYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPVGQNPFVWDVKAIQAFNEFIDNAWQKN 917

  Fly   236 LTLR----MLGTKTSD------------GAYHVHLKPKMIIPLSL--PLE-MLQLNPEVKVIRVF 281
            |.|:    .|.:...:            .|.|..::.::..|:.|  ||| .:||:.........
Human   918 LELKCTIFALASINEELFNIVDLLTPFQSACHFLVEKRLARPVKLQKPLESSVQLHSYFYSTHDM 982

  Fly   282 KANPKH-------NEPQLALLQI----NVMGHVNADLNN------RIAEKPRQPFTLPFPEQKSI 329
            |...:.       ::|.....|:    |::..::..:..      .:...|..|.||
Human   983 KIGSEELVYITHIDDPWTFYCQLARNANILEQLSCSITQLSKVLLNLKTSPLNPGTL-------- 1039

  Fly   330 FFAATRTKNGYRRAFLLDHIMKPRPTYLVYEMDEGRVSIAT--DLSRIPS---ELLGLPS---RV 386
             ..|..|...:.|..:::  .:|:..:.|   |.|.:.:.|  ||..|||   ::|.||.   |.
Human  1040 -CLAKYTDGNWYRGIVIE--KEPKKVFFV---DFGNIYVVTSDDLLPIPSDAYDVLLLPMQAVRC 1098

  Fly   387 FAAQLEDSVPEELETQGAELTVKFKLDNKPPKEKLRAANAALNSKGEQICMARLITFLGQISYLG 451
            ..:.:.|.:|||:..
Human  1099 SLSDIPDHIPEEVVV-------------------------------------------------- 1113

  Fly   452 HKYWREPIVHDSIVFISHLVSFKEVYISTPDAKQYAEIFKRLEYKCATITKSSDVSVGSIVLVVS 516
              :::|.|:..|   :..||..|:     ||.....|::            ..::.:.:   .::
Human  1114 --WFQETILDKS---LKALVVAKD-----PDGTLIIELY------------GDNIQISA---SIN 1153

  Fly   517 KQMG--HFRGEILSKDSGLFEVMNVDTGATQKVELAEIRSSC-RFLENLPVCLMRVQLQNVCNIP 578
            |::|  .::..|..|:|   ||: ..|..|.:.:...::..| .:|..    .:..:|.|...:.
Human  1154 KKLGLLSYKDRIRKKES---EVL-CSTTETLEEKNENMKLPCTEYLSK----SVGYKLPNKEILE 1210

  Fly   579 DAAVPVNNAAIQMLHKLCAQKELLKLNMVDATTSTVDLLFSSGDSRSLTTQMLPLIFTPVQEKAE 643
            ::..|..|::.:.|..|   :.|.|.|:|.....:|      |:..|   |:.||
Human  1211 ESYKPQINSSYKELKLL---QSLTKTNLVTQYQDSV------GNKNS---QVFPL---------- 1253

  Fly   644 VAPPKAASTPSQLPVVTHKQQKVSPQSLLLLDLPPLPPSPPESPFPADVTSTK---SASHVLPIK 705
                           .|.|::::|.::       ||..:..|    |.::..|   |....||:|
Human  1254 ---------------TTEKKEEISAET-------PLKTARVE----ATLSERKIGDSCDKDLPLK 1292

  Fly   706 RFLFDALPKNLAPLGDKVNLILMNADGLPQTGYITAAYFKDEKAAKEFEKILSLTSSQGACDHNV 770
               |...|:.....|.|..:.:.:.:.|... |:  ...:||.......:.|:...::
Human  1293 ---FCEFPQKTIMPGFKTTVYVSHINDLSDF-YV--QLIEDEAEISHLSERLNSVKTR------- 1344

  Fly   771 VPGYV--PNV--GELCLAIYSEDKNWYRGVCQEVKDN-MVKILFCDFGNTEYVAVRHVKPISQ-D 829
             |.|.  |.:  |::..|::.||..|||.|.:|.:.| ::.:.|.|:||   |:|.|...|.: |
Human  1345 -PEYYVGPPLQRGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGN---VSVVHTNKIGRLD 1405

  Fly   830 LLIAV---NVTKCYINGFDKSKN 849
            |:.|:   ....|.:.||:...|
Human  1406 LVNAILPGLCIHCSLQGFEVPDN 1428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kots	NP_650324.1	zf-MYND	9..44	CDD:460312	5/34 (15%)
		TUDOR	110..225	CDD:425754	27/122 (22%)
		TUDOR	465..573	CDD:425754	18/110 (16%)
		TUDOR	743..843	CDD:425754	28/108 (26%)
TDRD6	NP_001010870.1	Tudor_TDRD6_rpt1	6..136	CDD:410491
		Tudor_TDRD6_rpt2	240..380	CDD:410492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..316
		Tudor_TDRD6_rpt3	488..622	CDD:410493
		Tudor_TDRD6_rpt4	815..893	CDD:410494	19/82 (23%)
		Tudor_SF	975..1100	CDD:470623	25/138 (18%)
		Tudor_TDRD6_rpt6	1306..1420	CDD:410496	31/127 (24%)
		Tudor_TDRD6_rpt7	1521..1663	CDD:410497