Protein Alignment ems and RAX

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_038463.2
• Gene: RAX / 30062
• HGNCID: 18662
• Length: 346
• Species: Homo sapiens
• Alignment Length: 248
• Identity: 67/248 - (27%)
• Similarity: 85/248 - (34%)
• Gaps: 99/248 - (39%)

  Fly   248 MHPGGAGPMMMPG-MPPAG-LVRPFPMGPGGP-----------------------PMPQGQPGLP 287
            ||..|..|.|..| ...|| |:|    .|||.                       |..:|..|..
Human     1 MHLPGCAPAMADGSFSLAGHLLR----SPGGSTSRLHSIEAILGFTKDDGILGTFPAERGARGAK 61

  Fly   288 D----IKALPPYINAP-----PELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPH 343
            :    :.|.|....||     |..||                        .||.|....|..|
Human    62 ERDRRLGARPACPKAPEEGSEPSPPP------------------------APAPAPEYEAPRP-- 100

  Fly   344 AAQFMP-NPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVP------------PFRKPKRIRTAF 395
               :.| .||.||.|                   ||..:.|            |.:|.:|.||.|
Human   101 ---YCPKEPGEARPS-------------------PGLPVGPATGEAKLSEEEQPKKKHRRNRTTF 143

  Fly   396 SPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRMQQ 448
            :..||.:||.|||.:.|.....|:.||..:||.|.:|:|||||||.|.:|.::
Human   144 TTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEK 196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	27/55 (49%)
RAX	NP_038463.2	Octapeptide motif	33..40		0/6 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..145		30/146 (21%)
		Homeodomain	137..193	CDD:459649	27/55 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..318		0/3 (0%)
		OAR	319..335	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	323..336
		Nuclear localization signal. /evidence=ECO:0000255	329..333