Protein Alignment ems and HOXA1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_005513.2
• Gene: HOXA1 / 3198
• HGNCID: 5099
• Length: 335
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 78/304 - (25%)
• Similarity: 112/304 - (36%)
• Gaps: 88/304 - (28%)

  Fly   181 RSPAPPAMEQAENPAQRIQPPHTPPKSVSPQ-SSQPSSSPTLLISSPHATPPQQQQQQPPPNYPK 244
            |.|.|...:.:.|..  :...|:   |..|. .||..|:|    .||:|.   .|:......||:
Human    73 RHPQPATYQTSGNLG--VSYSHS---SCGPSYGSQNFSAP----YSPYAL---NQEADVSGGYPQ 125

  Fly   245 --PAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPPM----PQGQPGLPDIKALPPYINAPPELP 303
              ||:.....:.||:.......|    :..|..|.|.    ..||.  ....||..|.|:   |.
Human   126 CAPAVYSGNLSSPMVQHHHHHQG----YAGGAVGSPQYIHHSYGQE--HQSLALATYNNS---LS 181

  Fly   304 PQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMARDSYQLYPWLLSRH 368
            |.|..|       |.|....|.....||                           |.:.|:..:.
Human   182 PLHASH-------QEACRSPASETSSPA---------------------------QTFDWMKVKR 212

  Fly   369 -----GRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLS 428
                 |::..:.:.|        :|..:||.|:..||.:||..|..|:|:..|.|..:|.:|.|:
Human   213 NPPKTGKVGEYGYLG--------QPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLN 269

  Fly   429 ETQVKVWFQNRRTKHKRMQQE-------------DEKGGEGGSQ 459
            |||||:||||||.|.|:.::|             |||..|...:
Human   270 ETQVKIWFQNRRMKQKKREKEGLLPISPATPPGNDEKAEESSEK 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	27/55 (49%)
HOXA1	NP_005513.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..80		3/6 (50%)
		Interaction with OGT. /evidence=ECO:0000250|UniProtKB:P09022	75..203		39/182 (21%)
		COG5576	176..>286	CDD:227863	43/154 (28%)
		Antp-type hexapeptide	204..209		1/4 (25%)
		Homeodomain	233..286	CDD:459649	27/52 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..335		8/33 (24%)