Protein Alignment ems and TLX3

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_066305.2
• Gene: TLX3 / 30012
• HGNCID: 13532
• Length: 291
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 82/303 - (27%)
• Similarity: 119/303 - (39%)
• Gaps: 96/303 - (31%)

  Fly   192 ENPAQRIQPPHTPPKSVSPQSSQPSSSPTLLISSPHATPPQQQQQQPPPNYPKPAMM---HPGGA 253
            |.||. .|.|| |.:.:|....|..:||             .|...|.|..|..|..   .|||.
Human     2 EAPAS-AQTPH-PHEPISFGIDQILNSP-------------DQDSAPAPRGPDGASYLGGPPGGR 51

  Fly   254 GPMMMPGMP-----------------------PAGLV-----RPFPMGPGGPPMPQGQPGLPDIK 290
            .....|.:|                       |||::     ||.| |...||:|...|.:|.:
Human    52 PGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLP-GAVPPPLPSALPAMPSV- 114

  Fly   291 ALPPYINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPNPGMAR 355
               |.:::   |...:.|.:.::.:|          |.....||||
Human   115 ---PTVSS---LGGLNFPWMESSRRF----------VKDRFTAAAA------------------- 144

  Fly   356 DSYQLYPWLLSRH-GRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERK 419
                |.|:.::|. |..:.:|.|     |..:||   ||:||..|:.:||..|...:|:..|||.
Human   145 ----LTPFTVTRRIGHPYQNRTP-----PKRKKP---RTSFSRVQICELEKRFHRQKYLASAERA 197

  Fly   420 ALAQNLNLSETQVKVWFQNRRTKHKRMQQEDEKGGEGGSQRNM 462
            |||::|.:::.|||.||||||||.:|...|:.:.....:.|.|
Human   198 ALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLM 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	27/55 (49%)
TLX3	NP_066305.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		19/68 (28%)
		Homeodomain	167..223	CDD:459649	29/58 (50%)