Protein Alignment CG9297 and IRS4

DIOPT Version :10

• Sequence 1: NP_788674.1
• Gene: CG9297 / 41688
• FlyBaseID: FBgn0038181
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_012944.3
• Gene: IRS4 / 853889
• SGDID: S000001727
• Length: 615
• Species: Saccharomyces cerevisiae
• Alignment Length: 607
• Identity: 101/607 - (16%)
• Similarity: 184/607 - (30%)
• Gaps: 197/607 - (32%)

  Fly   239 VKNDEDEDLDGDGKVNHEDEDLDGDGVKN---------EKDDDLDGDGTNNSQDEDLDGDGV--- 291
            :|.....|::...|  |.......|.|.:         .....|..| .|:|....||...|
Yeast    85 IKTTAPNDVELSKK--HRSSPAGKDNVSSTAQMAAALAHSQSKLSSD-NNSSHSSALDTLKVLET 146

  Fly   292 PNEKDDDLDGDGILNEHDGDVDGDGVPNEHDHKDSGENADDDDDDD------------------- 337
            ||.       :|:|..|......:|   .::....|:...|:...:
Yeast   147 PNL-------NGLLGIHSRSSSRNG---SNESLTPGQRTPDNRSQENLLTSFSSGRRLSSSSMEP 201

  Fly   338 --DEDDKEAVKKRSKREVDAAPVLDIEAPPSPAEEFPVEEEIVKEASAEEEAEVEAVKEEEPEQE 400
              ::|..:|:.||.               |||    |::..:|......|...:.::..:....
Yeast   202 ATNKDSNKALPKRR---------------PSP----PLQSSLVGSGQLHENENLSSISIDSRHS- 246

  Fly   401 AVQEPEPEPVVEPEAEVQPEPVQQEEEKAESAEAKEEEKPAPVEEAEAEEESVQPEAAPK----- 460
              ..|:...|:...::..   :.|...:....|::.....:......:.:.|..|...|.
Yeast   247 --LNPDTSDVISNRSQTS---LSQTINQLSLCESEPSIASSNTTTTTSNQGSGLPNLVPNYSSDM 306

  Fly   461 -------------------------EPEAVQEEAQEDEPQ-----------TDGAQDAADDDDDT 489
                                     |.:|..||..:.|.|           |..:.:|.:|...:
Yeast   307 RKKKLVNKFKRKVFGSKPKHLSSQYEMDASSEELGQHEQQPSMRFKTTLRKTSVSTNAENDHASS 371

  Fly   490 KPEDELLWEGHIPENRRSRQHITELLQLDEEFNAREKATDNVAEIILRD-IKRIYENAVKPL--- 550
            ..|..|.:: :.|.|  ....:.:....|.|.:..:.|.....:   || |||...|:....
Yeast   372 LHEGNLRYK-YNPSN--DTYDVYDDTDSDSESDQNQDALTKPRK---RDRIKRKIRNSANKTAHH 430

  Fly   551 ETLYKYRDLSNRHFSDPEIFSKPLILFMGPWSGGKSSILNYLTDNE-------YTPNSLRTGAEP 608
            ..:::.||   |.|::.:           ||.  ..:.:.::||||       :..|..|
Yeast   431 RPIHRTRD---RKFNEDK-----------PWK--SHTDITFVTDNERKRYESMWVSNRHR----- 474

  Fly   609 SPAYFNILMW-----GNETEV----------------------LDGTQLAADYTFAGLQKFGQGL 646
               :.|:|.|     |:...:                      |..:.||..||....:|.|.
Yeast   475 ---HLNLLSWWPSITGDSGAINTLPEDGLILGIIVRDIWKRSNLPNSLLAEIYTKVDTRKDGT-- 534

  Fly   647 EERLRGLKMKSKILEKVNIVEIPGILEVRKQVSRVFPFNDACQW-FIDR-ADIIFLVYDPAKLDV 709
                  |..||.|   |.:..:...|..||..:.|    :.|.| .:|| |....:.....|...
Yeast   535 ------LDRKSFI---VGMWLVDQCLYGRKLPNVV----EQCVWDSVDRYASTTVVPVSTLKAMA 586

  Fly   710 GPETEAILDQLKGREYQTRIIL 731
            ..:.:.:.:::|..:.:.|::|
Yeast   587 KQKRKQMKEEIKNIKKENRVVL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9297	NP_788674.1	MSCRAMM_ClfA	<93..367	CDD:468110	26/160 (16%)
		TSP3 repeat_long	167..205	CDD:275366
		EHD_N	539..570	CDD:465295	8/33 (24%)
		EHD	574..813	CDD:206740	37/194 (19%)
IRS4	NP_012944.3	EH	<498..570	CDD:197477	18/86 (21%)