Protein Alignment ems and HOXB5

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Alignment Length: 239
• Identity: 65/239 - (27%)
• Similarity: 93/239 - (38%)
• Gaps: 54/239 - (22%)

  Fly   241 NYPKPAMMHPGGAGPMMMPGMPPA-----------GLV----RPFPMGPGGPPMPQGQPGLPDIK 290
            :|..||.||.|..| ....||..:           |.|    |.||.....|...|.
Human    33 SYRDPAAMHTGSYG-YNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPAQEPRFRQA-------- 88

  Fly   291 ALPPYINAPPELP----PQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNP 351
            |....:::|..||    ..|.....|::....|.:..:.........|:|::. |..||..:.:|
Human    89 ASSCSLSSPESLPCTNGDSHGAKPSASSPSDQATSASSSANFTEIDEASASSE-PEEAASQLSSP 152

  Fly   352 GMAR---------------DSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLL 401
            .:||               .:.|::||:...|   ..|...|.       ..||.|||::..|.|
Human   153 SLARAQPEPMATSTAAPEGQTPQIFPWMRKLH---ISHDMTGP-------DGKRARTAYTRYQTL 207

  Fly   402 KLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKR 445
            :||..|..|:|:....|..:|..|.|||.|:|:||||||.|.|:
Human   208 ELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKK 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	27/55 (49%)
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	22/112 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		18/104 (17%)
		Antp-type hexapeptide	176..181		2/4 (50%)
		Homeodomain	195..251	CDD:459649	27/55 (49%)