Protein Alignment ems and HOXB4

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_076920.1
• Gene: HOXB4 / 3214
• HGNCID: 5115
• Length: 251
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 76/283 - (26%)
• Similarity: 104/283 - (36%)
• Gaps: 73/283 - (25%)

  Fly   185 PPAMEQAENPAQRIQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQ-----QQQQQPPPNYPK 244
            ||..|.::  :..:...|:|......|..:.|..|........|...|     :....|||..|.
Human    18 PPCEEYSQ--SDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAACTVQRYAACRDPGPPPPPPPP 80

  Fly   245 PAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPPMPQGQPGLPDIKALPPYINAPPELPPQHNPH 309
            |....|.|..| ..|..||||.:.|             :||    :......::||..|...||
Human    81 PPPPPPPGLSP-RAPAPPPAGALLP-------------EPG----QRCEAVSSSPPPPPCAQNP- 126

  Fly   310 LIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSYQLYPWLLSRHGRIFPH 374
                              |.|:         |.|:|...|         .:|||:...|......
Human   127 ------------------LHPS---------PSHSACKEP---------VVYPWMRKVHVSTVNP 155

  Fly   375 RFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNR 439
            .:.|.       :|||.|||::..|:|:||..|..|:|:....|..:|..|.|||.|:|:|||||
Human   156 NYAGG-------EPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNR 213

  Fly   440 RTK----HKRMQQEDEKGGEGGS 458
            |.|    ||....:...||..||
Human   214 RMKWKKDHKLPNTKIRSGGAAGS 236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	28/59 (47%)
HOXB4	NP_076920.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..134		34/163 (21%)
		Antp-type hexapeptide	141..146		3/4 (75%)
		Homeodomain	163..219	CDD:459649	27/55 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..251		6/17 (35%)