DRSC/TRiP Functional Genomics Resources

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Protein Alignment ems and Nanog

DIOPT Version :10

Sequence 1:NP_731868.1 Gene:ems / 41697 FlyBaseID:FBgn0000576 Length:494 Species:Drosophila melanogaster
Sequence 2:NP_082292.1 Gene:Nanog / 71950 MGIID:1919200 Length:305 Species:Mus musculus


Alignment Length:276 Identity:55/276 - (19%)
Similarity:80/276 - (28%) Gaps:118/276 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 ISSPHATPPQQQQQQPPPNYPKPAMMHP-------GGAGPMMMPGMPPAGLVRPFPMGPGGPPMP 280
            :..||:.|..::..........||:.||       |.|..|:..              ....|.|
Mouse     5 LPGPHSLPSSEEASNSGNASSMPAVFHPENYSCLQGSATEMLCT--------------EAASPRP 55

  Fly   281 QGQ----PGLPDIKALPPYINAPPELP--PQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAG 339
            ..:    .|.||....|....:.||..  |:...:.:.|                          
Mouse    56 SSEDLPLQGSPDSSTSPKQKLSSPEADKGPEEEENKVLA-------------------------- 94

  Fly   340 LPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLE 404
                                                          ||.| :||.||.:||..|:
Mouse    95 ----------------------------------------------RKQK-MRTVFSQAQLCALK 112

  Fly   405 HAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQED---------EKGGEGGSQR 460
            ..|:..:|:...:.:.|:..||||..|||.||||:|.|.||.|:..         :||.......
Mouse   113 DRFQKQKYLSLQQMQELSSILNLSYKQVKTWFQNQRMKCKRWQKNQWLKTSNGLIQKGSAPVEYP 177

  Fly   461 NMH---------NGSG 467
            ::|         |.||
Mouse   178 SIHCSYPQGYLVNASG 193

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
emsNP_731868.1 Homeodomain 389..445 CDD:459649 24/55 (44%)
NanogNP_082292.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..95 10/134 (7%)
Sufficient for interaction with SALL4. /evidence=ECO:0000269|PubMed:16840789 96..155 27/59 (46%)
Homeodomain 98..153 CDD:459649 24/55 (44%)
Required for DNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H9S0 123..152 14/28 (50%)
PTZ00395 <190..>250 CDD:185594 3/4 (75%)
10 X repeats starting with a Trp in each unit 198..247
Sufficient for transactivation activity 198..247
Sufficient for strong transactivation activity 248..305
Blue background indicates that the domain is not in the aligned region.

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